Relationship between Vitamin A and Bone Disease in Chronic Renal Failure

Rylance, Paul; Brown, Ivor John Carnegie; Howells, David W.; Nisbet, J A; Stone, Andrew; Eastwood, J. B.

doi:10.1159/000183133

Cited by 6 publications

(2 citation statements)

References 16 publications

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“…A positive correlation between serum VA and total serum Ca has been described [4,5], although it has not been generally confirmed [9]. Our results show that higher levels of VA are accompanied by a significantly elevated serum CA and lower serum P and PTH (ta ble II).…”

Section: Other Parameterscontrasting

confidence: 47%

Implications of Hypervitaminosis A on the Calcium-Phosphate Metabolism and on Blood Lipids in Hemodialysis

Praga¹,

Rubio

Morales³

et al. 1987

Am J Nephrol

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Serum levels of vitamin A (VA) were measured in 71 hemodialysis (HD) patients and in 30 normal controls. 65 of the 71 patients were taking multivitamin preparations (MP) containing VA. The HD patients had significantly greater values: 7.81 ± 2.86 μmol/l (224 ± 82 μg/dl) versus 3.97 ± 0.97 μmol/l (114 ± 28 μg/dl; p < 0.0005); those taking MP with large doses of VA showed the highest levels. Patients were divided as having normal (group I, n = 21) or elevated (group II, n ≈ 50) serum levels of VA. Patients of group II had higher levels of serum calcium (Ca) and lower of serum phosphate (P) and PTH than those of group I. Four months after the withdrawal of oral VA, the serum levels of VA and Ca fell significantly in group II, while the serum P increased. On the contrary, in group I serum levels of VA, Ca and P remained unchanged. Serum triglycerides (TG) were significantly higher in group II but did not change after the withdrawal of VA. No differences between both groups of patients were observed for age, time on HD, residual diuresis, residual renal function, serum levels of cholesterol (CL) or anemia. A retrospective study of 18 hepatic biopsies of HD patients disclosed hypeφlasia of Ito cells (VA-storaging cells) in 7 of them. These 7 biopsies belonged to patients who had taken large amounts of oral VA. Our data indicate that prolonged VA intake in HD patients is followed by an increase of serum CA, a decrease of serum P and PTH and a hepatic accumulation of VA. Since we observed a correlation between oral intake of VA and serum levels of VA, it is necessary to know the VA content of MP administered to HD patients.

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Section: Other Parameterscontrasting

confidence: 47%

Implications of Hypervitaminosis A on the Calcium-Phosphate Metabolism and on Blood Lipids in Hemodialysis

Praga¹,

Rubio

Morales³

et al. 1987

Am J Nephrol

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show abstract

“…Hence, dysfunction of glomerular filtration may lead to disordered retinol metabolism. Patients with chronic renal failure and patients on long term hemodialysis have been reported to have elevated plasma levels of both retinol and RBP [3][4][5][6], In some of these patients, blood and liver levels o f retinol were sufficiently high as to cause concern. Also, the skin of some uremic patients is reported to have high retinol levels and in these patients symptoms such as pruritis, xerosis and hair loss have been ascribed in part to hypervitaminosis A [5], Given the susceptibility o f long-term surviving kidney transplant recipients (KTxR) to progressive impairment o f kidney function, we were interested to study the reti noid status of these patients.…”

mentioning

confidence: 99%