Relationship between vitamin D and lung function, physical performance and balance on patients with stage I-III chronic obstructive pulmonary disease

Yumrutepe, Tuncay; Aytemur, Zeynep Ayfer; Baysal, Özlem; Taşkapan, Hülya; Taskapan, Cagatay; Hacievlıyagıl, Süleyman Savaş

doi:10.1590/1806-9282.61.02.132

Cited by 26 publications

(21 citation statements)

References 23 publications

(30 reference statements)

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“…The current study has shown that serum 25(OH)D concentration is a positive predictor of muscle strength (as measured by grip strength) at both the end of winter and the end of summer, and this association was stronger at the end of summer, when vitamin D status was higher. Indeed, in the current study, muscle strength was also ~40% higher in patients who reached vitamin D sufficiency at the end of summer compared to those who remained insufficient/deficient, confirming previous observations by others 28. Furthermore, those patients who reached vitamin D sufficiency at the end of summer were also more likely to be nonhousebound patients, reflecting the major source of vitamin D being sun exposure in this cohort.…”

Section: Discussionsupporting

confidence: 91%

“…Nonetheless, the majority of studies investigating the potential benefit of optimal vitamin D in COPD patients have focused on respiratory outcomes, with a dearth of studies considering its impact on the maintenance of muscle mass and function. One recent study reported that vitamin D deficient COPD patients had significantly lower handgrip strength and knee flexor muscle strength compared to vitamin D sufficient patients,28 whereas other studies have produced variable results 29–32…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D status is associated with muscle strength and quality of life in patients with COPD: a seasonal prospective observation study

Carson¹,

Pourshahidi²,

Madigan³

et al. 2018

COPD

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BackgroundOwing to hospitalization, reduced functional capacity and consequently, less sunlight exposure, suboptimal vitamin D status (25-hydroxyvitamin D [25(OH)D]⩽50 nmol/L) is prevalent among COPD patients.ObjectiveThis study aimed to investigate seasonal changes in vitamin D status and any associated changes in fat-free mass (FFM), muscle strength and quality of life (QoL) in COPD patients.Patients and methodsCOPD patients living in Northern Ireland (n=51) completed study visits at the end of winter (March/April) and at the end of summer (September/October), corresponding to the nadir and peak of vitamin D status, respectively. At both time points, serum concentration of 25(OH)D was quantified by liquid chromatography-tandem mass spectrometry, FFM (kg) was measured using bioelectrical impedance and muscle strength (kg) was measured using handgrip dynamometry. QoL was assessed using the validated St George’s Respiratory Questionnaire.ResultsMean±SD 25(OH)D concentration was significantly higher at the end of summer compared to the end of winter (52.5±30.5 nmol/L vs 33.7±28.4 nmol/L, P<0.001); and house- bound patients had significantly lower 25(OH)D concentration compared to nonhousebound patients at the end of summer (42.9±4.2 vs 57.2±9.9 nmol/L; P⩽0.001). Muscle strength (at both time points) and QoL (end of summer only) were positively predicted by 25(OH)D concentration, independent of age, sex and smoking status.ConclusionThis study highlights the need for health policies to include a recommendation for year-round vitamin D supplementation in housebound COPD patients, and wintertime supplementation in nonhousebound patients, to maintain optimal 25(OH)D concentrations to protect musculoskeletal health. Furthermore, an optimal vitamin D status may have potential benefits for QoL in these patients.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Vitamin D status is associated with muscle strength and quality of life in patients with COPD: a seasonal prospective observation study

Carson¹,

Pourshahidi²,

Madigan³

et al. 2018

COPD

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“…The 21 articles were published from 2010 to 2015 covering 4,818 COPD patients and 7,175 controls. For vitamin D levels and COPD, 13 articles18,20,22,23,27–29,32–35,37,38 were recruited. For vitamin D deficiency and COPD, 12 articles18–20,22,25,27,28,32,34,35,37,38 were included.…”

Section: Resultsmentioning

confidence: 99%

“…Thirteen studies18,20,22,23,27–29,32–35,37,38 reported the levels of serum vitamin D in 1,981 COPD patients and 1,283 control subjects. The pooled effect sizes showed that the serum vitamin D levels in COPD patients were lower than the levels in control subjects (SMD: −0.69, 95% CI: −1.00, −0.38, P <0.001; Figure 2), with significant heterogeneity among these studies ( I 2 =94.0%, P <0.001).…”

Section: Resultsmentioning

confidence: 99%

The association between vitamin D and COPD risk, severity, and exacerbation: an updated systematic review and meta-analysis

Zhu

Wang

et al. 2016

COPD

106

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BackgroundIn recent years, the pleiotropic roles of vitamin D have been highlighted in various diseases. However, the association between serum vitamin D and COPD is not well studied. This updated systematic review and meta-analysis aimed to assess the relationship between vitamin D and the risk, severity, and exacerbation of COPD.MethodsA systematic literature search was conducted in PubMed, Medline, EMBASE, Chinese National Knowledge Infrastructure, Wanfang, and Weipu databases. The pooled risk estimates were standardized mean difference (SMD) with 95% confidence interval (CI) for vitamin D levels and odds ratio (OR) with 95% CI for vitamin D deficiency. Meta-regression and subgroup analyses were performed on latitude, body mass index, and assay method.ResultsA total of 21 studies, including 4,818 COPD patients and 7,175 controls, were included. Meta-analysis showed that lower serum vitamin D levels were found in COPD patients than in controls (SMD: −0.69, 95% CI: −1.00, −0.38, P<0.001), especially in severe COPD (SMD: −0.87, 95% CI: −1.51, −0.22, P=0.001) and COPD exacerbation (SMD: −0.43, 95% CI: −0.70, −0.15, P=0.002). Vitamin D deficiency was associated with increased risk of COPD (OR: 1.77, 95% CI: 1.18, 2.64, P=0.006) and with COPD severity (OR: 2.83, 95% CI: 2.00, 4.00, P<0.001) but not with COPD exacerbation (OR: 1.17, 95% CI: 0.86, 1.59, P=0.326). Assay methods had significant influence on the heterogeneity of vitamin D deficiency and COPD risk.ConclusionSerum vitamin D levels were inversely associated with COPD risk, severity, and exacerbation. Vitamin D deficiency is associated with increased risk of COPD and severe COPD but not with COPD exacerbation. It is worth considering assay methods in the heterogeneity sources analysis of association between vitamin D deficiency and COPD.

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“…While the 1-min STS test is increasingly used in studies of COPD patients [8,[10][11][12][13][14][15][16], its learning effect, reliability, responsiveness to change and minimal important difference (MID) have not yet been established in this patient population. Furthermore, little is known about the physiological response to the 1-min STS test in terms of the cardiorespiratory stress elicited.…”

Section: Introductionmentioning

confidence: 99%

A multicentre validation of the 1-min sit-to-stand test in patients with COPD

et al. 2017

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Our aim was to comprehensively validate the 1-min sit-to-stand (STS) test in chronic obstructive pulmonary disease (COPD) patients and explore the physiological response to the test.We used data from two longitudinal studies of COPD patients who completed inpatient pulmonary rehabilitation programmes. We collected 1-min STS test, 6-min walk test (6MWT), health-related quality of life, dyspnoea and exercise cardiorespiratory data at admission and discharge. We assessed the learning effect, test-retest reliability, construct validity, responsiveness and minimal important difference of the 1-min STS test.In both studies (n=52 and n=203) the 1-min STS test was strongly correlated with the 6MWT at admission (r=0.59 and 0.64, respectively) and discharge (r=0.67 and 0.68, respectively). Intraclass correlation coefficients (95% CI) between 1-min STS tests were 0.93 (0.83-0.97) for learning effect and 0.99 (0.97-1.00) for reliability. Standardised response means (95% CI) were 0.87 (0.58-1.16) and 0.91 (0.78-1.07). The estimated minimal important difference was three repetitions. End-exercise oxygen consumption, carbon dioxide output, ventilation, breathing frequency and heart rate were similar in the 1-min STS test and 6MWT.The 1-min STS test is a reliable, valid and responsive test for measuring functional exercise capacity in COPD patients and elicited a physiological response comparable to that of the 6MWT.

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Relationship between vitamin D and lung function, physical performance and balance on patients with stage I-III chronic obstructive pulmonary disease

Cited by 26 publications

References 23 publications

Vitamin D status is associated with muscle strength and quality of life in patients with COPD: a seasonal prospective observation study

Vitamin D status is associated with muscle strength and quality of life in patients with COPD: a seasonal prospective observation study

The association between vitamin D and COPD risk, severity, and exacerbation: an updated systematic review and meta-analysis

A multicentre validation of the 1-min sit-to-stand test in patients with COPD

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