Relationship between vitamin D-binding protein polymorphisms and blood vitamin D level in Korean patients with COPD

Park, Youngmok; Kim, Young Sam; Kang, Young Ae; Shin, Ju Hye; Oh, Yeon Mok; Seo, Joon Beom; Jung, Ji Ye; Lee, Sang Do

doi:10.2147/copd.s96985

Cited by 10 publications

(8 citation statements)

References 34 publications

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“…The association between lung function and GRS was not affected by 25(OH)D levels, and the association between lung function and 25(OH)D levels were not affected by GRS. In line with our results, in a cohort of Korean COPD patients primarily consisting of males (97.7%), low 25(OH)D was associated with FEV1/FVC [ 43 ] regardless of rs4081 or rs7041 genotypes (both located on GC ). Coronary lesions [ 53 ] and tuberculosis [ 54 ] have also been associated with 25(OH)D levels, but not with vitamin D relevant SNPs.…”

Section: Discussionsupporting

confidence: 87%

“…One small study in Korean COPD patients, predominantly consisting of men, found that genotype was associated with vitamin D deficiency (25(OH)D < 20 ng/mL), but vitamin D deficiency was associated with lower FEV1/FVC, regardless of GC genotype. The genotypes of specific variants of SNPs rs4588 and rs7041 [ 43 ] were assessed in this study. These two SNPs are in strong linkage disequilibrium with rs2282679 assessed in our study and the results are similar to our results observed in men.…”

Section: Discussionmentioning

confidence: 99%

“…Coronary lesions [ 53 ] and tuberculosis [ 54 ] have also been associated with 25(OH)D levels, but not with vitamin D relevant SNPs. On the other hand, in Korean men, emphysema was associated with the genotypes of rs4081 and rs7041, but not with vitamin D deficiency [ 43 ]. Polymorphisms of rs4081 and rs7041 result in changes in amino acids and the function of the vitamin D-binding protein [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

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Genetic Association between Serum 25-Hydroxyvitamin D Levels and Lung Function in Korean Men and Women: Data from KNHANES 2011–2012

Park

Kwak

et al. 2018

Nutrients

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The association between single-nucleotide polymorphisms (SNPs) in the vitamin D metabolic pathway and lung function is unknown. We examined the association between five SNPs on DHCR7, GC, CYP2R1, and CYP24A1 along with serum 25-hydroxyvitamin D (25(OH)D) levels and lung function in older Korean men (n = 758) and women (n = 837). Lung function was determined by forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) from the data in the Korea Nutrition and Health Examination Survey 2011–2012. Genetic risk score (GRS) was calculated by the number of 25(OH)D-decreasing alleles of the five SNPs. Our results showed that increases in GRS were associated with reduced 25(OH)D levels (p < 0.05 for both sexes). In the entire population, FVC and FEV1 were associated with both GRS and 25(OH)D levels. In women, FVC and FEV1 were negatively associated with GRS (β-coefficient (95% CI): −0.022 (−0.039, −0.005) and −0.020 (−0.035, −0.005), respectively; both p < 0.05), but not with 25(OH)D. However, in men, FVC and FEV1 were positively associated with 25(OH)D (β-coefficient (95% CI): 0.008 (0.001, 0.016) and 0.008 (0.002, 0.015), respectively; both p < 0.05), but not with GRS. In conclusion, lung function was associated with genetic variation in Korean women and with 25(OH)D in Korean men.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Genetic Association between Serum 25-Hydroxyvitamin D Levels and Lung Function in Korean Men and Women: Data from KNHANES 2011–2012

Park

Kwak

et al. 2018

Nutrients

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“…Also, serum levels of 25-OHD show seasonal variation. The prevalence of vitamin D deficiency is high during the winter months (28, 29). One limitation in the meta-analysis study showed that only one study contained African ethnicity (26), so this is considered the first study in Egypt.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Vitamin D, Vitamin D Binding Protein Gene Polymorphism with Oxidant – Antioxidant Profiles in Chronic Obstructive Pulmonary Disease

Al-Azzawi¹,

Ghoneim²,

Elmadbouh³

2017

Journal of Medical Biochemistry

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SummaryBackground: The aim was to evaluate the association of plasma 25-hydroxyvitamin D (25-OHD) and vitamin D binding protein (VDBP or Gc-globin) gene polymorphism with oxidant-antioxidant profiles in patients with chronic obstructive pulmonary disease (COPD), and their role as biomarker risk factors in susceptibility and severity of COPD. Methods: Eighty patients diagnosed with COPD (mild, moderate and severe according to lung function tests; FEV 1%) and 80 healthy controls were included in the study. Serum nitric oxide (NO) and lipid peroxide (LP), plasma reduced glutathione (RGSH), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) activity, 25-OHD and VDBP polymorphism were analyzed in all subjects. Results: COPD patients had significantly decreased serum NO, plasma SOD, RGSH, GSH-Px, CAT and 25-OHD versus controls, but had significantly increased serum LP. In COPD patients, 25-OHD levels were significantly lower (41.49± 13.65 ng/mL) versus controls, but more lower in severe COPD patients (30.54±9.09 ng/mL; sensitivity 79.2%; specificity 73.2%, p<0.001) versus mild and moderate COPD. VDBP genotypes frequencies were Gc1S-1S=23.8%, Gc1F-

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“…VDBP is found in human cerebrospinal fluid [8] and is a serum protein encoded by the GC gene – the main carrier protein responsible for the transfer of calcitriol to target neurons [2]; however, little is known about the role of VDBP in the central nervous system [9]. Two common functional single nucleotide polymorphisms (SNPs) are present in exon 11 of the GC gene, and they result in nucleotide substitutions in codon 416 (GAT to GAG; Asp to Glu; rs7041) and codon 420 (AAG to ACG; Thr to Lys; rs4588) [10].…”

Section: Introductionmentioning

confidence: 99%

A High-Protein/Low-Fat Diet May Interact with Vitamin D-Binding Protein Gene Variants to Moderate the Risk of Depression in Apparently Healthy Adults

et al. 2018

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Background: Recent studies have shown that depression is inversely correlated with high protein and low fat intake and positively correlated with vitamin D-binding protein (VDBP). Therefore, the aim of this study was to examine the interaction between protein/fat dietary patterns and VDBP genotypes with regard to the risk of depression in apparently healthy adults who have not been diagnosed with any chronic disease. Methods: In this study, 265 individuals (126 males and 139 females) aged 18–55 years were recruited from the communities of central and west Tehran based on convenience sampling. Body composition was measured with a body composition analyzer and depression symptoms were categorized as normal, moderate depression, or severe depression using the Depression Anxiety Stress Scales 21 (DASS-21) questionnaire. Dietary patterns were determined by a semiquantitative food frequency questionnaire to assess typical food intake during the 12-month period. Blood samples were collected from and biochemical measurements performed on all participants. An analysis of two polymorphisms (rs7041 and rs4588) in the GC gene, which encodes VDBP, was performed by polymerase chain reaction-restriction fragment length polymorphism. Results: A statistically significant association was found between depression and diet (p = 0.03) after having categorized the participants into three groups: a high-protein/low-fat (HP/LF) group, a moderate-protein/moderate-fat (MP/MF) group, and a low-protein/high-fat (LP/HF) group. Moreover, the findings demonstrated that depression was related to both the rs7041 and the rs4588 polymorphism (p = 0.05 and p = 0.02, respectively). We next used multinomial logistic modeling to investigate the risk of depression. A significant interaction was observed between HP/LF diet and the rs7041 polymorphism in the moderate- and severe-depression groups (β = –0.30, p = 0.05, and β = –0.48, p = 0.01, respectively). Conclusion: This study showed that an HP/LF diet interacts with the rs7041 polymorphism, with T allele carriers having a greater prevalence of moderate and severe depression.

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Relationship between vitamin D-binding protein polymorphisms and blood vitamin D level in Korean patients with COPD

Cited by 10 publications

References 34 publications

Genetic Association between Serum 25-Hydroxyvitamin D Levels and Lung Function in Korean Men and Women: Data from KNHANES 2011–2012

Genetic Association between Serum 25-Hydroxyvitamin D Levels and Lung Function in Korean Men and Women: Data from KNHANES 2011–2012

Evaluation of Vitamin D, Vitamin D Binding Protein Gene Polymorphism with Oxidant – Antioxidant Profiles in Chronic Obstructive Pulmonary Disease

A High-Protein/Low-Fat Diet May Interact with Vitamin D-Binding Protein Gene Variants to Moderate the Risk of Depression in Apparently Healthy Adults

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