Relationship Between Vitamin D Level and Platelet Parameters in Children With Viral Respiratory Infections

Feketea, Gavriela; Vlacha, Vasiliki; Pop, Raluca Maria; Bocşan, Ioana Corina; Stanciu, Luminita A.; Zdrenghea, Dumitru

doi:10.3389/fped.2022.824959

Cited by 5 publications

(5 citation statements)

References 54 publications

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“…Also, the median vit D level was higher in the children with a single episode of wheezing than in the control group. This could be explained by the fact that the control group consisted of older children, and in winter the serum level of vit D is reported to be lower in older children [35], as confirmed by the authors in previous studies [36,37]. In our study, significantly lower levels of vit D were found in children with recurrent wheezing than in either of those with a single episode, or in the control group, only at baseline evaluation.…”

Section: Discussionsupporting

confidence: 89%

Vitamin D Level and Immune Modulation in Children with Recurrent Wheezing

Feketea,

Vassilopoulou,

Andreescu

et al. 2024

Children

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Introduction and aim: A direct causal relationship between vitamin D (vit D) deficiency and recurrent wheezing has not been proven. The present study investigated the role of vit D in enhancing the risk of asthma or recurrent wheezing by modifying the intensity of the inflammatory process. Material and method: Forty children with wheezing presenting at the emergency service and sixteen healthy control subjects were included in the study. Children with wheezing were either in the first episode (20) or with recurrent wheezing (20). Children with chronic diseases, and other conditions that present with acute wheezing or that might influence the vit D level, were excluded. Blood samples were taken at presentation and 3–6 months later, to evaluate the serum levels of total IgE, vit D, IL-10 and IL-31. Statistical analysis was performed using the SPSS 25 program, with a significance level of p < 0.05. Results and conclusion. The vit D level was lower in patients with recurrent wheezing compared with those with a single episode and with the control group, and this increased with time. IL-10 was significantly higher in children with wheezing than in the control group, with the highest values in those with an acute episode of wheezing. IL-31 was higher in children with recurrent wheezing than in those with a first episode only at the initial point, while at the final time point it was lower. Low levels of vit D appear to be detected more frequently in recurrent wheezing than in simple wheezing. Immune modulation, as measured by Th2 status reflected by IL-10 and IL-31 levels, appears to depend on the wheezing phenotype and on the general health status.

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Section: Discussionsupporting

confidence: 89%

Vitamin D Level and Immune Modulation in Children with Recurrent Wheezing

Feketea,

Vassilopoulou,

Andreescu

et al. 2024

Children

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“…To analyze platelet function, first, we tested some specific platelet markers from GBC and derivatives (as described in the Methods). It has been shown that platelets do change in size and volume when stimulated [ 24 , 25 ]. We found no significant changes in MPV, PDW, P-LCR, or other platelet markers between the study groups.…”

Section: Discussionmentioning

confidence: 99%

Platelet-Derived Biomarkers: Potential Role in Early Pediatric Serious Bacterial Infection and Sepsis Diagnostics

Pociūtė

Farook

Dagys

et al. 2022

JCM

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Fever is the most common complaint of children who are attending a pediatric emergency department (PED). Most of the fever cases are of viral origin; however, the most common markers, such as leucocyte, neutrophil count, or C-reactive protein, are not sensitive or specific enough to distinguish the etiology of fever, especially if children present at the early phase of infection. Currently, platelets have been attributed a role as important sentinels in viral and bacterial infection pathogenesis. Thus, our aim was to analyze different platelet indices, such as PNLR (platelet-to-neutrophil/lymphocyte ratio), PNR (platelet-to-neutrophil ratio) as well as specific secreted proteins, such as sP-selectin, CXCL4, CXCL7, and serotonin. We included 68 children who were referred to PED with the early onset of fever (<12h). All children with comorbidities, older than five years, and psychiatric diseases, who refused to participate were excluded. All the participants were divided into viral, bacterial, or serious bacterial infection (SBI) groups. All the children underwent blood sampling, and an additional sample was collected for protein analysis. Our analysis revealed statistically significant differences between leucocyte, neutrophil, and CRP levels between SBI and other groups. However, leucocyte and neutrophil counts were within the age norms. A higher PNLR value was observed in a bacterial group, PNR-in viral. As we tested CXCL7 and sP-selectin, alone and together those markers were statistically significant to discriminate SBI and sepsis from other causes of infection. Together with tachypnoe and SpO2 < 94%, it improved the prediction value of sepsis as well as SBI. CXCL4 and serotonin did not differ between the groups. Concluding, CXCL7 and sP-selectin showed promising results in early SBI and sepsis diagnosis.

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“…CXCL7 and sP-selectin, alone and combined, are statistically significant to discriminate sepsis and bacterial infections from other diseases [17]. In pediatric patients in whom an acute infectious event is suspected, CXCL4 and serotonin levels are not indicative in discriminating the etiology of the event in progress; CXCL4 has a role during the viral response, and its elevation in the blood stream is not significant in patients with sepsis or bacterial infections [18]. However, the values are not yet standardized in the pediatric population, and more studies are necessary to confirm normal values in healthy children and in different clinical conditions, i.e., chronic inflammation, trauma, and acute infection [19].…”

Section: Platelet Indicesmentioning

confidence: 99%

Biomarkers for Serious Bacterial Infections in Febrile Children

Bernardi,

Bossù,

Dal Canto

et al. 2024

Biomolecules

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Febrile infections in children are a common cause of presentation to the emergency department (ED). While viral infections are usually self-limiting, sometimes bacterial illnesses may lead to sepsis and severe complications. Inflammatory biomarkers such as C reactive protein (CRP) and procalcitonin are usually the first blood exams performed in the ED to differentiate bacterial and viral infections; nowadays, a better understanding of immunochemical pathways has led to the discovery of new and more specific biomarkers that could play a role in the emergency setting. The aim of this narrative review is to provide the most recent evidence on biomarkers and predictor models, combining them for serious bacterial infection (SBI) diagnosis in febrile children. Literature analysis shows that inflammatory response is a complex mechanism in which many biochemical and immunological factors contribute to the host response in SBI. CRP and procalcitonin still represent the most used biomarkers in the pediatric ED for the diagnosis of SBI. Their sensibility and sensitivity increase when combined, and for this reason, it is reasonable to take them both into consideration in the evaluation of febrile children. The potential of machine learning tools, which represent a real novelty in medical practice, in conjunction with routine clinical and biological information, may improve the accuracy of diagnosis and target therapeutic options in SBI. However, studies on this matter are not yet validated in younger populations, making their relevance in pediatric precision medicine still uncertain. More data from further research are needed to improve clinical practice and decision making using these new technologies.

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Relationship Between Vitamin D Level and Platelet Parameters in Children With Viral Respiratory Infections

Cited by 5 publications

References 54 publications

Vitamin D Level and Immune Modulation in Children with Recurrent Wheezing

Vitamin D Level and Immune Modulation in Children with Recurrent Wheezing

Platelet-Derived Biomarkers: Potential Role in Early Pediatric Serious Bacterial Infection and Sepsis Diagnostics

Biomarkers for Serious Bacterial Infections in Febrile Children

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