This paper proposes a reliable method for estimation of the movement and spread of lift-generated vortex wakes as a function of time to better enable aircraft arriving at airports to avoid the hazards associated with the wakes of preceding aircraft. Operations on closely-spaced parallel runways illustrate how the method may be applied. An overview presents the aerodynamic mechanisms that cause the hazardous parts of lift-generated wakes to spread as a function of time. A computational method developed for determination of the spread of vortex wakes as a function of time is then applied to operations of aircraft as they approach closely-spaced parallel runways. The results suggest guidelines for efficiently and effectively avoiding the vortex wakes of preceding aircraft. Because the theoretical tools developed and the measurements of the components of the time-averaged wind and its gust magnitudes contain uncertainties, flight tests are recommended to confirm and to refine the guidelines presented, and to verify the techniques used to measure the atmospheric parameters that control wake intrusion.