Relationship between Weight, Body Mass Index, and Bone Mineral Density in Men Referred for Dual-Energy X-Ray Absorptiometry Scan in Isfahan, Iran

Abstract

Objective. Although several studies have investigated the association between body mass index (BMI) and bone mineral density (BMD), the results are inconsistent. The aim of this study was to further investigate the relation between BMI, weight and BMD in an Iranian men population. Methods. A total of 230 men 50-79 years old were examined. All men underwent a standard BMD scans of hip (total hip, femoral neck, trochanter, and femoral shaft) and lumbar vertebrae (L2-L4) using a Dual-Energy X-ray Absorptiometry (DXA) scan and examination of body size. Participants were categorised in two BMI group: normal weight <25.0 kg/m2 and overweight and obese, BMI ≥ 25 kg/m2. Results. Compared to men with BMI ≥ 25, the age-adjusted odds ratio of osteopenia was 2.2 (95% CI 0.85, 5.93) and for osteoporosis was 4.4 (1.51, 12.87) for men with BMI < 25. It was noted that BMI and weight was associated with a high BMD, compatible with a diagnosis of osteoporosis. Conclusions. These data indicate that both BMI and weight are associated with BMD of hip and vertebrae and overweight and obesity decreased the risk for osteoporosis. The results of this study highlight the need for osteoporosis prevention strategies in elderly men as well as postmenopausal women.

Serum Osteocalcin as a Diagnostic Biomarker for Primary Osteoporosis in Women

“…Significant positive correlation of BMI and BMD has been reported in literature but our study failed to confirm this [11][12][13][14][15]. The reason might be because of non-significant difference between the weight of controls and cases.…”

Analysis of Bone Mineral Density according to Hemoglobin in University Students

“…In addition to DEXA, osteoporosis examination can be done with BMI [16]. Overweight and obesity have been considered protective to bone health, while higher BMI levels to be associated with higher BMD score [17][18][19][20]. In this study, the height and weight were positively correlated with BMD and the same result.…”

Body weight, BMI, and stature have a protective effect on bone mineral density in women with postmenopausal vertebral osteoporosis, whereas greater age at menarche and years after menopause have a negative effect

“…For simple regressions using body weight and BMI as independent variables, the correlation coefficients were positive, indicating that an increase in weight, and BMI, leads to an increase in spinal BMD. This finding is consistent with other studies that have shown a positive association between body weight and BMD in women after menopause [22], between BMI and BMD, and between weight and BMD in men [16], and between BMI and BMD regardless of age, sex, or race [23].…”

“…Anthropometric and reproductive variables represent risk factors of greater importance for osteoporosis than the risk factors related to life style [14]. A low body mass index (BMI) is a risk factor for bone loss [15], and being overweight has a protective effect against osteoporosis [16]. The outcomes of another study showed that women with postmenopausal osteoporosis do not have a higher BMI than the values recommended by the National Institutes of Health [17].…”