Relationship between weight loss in obese knee osteoarthritis patients and serum biomarkers of cartilage breakdown: secondary analyses of a randomised trial

Bartels, Else Marie; Henrotin, Yves; Bliddal, Henning; Centonze, Prescilia; Henriksen, Marius

doi:10.1016/j.joca.2017.06.009

Cited by 11 publications

(5 citation statements)

References 24 publications

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“…The decrease in these markers over the course of the study and two systemic markers of inflammation, MMP-derived inflammation (CRPM) and interleukin-6 (IL-6), were strongly associated with weight loss indicating that overweight and obese adults with KOA who lose weight experienced reduced inflammation at a systemic as well as tissue level 14 ( Table I). In contrast, among overweight KOA patients who followed a 16-week weight loss intervention and 52-week weight maintenance, the clinical improvement after weight loss and weight maintenance was not associated with change in serum markers of Coll2-1 and fibulin3-2 15 (Table I). Type II collagen is a major structural protein of the cartilage and together with other collagen types and non-collagenous proteins, such as COMP, provides a tensile meshwork for cartilage 2 .…”

Section: Association With Clinical Scores and Changesmentioning

confidence: 90%

Osteoarthritis year in review 2018: biomarkers (biochemical markers)

Hosnijeh

Bierma-Zeinstra

Bay‐Jensen

2019

Osteoarthritis and Cartilage

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The aim of this narrative review is to summarize important findings from biochemical marker studies relevant to osteoarthritis (OA) in the context of new discoveries and clinical and scientific need. Design: We conducted a systematic search of electronic medical databases (Embase, Medline, Web of Science, Cochrane central) between 01-03-2017 and 31-03-2018. The search was restricted to human studies, English language and full text available publications while reviews were excluded. Only papers describing protein based biomarkers measured in human body fluids (blood, urine and synovial fluid (SF)) were included. Of the 992 papers, 86 were reviewed here, with inclusion primarily based on relevance to OA biochemical markers. Results: This review highlights a selection of studies based on their quality and perceived importance to the field mainly including those that 1 evaluate prognostic value of biomarkers for OA progression (i.e., biomarkers reflecting change in composition of joint tissues and biomarkers of inflammation) 2 , help in assessment of intervention efficacy, and 3 are innovative and uncover new candidate biomarkers, or use new approaches in biomarker discovery. Conclusions: Key findings and implications for possible clinical utility of biochemical markers are summarized and discussed. Given the paucity of robust biomarkers within the field, and the heterogeneity of the condition, enormous works are needed for development and validation of novel and clinically applicable biomarkers to reduce the impact of this highly prevalent and debilitating condition.

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Section: Association With Clinical Scores and Changesmentioning

confidence: 90%

Osteoarthritis year in review 2018: biomarkers (biochemical markers)

Hosnijeh

Bierma-Zeinstra

Bay‐Jensen

2019

Osteoarthritis and Cartilage

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“…The current study examined the relationship of Pb-exposure with pain and discomfort in the musculoskeletal system and BTMs. As documented in the literature, cartilage break down 61 and lower cartilage thickness 62 are associated with knee osteoarthritis. The present study assessed the relationship between bone resorption markers and discomfort in the musculoskeletal system among workers.…”

Section: Discussionmentioning

confidence: 83%

Association between Musculoskeletal Pain and Bone Turnover Markers in Long-Term Pb-Exposed Workers

2021

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Background: On chronic exposure, Lead (Pb) deposits in the skeletal system, replaces calcium ions, and alters the normal physiological processes, which in turn, lead to stunting, delayed fracture healing, and high resorption of collagen molecules. The present study aimed to assess the association of musculoskeletal pain and discomfort with bone turnover markers (BTMs) among long-term Pb-exposed workers. Study design: A cross-sectional study. Methods: The study recruited 176 male Pb-exposed workers and 80 control subjects who were matched for age, gender, and socio-economic status. Blood lead levels (BLLs), bone growth markers, such as serum osteocalcin (OC), alkaline phosphatase (ALP), bone alkaline phosphatase (BAP), and bone resorption markers: serum pyridinoline (Pry), deoxypyridinoline (DPry), tartrate-resistant acid phosphatase-5b(TRACP-5b), and hydroxyproline in urine (HyP-U) of participants were investigated. Pain and discomfort in the musculoskeletal system were assessed using Nordic Musculoskeletal Questionnaire. Results: Pb-exposure was significantly associated with musculoskeletal discomfort of the lower back (P<0.001), upper back (P<0.001), and ankle/foot (P=0.011). Among bone formation markers, serum OC was significantly lower in musculoskeletal discomfort of elbows (P=0.033) and ankle/foot (P=0.042). Among bone resorption markers, serum DPry was significantly lower in musculoskeletal discomfort of the neck (P=0.049) and shoulders (P=0.023). HyP-U was significantly higher in musculoskeletal discomfort of shoulders (P=0.035) and lower back (P=0.036). Conclusion: As evidenced by the obtained results, Pb-exposure was associated with musculoskeletal discomfort of the lower back, upper back, and ankle/foot. Lower bone formation (serum OC) marker was noted with musculoskeletal discomfort of elbows and ankle/foot. Furthermore, bone resorption markers were associated with musculoskeletal discomfort of the neck, shoulders, and lower back. The findings of the present study suggested that long-term Pb-exposure and BTMs were associated with musculoskeletal discomfort.

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“…Four studies investigated longterm urinary CTX-II response, of which three showed decreased levels and one showed no difference. A large study by Bartels et al 23 investigated another marker of collagen degradation, coll2-1, in an exercise cohort preceded by a weight loss intervention. Here, coll2-1 did not change significantly.…”

Section: Resultsmentioning

confidence: 99%

The acute and long‐term impact of physical activity on biochemical markers and MRI measures in osteoarthritis—Perspectives for clinical osteoarthritis research

et al. 2020

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We aimed to investigate existing literature on the impact of physical activity and exercise (PA) on joint biochemical markers (BM) and magnetic resonance imaging (MRI) outcomes in osteoarthritis (OA), and on this basis propose directions for future research. Literature Review. Original papers were identified in PubMed, Embase, and Scopus and data on study populations, activity, biomarkers, imaging, and outcomes were extracted and reviewed. 24 papers, mainly on knee OA, were included. PA indicated acute increase in cartilage turnover in OA patients, as indicated by changes in markers of extra cellular matrix (ECM) turnover. Acute impact of PA on MRI outcomes in OA appears to constitute a gap in the literature, as only 1 study was identified. Long‐term effects of PA may be chondroprotective, judged from decreased serum BM. Studies of long‐term effects of PA on MRI measures showed various neutral, and both discrete positive and negative effects. Impact of PA on BM warrants further studies including information of potential coexisting inflammatory and structural changes on the joint level on MRI, in order to determine the significance of the BM findings. Development of a standardized method for clinical evaluation of BM dynamics following PA is warranted.

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Relationship between weight loss in obese knee osteoarthritis patients and serum biomarkers of cartilage breakdown: secondary analyses of a randomised trial

Abstract: The clinical improvement after a substantial weight loss and weight maintenance in KOA patients was not associated with decrease in markers of cartilage breakdown Coll2-1 or Fib3-2, even with indications of a slightly negative effect.

Cited by 11 publications

References 24 publications

Osteoarthritis year in review 2018: biomarkers (biochemical markers)

Osteoarthritis year in review 2018: biomarkers (biochemical markers)

Association between Musculoskeletal Pain and Bone Turnover Markers in Long-Term Pb-Exposed Workers

The acute and long‐term impact of physical activity on biochemical markers and MRI measures in osteoarthritis—Perspectives for clinical osteoarthritis research

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