Relationship between work rate and oxygen uptake in mitochondrial myopathy during ramp-incremental exercise

Gimenes, Ana Cristina; Neder, J. Alberto; Corso, Simone Dal; Nogueira, Cristiano Rabelo; Nápolis, Lara Maris; Mello, Marco Túlio de; Bulle, Acari; Nery, Luíz Eduardo

doi:10.1590/s0100-879x2011007500023

Cited by 10 publications

(3 citation statements)

References 38 publications

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“…Our patients also showed significantly lower maximum exercise capacity and peak

compared to controls. Several studies evaluating exercise tolerance in MM have demonstrated markedly low

peak ( 23 - 27 ), reflecting impaired muscle mitochondrial oxidative phosphorylation. The maximal exercise capacity of MM subjects has been shown to directly correlate with the degree of O 2 extraction in the impaired muscle, which enables the use of the systemic arterial to venous O 2 difference as a surrogate marker for mitochondrial oxidative capacity ( 3 , 4 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of L-carnitine on exercise performance in patients with mitochondrial myopathy

Gimenes

Bravo

Nápolis

et al. 2015

Braz J Med Biol Res

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Exercise intolerance due to impaired oxidative metabolism is a prominent symptom in patients with mitochondrial myopathy (MM), but it is still uncertain whether L-carnitine supplementation is beneficial for patients with MM. The aim of our study was to investigate the effects of L-carnitine on exercise performance in MM. Twelve MM subjects (mean age±SD=35.4±10.8 years) with chronic progressive external ophthalmoplegia (CPEO) were first compared to 10 healthy controls (mean age±SD=29±7.8 years) before they were randomly assigned to receive L-carnitine supplementation (3 g/daily) or placebo in a double-blind crossover design. Clinical status, body composition, respiratory function tests, peripheral muscle strength (isokinetic and isometric torque) and cardiopulmonary exercise tests (incremental to peak exercise and at 70% of maximal), constant work rate (CWR) exercise test, to the limit of tolerance [Tlim]) were assessed after 2 months of L-carnitine/placebo administration. Patients with MM presented with lower mean height, total body weight, fat-free mass, and peripheral muscle strength compared to controls in the pre-test evaluation. After L-carnitine supplementation, the patients with MM significantly improved their Tlim (14±1.9 vs 11±1.4 min) and oxygen consumption (V˙O2) at CWR exercise, both at isotime (1151±115 vs 1049±104 mL/min) and at Tlim (1223±114 vs 1060±108 mL/min). These results indicate that L-carnitine supplementation may improve aerobic capacity and exercise tolerance during high-intensity CWRs in MM patients with CPEO.

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“…Our patients also showed significantly lower maximum exercise capacity and peak

compared to controls. Several studies evaluating exercise tolerance in MM have demonstrated markedly low

Section: Discussionmentioning

confidence: 99%

Effect of L-carnitine on exercise performance in patients with mitochondrial myopathy

Gimenes

Bravo

Nápolis

et al. 2015

Braz J Med Biol Res

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“…The effects of exercise on patients with myocardial insufficiency was investigated in three different pathological conditions: Gimenes et al 11 determined the response characteristics and functional correlates of the dynamic relationship between peak O 2 consumption vs. power output during ramp-incremental…”

Section: Resultsmentioning

confidence: 99%

[ARTIGO RETRATADO] Exercício e suas interações com vários aspectos da vida do homem e dos animais

Gomes¹,

Rocha-e-Silva²

2012

Acta ortop. bras.

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To review recently published papers in the Brazilian Scientific press on the general subject of physical exercise. All articles published in 2010/2011 found through the keyword exercise were collected from 11 Brazilian Journals. They were hand filtered to exclude all but original research papers. They were grouped according to subject categories and subcategories. A brief summary of all included articles was produced, comparing similar articles between them. The most commonly found interactions refer to exercise vs. the cardiovascular system, metabolism and the locomotor system, in this order. The volume of scientific research in the field is high and of sufficient quality to justify highlighting.

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“…A shallow

Δ {\overset{V}{true}}_{O_{normal2}} / Δ WR

over the entire range of values and/or a shift from a linearly increasing profile to a shallower rate of change has been shown to be indicative of circulatory dysfunction [77–80] (Figure 4) and severe impairment in mitochondrial function [81]. The latter pattern of response has been found to enhance ECG sensitivity to detect myocardial ischemia [82–86], and some studies suggested that it might be useful to unravel early abnormalities in the coronary microcirculation [87, 88].…”

Section: Metabolic Responsesmentioning

confidence: 99%

Clinical Usefulness of Response Profiles to Rapidly Incremental Cardiopulmonary Exercise Testing

et al. 2013

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The advent of microprocessed “metabolic carts” and rapidly incremental protocols greatly expanded the clinical applications of cardiopulmonary exercise testing (CPET). The response normalcy to CPET is more commonly appreciated at discrete time points, for example, at the estimated lactate threshold and at peak exercise. Analysis of the response profiles of cardiopulmonary responses at submaximal exercise and recovery, however, might show abnormal physiologic functioning which would not be otherwise unraveled. Although this approach has long been advocated as a key element of the investigational strategy, it remains largely neglected in practice. The purpose of this paper, therefore, is to highlight the usefulness of selected submaximal metabolic, ventilatory, and cardiovascular variables in different clinical scenarios and patient populations. Special care is taken to physiologically justify their use to answer pertinent clinical questions and to the technical aspects that should be observed to improve responses' reproducibility and reliability. The most recent evidence in favor of (and against) these variables for diagnosis, impairment evaluation, and prognosis in systemic diseases is also critically discussed.

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Relationship between work rate and oxygen uptake in mitochondrial myopathy during ramp-incremental exercise

Cited by 10 publications

References 38 publications

Effect of L-carnitine on exercise performance in patients with mitochondrial myopathy

Effect of L-carnitine on exercise performance in patients with mitochondrial myopathy

[ARTIGO RETRATADO] Exercício e suas interações com vários aspectos da vida do homem e dos animais

Clinical Usefulness of Response Profiles to Rapidly Incremental Cardiopulmonary Exercise Testing

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