Relationship between zinc levels and anthropometric indices among school-aged female children with sickle cell anemia in enugu, Nigeria

Onukwuli, VO; Ikefuna, AN; Nwokocha, AR; Emodi, IJ; Eke, Christopher Bismarck

doi:10.4103/njcp.njcp_104_17

Cited by 8 publications

(5 citation statements)

References 2 publications

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“…[34] Additional studies similarly detected one or more growth de cits in adolescents but not in younger children [39][40][41][42][43][44]. In several Nigerian studies, SCD patients were found to be underweight or to have low BMI, but showed no difference in height compared to controls [37,42,[45][46][47][48]; while other Nigerian studies showed differences in both weight and height [33,35,36,47,49,50]. These variable ndings may have resulted from the fact that the studies were not powered to detect signi cant differences in height speci cally.…”

Section: Resultsmentioning

confidence: 99%

Nutritional perspectives on sickle cell disease in Africa: A systematic review

Nartey

Spector

Adu‐Afarwuah

et al. 2021

Preprint

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Background: Sickle cell disease (SCD), an inherited blood disorder, predominantly affects individuals in sub-Saharan Africa. Research linking its pathophysiology and nutritional status in African patients has not been previously described. This systematic review aimed to assess the landscape of studies in sub-Saharan Africa focused on nutritional aspects of SCD and highlight gaps in knowledge that could inform priority-setting for future research.Methods: The study was conducted using the Preferred Reporting items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. All original studies involving individuals with any phenotypic variant of SCD and at least one nutritional status outcome; and were conducted between January 1995 and November 2020 in Africa were included. ‘Nutritional status’ was defined by studies on dietary intake, measurements of growth/anthropometry, or nutritional biomarkers. Studies were included if they involved Databases used were Ovid Embase, Medline, Biosis and Web of Science. Results: The search returned 526 articles with 76 studies included in the final analyses. Most investigations (67%) were conducted in Nigeria. Studies were categorized into one of three main categories: descriptive studies of anthropometric characteristics (49%), descriptive studies of macro- or micronutrient intakes (41%), and interventional studies (11%). Findings consistently found growth impairment, especially among children and adolescents from sub-Saharan Africa. Studies assessing macro- and micronutrients generally had small sample sizes and were exploratory in nature. Only four randomized trials were identified, which measured the impact of lime juice, long-chain fatty acids supplementation, ready-to-use supplementary food, and oral arginine on health outcomes. Conclusions: The findings reveal a moderate number of descriptive studies, most with small sample sizes, that focused on various aspects of nutrition and SCD in African patients. There was a stark lack of interventional studies that could be used to inform evidence-based changes in clinical practice. Findings of investigations were generally consistent with data from other regional settings, describing a significant risk of growth faltering and malnutrition among individuals with SCD. There is an unmet need for clinical research to better understand the potential benefits of nutritional-related interventions for patients with SCD in sub-Saharan Africa in order to promote optimal growth and improve health outcomes.

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Section: Resultsmentioning

confidence: 99%

Nutritional perspectives on sickle cell disease in Africa: A systematic review

Nartey

Spector

Adu‐Afarwuah

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…[30] Additional studies similarly detected one or more growth de cits in adolescents but not in younger children. [35][36][37][38][39][40] In several Nigerian studies, SCD patients were found to be underweight or to have low BMI, but showed no difference in height compared to controls [33,38,[41][42][43][44]; while other Nigerian studies showed differences in both weight and height. [29,31,32,43,45,46] These variable ndings may have resulted from the fact that the studies were not powered to detect signi cant differences in height speci cally.…”

Section: Resultsmentioning

confidence: 99%

Nutritional Perspectives on Sickle Cell Disease in Africa: A Systematic Review

Nartey

Spector

Adu‐Afarwuah

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Sickle cell disease (SCD), an inherited blood disorder, predominantly affects individuals in sub-Saharan Africa. While there are established studies that links its pathophysiology and nutritional status, the extent of research in this area involving African patients has not been previously described. This systematic review aimed to assess the nutrition-focused landscape of SCD studies in Africa, summarize findings, and highlight gaps in knowledge that could inform priority-setting for future research.Methods: The study was conducted using the Preferred Reporting items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. We included all original studies, conducted between 1995 and 2018, on nutritional status of individuals with SCD in Africa. ‘Nutritional status’ was defined by studies on dietary intake, measurements of growth/anthropometry, and nutritional biomarkers. Studies of anemia in non-SCD individuals and those with sickle cell traits were excluded. Databases used were Ovid Embase, Medline, Biosis and Web of Science. Results: The search returned 366 articles from which 62 studies were included in the final analyses. Seventy percent of the investigations were conducted in Nigeria. Studies were categorized into one of three main categories: descriptive studies of anthropometric characteristics (50%), descriptive studies of macro- or micronutrient levels (35%), and interventional studies (15%). Findings consistently found growth impairment, especially among children and adolescents. Studies assessing macro- and micro-nutrients generally had small sample sizes and were exploratory in nature. Only two randomized placebo-controlled trials were identified, which measured the impact of fatty acid supplementation and lime juice on health outcomes. Conclusions: The findings reveal a moderate number of descriptive studies, with small sample size, that focused on various aspects of nutrition and sickle cell disease in African patients. There was a stark lack of interventional studies that could be used to inform evidence-based changes in clinical practice. Findings of investigations were generally consistent with data from other regional settings, describing a significant risk of growth faltering and malnutrition among individuals with SCD. There is an unmet need for clinical research to better understand the potential benefits of nutritional-related interventions for patients with SCD in sub-Saharan Africa in order to promote optimal growth and improve health outcomes.

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Section: Discussionunclassified

“…Çinko özellikle kırmızı ette yüksek oranda bulunur (15). Gelişmekte olan ülkelerde düşük oranda kırmızı et tüketimi ve yüksek oranda fitat içeren tahıllı gıdaların tüketilmesi nedeniyle Çinko eksikliğine sık rastlanmaktadır (15). Bu nedenle dünyanın farklı bölgelerinde hatta aynı ülkenin farklı alanlarında yapılmış çalışmalarda birbirinden farklı Çinko eksikliği oranları bulunmuştur (16)(17)(18).…”

Section: Discussionunclassified

The evaluation of zinc levels of preschool and school-aged children with iron deficiency: A cross-sectional case-control study

Kartal

Gürsel

2019

Zeynep Kamil Tıp Bülteni

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Dünyada hala ek sık gözlenen nutrisyonel eksiklikler demir ve Çinko eksiklikleridir. Günümüzde bu nutrisyonel eksiklikler sadece gelişmekte olan ülkelerin değil tüm dünyanın önemli bir problemidir. Bu çalışmanın amacı, okul öncesi ve okul çağında demir eksikliği olan çocuklarda serum Çinko seviyelerini karşılaştırmak ve eritrosit indekslerine olan etkilerini değerlendirmektir.

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Relationship between zinc levels and anthropometric indices among school-aged female children with sickle cell anemia in enugu, Nigeria

Abstract: Reduced serum zinc in SCA children was associated with low anthropometric indices. Estimation of serum zinc is also recommended in SCA children with low anthropometric indices.

Cited by 8 publications

References 2 publications

Nutritional perspectives on sickle cell disease in Africa: A systematic review

Nutritional perspectives on sickle cell disease in Africa: A systematic review

Nutritional Perspectives on Sickle Cell Disease in Africa: A Systematic Review

The evaluation of zinc levels of preschool and school-aged children with iron deficiency: A cross-sectional case-control study

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