Established amidst the bloodshed of the Civil War, land-grant universities, together with the associated agricultural experiment stations and cooperative extension services, have played a crucial role in democratizing scientific knowledge and addressing intertwined educational, environmental, economic, and democratic challenges within the USA. Indeed, they have arguably pioneered the idea of “usable science.” Today, the urgent challenges of the Anthropocene demand a more robust relationship between scientific research and on-the-ground action, strong networks sharing local lessons globally, and channels for injecting global, long-term perspectives into the noise of short-termism. The land-grant experience provides lessons for “Anthropocene universities” seeking to tackle these challenges, including the importance of (1) establishing or expanding university-based boundary organizations akin to cooperative extension, (2) incentivizing the integration of engagement into the university’s research, teaching, and service missions, (3) centering values of democracy, justice, equity, and inclusion in engagement, and (4) cooperating across institutions and sectors. Given the urgency of fully engaging academic institutions as players and connectors in the real-world challenges of addressing climate change and biodiversity loss, there is little time to waste.