The purpose of this case report is to describe, analyse and discuss the process and outcome of counselling a 38-year-old Taiwanese woman with infertility problems by a female Taiwanese counsellor who employed the relationship-centred counselling (RCC) approach. The client's long-standing fertility has been deeply connected to her symptoms of depression, anxiety, psychological and physiological pain, and social stress. During a 10-month counselling intervention, the client gradually minimized her physiological symptoms, reduced her negative emotions, improved her interpersonal relationships, built up her social support network, and enhanced her sense of internal control, self-esteem and satisfaction with life.