Relationship of Adiponectin to Serum Paraoxonase 1

Bajnok, L.; Csongradi, E.; Seres, I.; Varga, Zsolt; Jeges, S.; Peti, A.; Karányi, Z; Juhasz, A.; Mezosi, E.; Nagy, E.V.; Paragh, G.

doi:10.1016/s1567-5688(08)70084-9

Cited by 7 publications

(8 citation statements)

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“…The strong negative correlation found between arylesterase activity and serum leptin levels in female rats further support this idea ( R = −0.684, P = 0.029). The reduced serum PON1 activities in female rats are also in line with the reduction of adiponectin levels in this gender, showing a positive correlation ( R = 0.805, P = 0.02) that has also been reported in humans (53), thus suggesting that variations in serum adiponectin levels could also account for the reduced serum activity of the enzyme. Concerning the greater oxidative environment related to the cafeteria‐diet, it should be considered that both phospholipids and apoA‐I present in HDL are susceptible to oxidation, which has been related to impaired serum PON1 activity and protection of LDL from oxidation (54).…”

Section: Discussionsupporting

confidence: 79%

Gender Related Differences in Paraoxonase 1 Response to High‐fat Diet‐induced Oxidative Stress

Thomàs-Moyà

Gómez-Pérez

Fiol

et al. 2008

Obesity

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Objective: To evaluate the influence of the pro-oxidant and proinflammatory state related to dietary obesity on serum paraoxonase 1 (PON1) activity in male and female rats. Methods and Procedures: Adult Wistar rats of both genders were fed on a high-fat diet to induce weight gain or standard diet for 14 weeks. Body weight was assessed weekly and food intake fortnightly throughout the dietary treatment. Biometrical parameters and serum lipid profile, glucose, insulin, and adipokine levels were measured. To assess the effect of dietary obesity on oxidative stress, levels of liver and serum thiobarbituric acid reactive substances, liver protein carbonyl groups, liver antioxidant enzymes activities, and serum PON1 activities were measured. Results: High-fat diet feeding induced a significant body weight gain in both male and female rats, as well as a reduction of liver antioxidant protection. High-fat diet increased serum lipid peroxides in male rats and reduced serum PON1 activities and serum apolipoprotein A-I (apoA-I) levels in females, although did not alter serum PON1 or apolipoprotein J (apoJ) levels. Discussion: Our results reveal a gender dimorphism in the high-fat diet-induced reduction of serum PON1 activity, which is likely to be related to the greater obese and proinflammatory state achieved in female rats. We suggest that the enhanced oxidative stress caused by dietary increased body weight, on leading to high-density lipoprotein (HDL), apoA-I or PON1 oxidation could entail the destabilization of the PON1 association to HDL or a direct inactivation of PON1 enzymatic activity, thus accounting for the decreased serum PON1 activities observed in female rats.

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Section: Discussionsupporting

confidence: 79%

Gender Related Differences in Paraoxonase 1 Response to High‐fat Diet‐induced Oxidative Stress

Thomàs-Moyà

Gómez-Pérez

Fiol

et al. 2008

Obesity

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“…In addition to its role in energy storage, adipose tissue also secretes various biologically active adipokines such as leptin, and the anti-inflammatory and antiatherosclerotic adiponectin (25). Previous studies have shown correlations between the activity of PON1, and levels of adiponectin and leptin (3,(26)(27)(28). Moreover, the effect of inflammatory cytokines such as tumor necrosis factor-α, whose levels are higher in plasma of obese patients (29), deserves of future studies because they negatively affect PON1 synthesis (30).…”

Section: Discussionmentioning

confidence: 99%

HDL‐paraoxonase and Membrane Lipid Peroxidation: A Comparison Between Healthy and Obese Subjects

Ferretti

Bacchetti

Masciangelo

et al. 2010

Obesity

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High‐density lipoproteins (HDLs) play a key role in the protection against oxidative damage. The enzyme paraoxonase‐1 (PON1) associated at the surface of HDL modulates the antioxidant and anti‐inflammatory role of HDL. Previous studies have demonstrated a decrease of serum PON in obese patients. The aim of this study was to investigate whether modifications of PON1 activity reflect in a different ability to protect and/or repair biological membranes against oxidative damage. Thirty obese patients at different grades of obesity (BMI ranging from 30.4 to 64.0 kg/m2) and 62 age‐matched control subjects (BMI <25 kg/m2) were included in the study. The ability of HDL to protect membranes against oxidative damage was studied using erythrocyte membranes oxidized with 2,2‐azobis(2 amidinopropane)dihydrochloride (AAPH) (ox‐membrane). The membrane lipid hydroperoxide levels were evaluated after the incubation of ox‐membranes in the absence or in the presence of HDL of controls or obese patients. The results confirm that HDL exerts a protective effect against lipid peroxidation. The ability of HDL to repair erythrocyte membranes was positively correlated with HDL‐PON activity and negatively correlated with lipid hydroperoxide levels in HDL. These results suggest that PON modulates the HDL repairing ability. HDL from obese patients repaired less efficiently erythrocyte membranes against oxidative damage with respect to HDL from healthy subjects. A negative relationship has been established between BMI of obese patients and the protective effect of HDL. In conclusion, the decrease of HDL‐PON activity and the lower HDL protective action against membrane peroxidation in obese patients could contribute to accelerate the cellular oxidative damage and arteriosclerosis in obesity.

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“…Since several in vivo and in vitro studies have reported that adiponectin has direct anti-atherogenic effects on the arterial wall (Matsuda et al Alteration of PON1 Activity in Adult and Childhood Obesity 2002) and that hypoadiponectinemia was associated with endothelial dysfunction (Shimabukuro et al 2003), cardiovascular disease (Kumada et al 2003) and diabetes mellitus (Hotta et al 2000), we hypothesized that there might be correlations between antioxidant PON1 activities and adiponectin levels. We analyzed the relationship of adiponectin concentration to PON1 activity (Bajnok et al 2008a). To the best of our knowledge this was the first study to investigate the relationship between PON1 activity and adiponectin levels.…”

Section: Relationship Of Adiponectin To Pon1mentioning

confidence: 99%

Alteration of PON1 Activity in Adult and Childhood Obesity and Its Relation to Adipokine Levels

Serés

Bajnok

Harangi

et al. 2009

Advances in Experimental Medicine and Biology

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Obesity as a pathogenic disorder is a predisposing factor for cardiovascular diseases and shows an increasing incidence in the industrialized countries. Adipokines such as leptin, adiponectin and resistin have a great impact on the development of atherosclerosis in obesity. Elevated levels of leptin have been found to be atherogenic whereas decreased levels of adiponectin have been proved to be anti-atherogenic in recent studies. The exact role of resistin in the process of atherosclerosis has so far remained uncertain and controversial. In our recent work, we studied the alteration in human paraoxonase-1 (PON1) activity and adipokine levels; furthermore, we also aimed at identifying the potential correlation between these parameters in this metabolic disorder. We investigated the abovementioned parameters both in adults and in children, with regard to the emerging role of childhood obesity and to get a clearer view of these factors during a whole lifetime. Investigating the adult population with a broad range of body mass index (BMI) we found significantly increased leptin and significantly decreased adiponectin and resistin levels and PON1 activity in the obese group compared to the lean controls. Adiponectin and resistin levels showed significantly positive correlation, while leptin and BMI showed significantly negative correlation with PON1 activity.Our findings were similar in childhood obesity: leptin showed significantly negative correlation, while adiponectin showed significantly positive correlation with PON1 activity. We found gender differences in the univariate correlations of leptin and adiponectin levels with PON1 activity in the adult population. In multiple regression analysis, adiponectin proved to be an independent factor of PON1 activity both in childhood and adult obesity, furthermore thiobarbituric acid-reactive substances (TBARS) also proved to be an independent predictor of the enzyme in adults, reflecting the important role of oxidative stress in obesity. Investigating PON 192 Q/R polymorphism by phenotypic distribution (A/B isoenzyme) in obese children, we found a significant correlation of PON1 arylesterase activity with leptin and adiponectin levels, and of body fat percentage with PON1 192 B isoenzyme.According to our studies, these metabolic changes in obesity predispose to the early development of atherosclerosis throughout our whole lifetime. Decreased activity of PON1 and alterations in adipokine levels in childhood obesity could contribute to an early commencement of this process, detected only later in adulthood by increased cardiovascular morbidity and mortality. Changed levels of leptin, adiponectin, resistin and PON1 activity at all ages, just like 192 Q/R polymorphism determined by phenotypic distribution, may be useful markers beside the general risk factors.Keywords (separated by '-') Adipokines -Leptin -Adiponectin -Resistin -Obesity -Paraoxonase-1 -Childhood Abstract Obesity as a pathogenic disorder is a predisposing factor for cardiovascular diseases and shows a...

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Relationship of Adiponectin to Serum Paraoxonase 1

Cited by 7 publications

References 0 publications

Gender Related Differences in Paraoxonase 1 Response to High‐fat Diet‐induced Oxidative Stress

Gender Related Differences in Paraoxonase 1 Response to High‐fat Diet‐induced Oxidative Stress

HDL‐paraoxonase and Membrane Lipid Peroxidation: A Comparison Between Healthy and Obese Subjects

Alteration of PON1 Activity in Adult and Childhood Obesity and Its Relation to Adipokine Levels

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