Relationship of alcohol abuse history to nighttime hypoxemia in abstaining chronic alcoholic men.

Vitiello, Michael V.; Prinz, Patricia N.; Personius, Janelle P.; Vitaliano, Peter P.; Nuccio, Maureen A.; Koerker, D Richard

doi:10.15288/jsa.1990.51.29

Cited by 14 publications

(4 citation statements)

References 12 publications

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“…There is also an increase in the number of sleep apnea episodes with advancing age and among patients with hypo thyroidism. Intake of benzodiazepines and al cohol shortly before bedtime is known to result in snoring and increasing numbers of episodes of obstructive apnea during sleep [6,7], There are also reports of apnea in formerly alcoholic men who abstain [8,9].…”

Section: Occupational Exposure To Organic Solvents and Sleep-disordermentioning

confidence: 99%

“…It is reported that exposure to organic solvents may lead to dysfunction of the autonomic nervous system and damage the peripheral nervous system [25,26]. Tan et al [8] and Vitiello et al [9] hypothesized that chronic heavy alcohol consumption creates sleep apnea through deterioration of the vagus function and peripheral neuropathy. Perhaps alcohol, an organic solvent, and other types of organic solvents operate in a similar manner to produce a dysfunction of the upper airway pathways during sleep.…”

Section: Organic Solvents and Sleep-disordered Breathingmentioning

confidence: 99%

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Occupational Exposure to Organic Solvents and Sleep-Disordered Breathing

et al. 1997

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Study objective: To investigate whether people with occupational exposure to organic solvents have a higher prevalence of obstructive sleep apnea syndrome (OSAS) than the general population and to examine the relationship between snoring and exposure to organic solvents. Design and participants: Consecutive patients, aged 30-64 years, referred during a 3-year period to the sleep laboratory at Avesta Hospital, Sweden, because of suspected OSAS made up the patient groups. Following admission, patients underwent a simplified sleep apnea investigation and were divided into two groups, OSAS (n = 320) and snorers (n = 443). A random sample of 296 men and 289 women aged 30–64 years obtained from a register of all county residents maintained by the county tax authority served as referents (controls). Both patients and referents responded to two questionnaires, including questions about occupation, exposure to organic solvents, and other chemical and physical agents. Results: Men with OSAS or snoring and women with snoring had more often been occupationally exposed to organic solvents than the referents, showing an almost twofold increase in risk for those exposed during whole workdays. For men, the risk of OSAS or snoring increased with increasing exposure. Conclusion: The result indicates that occupational exposure to organic solvents might cause sleep apnea. A new observation is that even snoring could be caused by exposure to organic solvents. It is important to elucidate whether exposure to organic solvents is a cause of OSAS, because such a finding may have important implications for prevention and treatment of sleep disturbances.

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Section: Occupational Exposure To Organic Solvents and Sleep-disordermentioning

confidence: 99%

Section: Organic Solvents and Sleep-disordered Breathingmentioning

confidence: 99%

Occupational Exposure to Organic Solvents and Sleep-Disordered Breathing

et al. 1997

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“…Smoking is related to snoring, 6,7 which is considered to be a preclinical form of sleep-disordered breathing. Smoking has also been associated with concomitants of sleepdisordered breathing such as nocturnal hypoxemia 8 and complaints of disturbed sleep. 9 Evidence for a relationship between smoking and sleep-disordered breathing would have important clinical and public health implications.…”

mentioning

confidence: 99%

Higher Prevalence of Smoking in Patients Diagnosed as Having Obstructive Sleep Apnea

2001

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Nightly nicotine withdrawal as well as other respiratory and pulmonary effects of smoking may result in sleep-disordered breathing, especially obstructive sleep apnea (OSA). We hypothesize that there is higher prevalence of smoking in patients with OSA. We also hypothesize that smoking is an independent risk factor for OSA. The aim of this study is to determine whether there is a higher prevalence of smoking in patients with OSA compared with patients who do not have OSA. To investigate this, we randomly selected a group of 108 patients who were diagnosed as having OSA, defined by an apnea-hypopnea index (AHI) of greater than 10 events per hour. We compared their smoking history with another randomly selected group of 106 patients without OSA, defined by an AHI of less than five events per hour. The prevalence of smoking in patients with OSA was found to be 35%, whereas it was only 18% in patients without OSA. Logistic regression analyses were performed to investigate the effects of smoking while adjusting for age, gender, body mass index (BMI), and number of alcoholic drinks per week. While holding fixed the BMI, gender, age, and number of alcoholic drinks per week, current smokers were found to be 2.5 times more likely to have OSA than former smokers and nonsmokers combined (odds ratio = 2.5, CI 1.3-4.7, p = 0.0049), and 2.8 times more likely to have OSA than former smokers alone (odds ratio = 2.8, CI = 1.4-5.4, p = 0.0028). Adjusted for BMI, gender, age, and number of alcoholic drinks per week, former smokers were not more likely than never smokers to have OSA (odds ratio = 1.2, CI = 0.55-2.7, p = 0.64). We conclude that cigarette smoke may be an independent risk factor for OSA in this referral population.

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“…While it is not entirely clear why veterans with PTSD present with higher rates of OSA compared to nonveterans without PTSD (Colvonen et al, 2015), there is convincing evidence that long-term alcohol ingestion and opioid use are important factors in pathogenesis of OSA (Le Bon et al, 1997; Vitiello et al, 1990; Wang & Teichtahl, 2007). For example, even after a single drink, normal sleepers can develop snoring and even exhibit breathing events resulting in oxygen desaturations (Block & Hellard, 1987).…”

mentioning

confidence: 99%

Diagnosing obstructive sleep apnea in a residential treatment program for veterans with substance use disorder and PTSD.

Colvonen¹,

Rivera²,

Straus³

et al. 2022

Psychological Trauma: Theory, Research, Practice, and

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Background: Obstructive sleep apnea (OSA) is often comorbid with both substance use disorders (SUD) and posttraumatic stress disorder (PTSD), yet frequently goes undiagnosed and untreated. We present data on the feasibility and acceptability of objective OSA diagnosis procedures, findings on OSA prevalence, and the relationship between OSA and baseline SUD/PTSD symptoms among veterans in residential treatment for comorbid PTSD/SUD. Methods: Participants were 47 veterans admitted to residential PTSD/SUD treatment. Participants completed questionnaires assessing PTSD and sleep symptoms, and filled out a sleep diary for seven days. Apnea-hypopnea index (AHI) was recorded using the overnight Home Sleep Apnea test (HSAT; OSA was diagnosed with AHI $ 5). Results: Objective OSA diagnostic testing was successfully completed in 95.7% of participants. Of the 45 veterans who went through HSAT, 46.7% had no OSA, 35.6% received a new OSA diagnosis, and 8.9% were previously diagnosed with OSA and were using positive airway pressure treatment (PAP); an additional 8.9% were previously diagnosed with OSA, reconfirmed with the HSAT, but were not using PAP. One hundred percent of respondents during follow-up deemed the testing protocol's usefulness as "Good" or "Excellent." Conclusion: OSA diagnostic testing on the residential unit was feasible and acceptable by participants and was effective in diagnosing OSA. OSA testing should be considered for everyone entering a SUD and PTSD residential unit. Clinical Impact StatementObstructive sleep apnea (OSA) is very often comorbid with both posttraumatic stress disorder (PTSD) and substance use disorders (SUD). Unfortunately, due to the limitations of self-report OSA screeners and atypical presentation of OSA in individuals with SUD/PTSD, OSA often goes undiagnosed for individuals with SUD/PTSD. Our study found that OSA diagnostic testing was feasible and acceptable to participants in a residential treatment program for SUD/PTSD, and effective in diagnosing OSA. Diagnosing OSA on a residential unit for SUD/PTSD is a necessary first step to treating OSA and may help improve long-term outcomes for individuals with SUD/PTSD.

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Relationship of alcohol abuse history to nighttime hypoxemia in abstaining chronic alcoholic men.

Cited by 14 publications

References 12 publications

Occupational Exposure to Organic Solvents and Sleep-Disordered Breathing

Occupational Exposure to Organic Solvents and Sleep-Disordered Breathing

Higher Prevalence of Smoking in Patients Diagnosed as Having Obstructive Sleep Apnea

Diagnosing obstructive sleep apnea in a residential treatment program for veterans with substance use disorder and PTSD.

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