1970
DOI: 10.3329/bjms.v8i1.3183
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Relationship of anti-fertility effects of <i>Andrographis paniculata</i> and hormonal assay in female rats

Abstract: Aims: This study was aimed to find out anti-fertility effects of Andrographis paniculata (AP) plant. Study design & Methodology: A prospective case control animal study with 85 female and 30 male rats (Total 115 rats) was done in the Department of Pharmacology of Dhaka Medical College and Bangladesh Medical College, Dhaka, Bangladesh from July 2002 to December 2003. The total 85 female rats were grouped into case study or exposure group (N=60 female rats) exposed to water extract of AP & control or non exposur… Show more

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Cited by 8 publications
(8 citation statements)
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“…Extensive 46 research revealed that A. paniculata has a surprisingly broad range of pharmacological effects and some of them are extremely beneficial and include anticancer (Kumar et al, 2004), anti HIV (Chang andYeung, 1988), anti AIDS (Stephen and Comac, 2000), hepatoprotective (Handa and Sharma, 1990) and immunostimulatory (Puri et al, 1993). Other pharmacological effects include; antimalarial (Misra et al, 1992), antityphoid (Sabu, 2006), antiviral (Wiart et al, 2005), antifungal (Sabu, 2006), antibacterial (Mishra et al, 2009), antidiarrhoeal (Gupta et al, 1993), antipyretic (Vedavathy andRao, 1991), antiinflammatory (Chang andBut, 1986), antidiabetic (Zhang and Tan, 2000), antithrombotic (Yeung et al, 1987), cardiovascular Zhang, 2004), antivenom (Chang andBut, 1986), antifertility (Sakila et al, 2009) and psychopharmacological activity (Mandal et al, 2001). A. paniculata may be a promising treatment for the alleviation of subjective symptoms of respiratory tract infections (Coon and Ernst, 2004).…”
Section: Introductionmentioning
confidence: 99%
“…Extensive 46 research revealed that A. paniculata has a surprisingly broad range of pharmacological effects and some of them are extremely beneficial and include anticancer (Kumar et al, 2004), anti HIV (Chang andYeung, 1988), anti AIDS (Stephen and Comac, 2000), hepatoprotective (Handa and Sharma, 1990) and immunostimulatory (Puri et al, 1993). Other pharmacological effects include; antimalarial (Misra et al, 1992), antityphoid (Sabu, 2006), antiviral (Wiart et al, 2005), antifungal (Sabu, 2006), antibacterial (Mishra et al, 2009), antidiarrhoeal (Gupta et al, 1993), antipyretic (Vedavathy andRao, 1991), antiinflammatory (Chang andBut, 1986), antidiabetic (Zhang and Tan, 2000), antithrombotic (Yeung et al, 1987), cardiovascular Zhang, 2004), antivenom (Chang andBut, 1986), antifertility (Sakila et al, 2009) and psychopharmacological activity (Mandal et al, 2001). A. paniculata may be a promising treatment for the alleviation of subjective symptoms of respiratory tract infections (Coon and Ernst, 2004).…”
Section: Introductionmentioning
confidence: 99%
“…Sakila et al [137] conducted an antifertility study and found no toxicity, even at a high dose of A. paniculata that was administered to rats. The LD50 of andrographolide in male mice through the intraperitoneal route was reported to be 11.46 g/kg [138].…”
Section: Dosage and Safety Of Andrographolidementioning
confidence: 99%
“…Furthermore, Sattayasai et al (2010) reported the aphrodisiac-like effect of AP is comparable to sildenafil. Since earlier studies reported the effects of AP on fertility either negative (Akbarsha & Muragaian 2000;Akbarsha et al 1990;Sakilah et al 2009;Zoha et al 1989), positive (Mkrtchyan et al 2005;Sattayasai et al 2010) or no effect (Burgos et al 1997), therefore the present study was carried out to further clarify the effect of AP on male rat fertility.…”
Section: Introductionmentioning
confidence: 99%
“…In male rats, AP caused arrest in spermatogenesis, decreased sperm count and motility and several of them possessed abnormalities in sperm morphology (Akbarsha & Muragaian 2000;Akbarsha et al 1990). Sakilah et al (2009) reported that AP caused infertility in female rats due to lower level of reproductive hormones such as FSH, LH, estrogen and progesterone. On the other hand, Burgos et al (1997) reported that AP dried extracts demonstrated no subchronic testicular toxic effects and morphological or functional changes in Leydig cells.…”
Section: Introductionmentioning
confidence: 99%
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