Relationship of brain levels of norepinephrine and dopamine to avoidance behavior in rats after intraventricular administration of 6-hydroxydopamine

Lenard, Lane G.; Beer, Bernard

doi:10.1016/0091-3057(75)90123-9

Cited by 28 publications

(8 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, it is still unclear whether this distinction is relevant to the effects of these drugs on CAR. Early reports of disruption of CAR following depletion of striatal DA with 6-OHDA (e.g., Fibiger et al 1974, Lenard andBeer 1975) did not exclude possible contributions of other DA terminal regions. Koob et al (1984) found that 6-OHDA lesions in both striatum and nucleus accumbens were required to block CAR.…”

Section: Discussionmentioning

confidence: 97%

Blockade of acquisition of one-way conditioned avoidance responding by haloperidol and metoclopramide but not by thioridazine or clozapine: implications for screening new antipsychotic drugs

Blackburn

Phillips

1989

Psychopharmacology

View full text Add to dashboard Cite

The classical neuroleptic drugs haloperidol and pimozide have a strong disruptive effect on the acquisition of conditioned avoidance responding (CAR), yet have relatively little impact on the performance of previously acquired responses. Separate experiments compared the effects of haloperidol, two atypical neuroleptics, thioridazine and clozapine, and a substituted benzamide, metoclopramide, on one-way avoidance by rats. Thioridazine (10-50 mg/kg) and clozapine (1.25-10.0 mg/kg) disrupted both acquisition and performance of CAR. In contrast, haloperidol (0.075-0.150 mg/kg) and metoclopramide (5.0-7.5 mg/kg) completely blocked the acquisition of CAR, yet initially produced only a slight disruption in the performance of a previously acquired response. The ineffectiveness of the atypical neuroleptics in producing a complete disruption of acquisition of CAR may be due to the anticholinergic properties of these drugs. Alternatively, the differences between metoclopramide and the atypical neuroleptics may be due to a preferential effect of metoclopramide on striatal or amygdaloid dopamine neurotransmission. These results suggest that caution should be exercised in using CAR as an animal model for assessing the antipsychotic potential of new pharmacological agents.

show abstract

Section: Discussionmentioning

confidence: 97%

Blockade of acquisition of one-way conditioned avoidance responding by haloperidol and metoclopramide but not by thioridazine or clozapine: implications for screening new antipsychotic drugs

Blackburn

Phillips

1989

Psychopharmacology

View full text Add to dashboard Cite

show abstract

“…Early studies on the neurobiology of active avoidance also focused on catecholamine systems (Beer and Lenard, 1975; Ashford and Jones, 1976; Fibiger and Mason, 1978; Oei and King, 1978; Raskin et al, 1983; Koob et al, 1984). In general, DA has mostly been implicated in the acquisition and expression of avoidance responses (Lenard and Beer, 1975; Fibiger and Mason, 1978) while NE may be more involved in the extinction of such responses (Lenard and Beer, 1975; Fibiger and Mason, 1978; Raskin et al, 1983). However, selective lesions that targeted either the DA or NE system have yielded inconsistent results.…”

Section: Discussionmentioning

confidence: 99%

“…However, selective lesions that targeted either the DA or NE system have yielded inconsistent results. For instance, NE depletion did not appreciably alter avoidance learning, but rather led to impairment of extinction (Lenard and Beer, 1975; Fibiger and Mason, 1978), while mice that lacked NE extinguished more rapidly compared to intact CTLs (Thomas and Palmiter, 1997). The inconsistent effects of lesions may be due to different lesion procedures and compensatory mechanisms after lesion.…”

Section: Discussionmentioning

confidence: 99%

Effects of Psychotropic Agents on Extinction of Lever-Press Avoidance in a Rat Model of Anxiety Vulnerability

Jiao

Beck

Stewart

et al. 2014

Front. Behav. Neurosci.

View full text Add to dashboard Cite

Avoidance and its perseveration represent key features of anxiety disorders. Both pharmacological and behavioral approaches (i.e., anxiolytics and extinction therapy) have been utilized to modulate avoidance behavior in patients. However, the outcome has not always been desirable. Part of the reason is attributed to the diverse neuropathology of anxiety disorders. Here, we investigated the effect of psychotropic drugs that target various monoamine systems on extinction of avoidance behavior using lever-press avoidance task. Here, we used the Wistar-Kyoto (WKY) rat, a unique rat model that exhibits facilitated avoidance and extinction resistance along with malfunction of the dopamine (DA) system. Sprague Dawley (SD) and WKY rats were trained to acquire lever-press avoidance. WKY rats acquired avoidance faster and to a higher level compared to SD rats. During pharmacological treatment, bupropion and desipramine (DES) significantly reduced avoidance response selectively in WKY rats. However, after the discontinuation of drug treatment, only those WKY rats that were previously treated with DES exhibited lower avoidance response compared to the control group. In contrast, none of the psychotropic drugs facilitated avoidance extinction in SD rats. Instead, DES impaired avoidance extinction and increased non-reinforced response in SD rats. Interestingly, paroxetine, a widely used antidepressant and anxiolytic, exhibited the weakest effect in WKY rats and no effects at all in SD rats. Thus, our data suggest that malfunctions in brain catecholamine system could be one of the underlying etiologies of anxiety-like behavior, particularly avoidance perseveration. Furthermore, pharmacological manipulation targeting DA and norepinephrine may be more effective to facilitate extinction learning in this strain. The data from the present study may shed light on new pharmacological approaches to treat patients with anxiety disorders who are not responding to serotonin re-uptake inhibitors.

show abstract

“…This level is upregulated in the course of their maturation, indicating to necessity of being in permanent state of activity and alertness to confront possible aggression [35]. Moreover, in the model experiments with artificial upregulation of noradrenergic system in the brain structures, linear correlation between level of noradrenalin in the brain and level of social avoidance was revealed [35,36]. In the juveniles, bred in the pools, in conditions of food abundance and lack of predators, low levels of noradrenalin in the brain, really suppressing completely the state of alertness and reaction of escape from predators, are noticed.…”

Section: Discussionmentioning

confidence: 90%

Comparative Studies of Several Physiologic and Biochemical Indexes of Wild Type and Hatchery-Bred Sturgeons in the Early Ontogenesis

Ryu¹,

Uf²,

Cha³

et al. 2017

Fish Aquac J

View full text Add to dashboard Cite

It was shown that, depending on the ways of breeding and living conditions, realization of food-seeking and defensive behavioural reactions as well as single biochemical indexes (pattern of neurotransmitters and levels of free amino acids in the brain) in the wild type and hatchery-bred sturgeon juveniles differ significantly. Basing on the studied indexes, the juveniles, bred in the ponds, are close to the wild type juveniles, whereas the juveniles, bred by pool technique, are quite different from them.

show abstract

Relationship of brain levels of norepinephrine and dopamine to avoidance behavior in rats after intraventricular administration of 6-hydroxydopamine

Cited by 28 publications

References 7 publications

Blockade of acquisition of one-way conditioned avoidance responding by haloperidol and metoclopramide but not by thioridazine or clozapine: implications for screening new antipsychotic drugs

Blockade of acquisition of one-way conditioned avoidance responding by haloperidol and metoclopramide but not by thioridazine or clozapine: implications for screening new antipsychotic drugs

Effects of Psychotropic Agents on Extinction of Lever-Press Avoidance in a Rat Model of Anxiety Vulnerability

Comparative Studies of Several Physiologic and Biochemical Indexes of Wild Type and Hatchery-Bred Sturgeons in the Early Ontogenesis

Contact Info

Product

Resources

About