Relationship of Breast Cancer with Ovarian Cancer

Çelik, Ayşe; Acar, Muradiye; Erkul, Catherine Moroski; Gündüz, Esra; Gündüz, Mehmet

doi:10.5772/59682

Cited by 7 publications

(6 citation statements)

References 75 publications

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“…3 Currently, BRCA1/2 mutation, PTEN, and p53 analysis are being studied to uncover organotropism including predictive analysis of HRs to investigate the molecular subtype of breast and ovarian cancers that can metastasize to distant organs using immunohistochemical staining or microarrays. 8,14,16 Although, early prediction of organotropism can decrease the incidence of cancer-related mortality in women, these clinical methods are invasive and expensive. 32 Similarly, neoadjuvant chemotherapy of sensitive/resistant proteins has been studied to determine effective treatments.…”

Section: Discussionmentioning

confidence: 99%

“…12,13 Although breast and ovarian cancers are clinically distinct, mutations in tumor suppressor genes (BRCA1/2, p53, and PTEN) and proto-oncogenes, and changes in hormone regulation and microenvironment, indicate the similarities between breast and ovarian cancer. 14 To date, studies have focused on miRNA expression 15 mutations in breast cancer susceptibility genes BRCA1/2, 16 and tumor suppressor genes, such as PTEN and P53, 14 to uncover and predict the metastatic organotropism patterns of breast and ovarian cancers.…”

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confidence: 99%

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In search of the altering salivary proteome in metastatic breast and ovarian cancers

2019

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Breast and ovarian cancers, the most common cancers in women in India, are expected to rise in the next decade. Metastatic organotropism is a nonrandom, predetermined process which represents a more lethal and advanced form of cancer with increased mortality rate. In an attempt to study organotropism, salivary proteins were analyzed by mass spectrometry indicative of pathophysiology of breast and ovarian cancers and were compared to healthy and ovarian chemotherapy subjects. Collectively, 646 proteins were identified, of which 409 proteins were confidently identified across all four groups. Network analysis of upregulated proteins such as coronin‐1A, hepatoma‐derived growth factor, vasodilator‐stimulated phosphoprotein (VASP), and cofilin in breast cancer and proteins like coronin‐1A, destrin, and HSP90α in ovarian cancer were functionally linked and were known to regulate cell proliferation and migration. Additionally, proteins namely VASP, coronin‐1A, stathmin, and suprabasin were confidently identified in ovarian chemotherapy subjects, possibly in response to combined paclitaxel and carboplatin drug therapy to ovarian cancer. Selected representative differentially expressed proteins (eg, gelsolin, VASP) were validated by western blot analysis. Results of this study provide a foundation for future research to better understand the organotropic behavior of breast and ovarian cancers, as well as neoadjuvant drug response in ovarian cancer.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

In search of the altering salivary proteome in metastatic breast and ovarian cancers

2019

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“…This association is driven by epigenetic changes as well as environmental factors acting as potential triggers [ 27 ]. A family history of ovarian cancer—especially those characterized by BRCA1 and BRCA2 mutations—might also induce a greater risk of breast cancer [ 28 ].…”

Section: Risk Factors Of Breast Cancermentioning

confidence: 99%

Breast Cancer—Epidemiology, Risk Factors, Classification, Prognostic Markers, and Current Treatment Strategies—An Updated Review

Łukasiewicz

Czeczelewski

Forma

et al. 2021

Cancers

904

405

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Breast cancer (BC) is the most frequently diagnosed cancer in women worldwide with more than 2 million new cases in 2020. Its incidence and death rates have increased over the last three decades due to the change in risk factor profiles, better cancer registration, and cancer detection. The number of risk factors of BC is significant and includes both the modifiable factors and non-modifiable factors. Currently, about 80% of patients with BC are individuals aged >50. Survival depends on both stage and molecular subtype. Invasive BCs comprise wide spectrum tumors that show a variation concerning their clinical presentation, behavior, and morphology. Based on mRNA gene expression levels, BC can be divided into molecular subtypes (Luminal A, Luminal B, HER2-enriched, and basal-like). The molecular subtypes provide insights into new treatment strategies and patient stratifications that impact the management of BC patients. The eighth edition of TNM classification outlines a new staging system for BC that, in addition to anatomical features, acknowledges biological factors. Treatment of breast cancer is complex and involves a combination of different modalities including surgery, radiotherapy, chemotherapy, hormonal therapy, or biological therapies delivered in diverse sequences.

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“…This association is potentially triggered by epigenetic changes as well as environmental factors [66]. Women with family history of ovarian cancer with BRCA genes mutation may also induce a risk of breast carcinogenesis [67]. However, a study in a hospital among 5,359 women, found no association between the family history of breast cancer and; the mortality and severity of the patients with breast cancer [68].…”

Section: Family Historymentioning

confidence: 99%

Breast cancer: Risk factors and prevention strategies

Das¹

2022

World J. Bio. Pharm. Health Sci.

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Among the cancer diseases, breast cancer is becoming fast growing leading cause of oncologic mortality among women. It is hoped that, evaluation of different dimensions of breast cancer and its associated factors such as environmental and genetic factors, will increase the efforts of prevention. Current studies suggest that mutations in some genes play an crucial role in susceptibility of breast cancer. Thus, researchers aimed to isolate such breast cancer susceptible genes. Some epidemiologic studied also suggested that, moderate to vigorous exercise for 3-4 hours per week can lower the risk for breast cancer for 30%-40% in women than those of the sedentary women. Obese or overweight women have 50%-250% greater risk for breast cancer after menopause. Alcohol use also increases the risk of both postmenopausal and premenopausal breast cancer. Thus, these trends of sedentary lifestyle, decreasing physical activity and increasing obesity may lead to an increase in the incidence of breast cancer. Thus, adoption of healthy food habits, increasing physical activity and changes in sedentary lifestyle may have a great impact on the prevalence of this disease in future. The treatment strategies for breast cancer are broad-ranging depending on tumor’s biology; stages of the disease; tolerance, and acceptance of the patient. There is various treatment approaches of breast cancer such as radiology, surgery, and systematic therapy (chemotherapy, endocrine therapy and biological therapy) etc. In this article required information about risk factors and current breast cancer prevention strategies are collected through literature review.

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Relationship of Breast Cancer with Ovarian Cancer

Cited by 7 publications

References 75 publications

In search of the altering salivary proteome in metastatic breast and ovarian cancers

In search of the altering salivary proteome in metastatic breast and ovarian cancers

Breast Cancer—Epidemiology, Risk Factors, Classification, Prognostic Markers, and Current Treatment Strategies—An Updated Review

Breast cancer: Risk factors and prevention strategies

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