Relationship of C-reactive protein with components of the metabolic syndrome in a Tunisian population

Belfki, Hanen; Ali, Samir Ben; Bougatef, Souha; Ahmed, Decy Ben; Haddad, Najet; Jmal, Awatef; Abdennebi, Monia; Romdhane, Habiba Ben

doi:10.1016/j.ejim.2011.10.011

Cited by 19 publications

(13 citation statements)

References 47 publications

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“…It has been reported that MS is present in approximately one third of patients with hypertension [28]. We found also that circulating concentrations of CRP were increased according to obesity, with higher values in Ob-MS group (p<0.001) compared to the Ob group, which is in line with other studies [29,30], showing simultaneous increasing levels of circulating CRP, TNF-α and IL-6 depending on the presence of the MS and diabetes. But the mechanism linking leptin and CRP is yet to be explained.…”

Section: Discussionsupporting

confidence: 92%

Leptin, Insulin and Lipid Profiles in Obese Subjects with and without Metabolic Syndrome in the Region of Cap-Bon: Tunisia

Gannar¹,

A²,

Ferid³

2015

Endocrinol Metab Syndr

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Aims: To evaluate the effect of obesity associated or not with Metabolic Syndrome (MS) on leptinemia, insulinemia and lipid profile in subjects from the region of Cap-Bon in northeastern Tunisia. Methods: Ninety seven individuals were included in this study. Anthropometric parameters (Body Mass Index (BMI), Waist Circumference (WC) and Hip Circumference (HC), metabolic parameters (Total Cholesterol (TC), LDL-C, HDL-C, Non-Esterified Fatty Acids (NEFA), Triglycerides (TG), C˗Reactive Protein (CRP), glucose) and hormones (insulin and leptin) were determined. Insulin resistance was estimated by Homeostasis Model Assessment of Insulin Resistance (HOMA-IR). Metabolic syndrome was identified with the International Diabetes Federation (IDF) criteria. Results: Obese patients with and without MS, Ob-MS and Ob groups, have significantly increased plasma levels of glucose, TG, TC, LDL-C and decreased HDL-C. In obese subjects Ob and Ob-MS, plasma levels of insulin and the HOMA-IR index were increased especially when obesity is associated with MS, conversely to leptin which decreases slightly in the presence of MS. Leptinemia was positively correlated with BMI in the whole population. But, we did not find any correlation between leptinemia and HOMA-IR. In controls, plasma leptin concentrations were positively correlated to LDL-C (p<0.05). Conclusion: Our findings support the link between leptinemia in obesity, associated or not with MS. However, in the Tunisian population plasma leptin was not associated to insulin profile.

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Section: Discussionsupporting

confidence: 92%

Leptin, Insulin and Lipid Profiles in Obese Subjects with and without Metabolic Syndrome in the Region of Cap-Bon: Tunisia

Gannar¹,

A²,

Ferid³

2015

Endocrinol Metab Syndr

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“…Consequently, those people have more cholesterol circulating in the plasma compartment, and this cholesterol is likely to be deposited in the arterial wall, provoking atherogenesis and risk of cardiovascular events [19,20]. Our findings were consistent with others publications where these ratios were found to be related to MetS and its components [19,20,[24][25][26].…”

Section: Discussionsupporting

confidence: 92%

Moroccan Obese Patients with or without Metabolic Syndrome: Dietary Pattern and Risk of Cardiovascular Disease

Benalioua¹,

Mohtadi²,

Msaad³

et al. 2018

jnhfs

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More importantly, an effort must be made to strike at the underlying causes of the metabolic syndrome. Certainly, reversal of the worldwide epidemic of obesity and physical inactivity must be a high priority. But in addition, better means to treat underlying susceptibility to the metabolic syndrome to ovoid CVD also are needed. Both approaches represent a great challenge to research in the cardiovascular and metabolic syndrome fields and their association with nutrition.

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“…In line with previous studies (Ghayour-Mobarhan et al 2005;Nahas et al 2009;Wildman et al 2011;Belfki et al 2012), we found that CRP concentrations rose with an increase in the number of features of MetS. These other investigators have also reported a positive correlation between CRP and fasting glucose, HOMA-IR, triglycerides, and blood pressure and a negative correlation with HDL cholesterol.…”

Section: Discussionsupporting

confidence: 82%

The 60- and 70-kDa heat-shock proteins and their correlation with cardiovascular risk factors in postmenopausal women with metabolic syndrome

Nahás

Orsatti

Tardivo

et al. 2014

Cell Stress and Chaperones

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We investigated the association between circulating levels of 60 and 70 kDa heat-shock proteins (HSP60 and 70) and cardiovascular risk factors in postmenopausal women with or without metabolic syndrome (MetS). This crosssectional study included 311 Brazilian women (age ≥45 years with amenorrhea ≥12 months). Women showing three or more of the following diagnostic criteria were diagnosed with MetS: waist circumference (WC) ≥88 cm, blood pressure ≥130/ 85 mmHg, triglycerides ≥150 mg/dl, high-density lipoprotein (HDL) <50 mg/dl, and glucose ≥100 mg/dl. Clinical, anthropometric, and biochemical parameters were collected. HSP60, HSP70, antibodies to HSP60 and HSP70, and C-reactive protein (CRP) levels were measured in serum. Student's t test, Kruskal-Wallis test, chi-square test, and Pearson correlation were used for statistical analysis. Of the 311 women, 30.9 % (96/311) were diagnosed with MetS. These women were, on average, obese with abdominal fat deposition and had lower HDL values as well as higher triglycerides and glucose levels. Homeostasis model assessment-insulin resistant (HOMA-IR) test values in these women were compatible with insulin resistance (P <0.05). CRP and HSP60 concentrations were higher in women with MetS than in women without MetS (P <0.05). HSP60, anti-HSP70, and CRP concentrations increased with the number of features indicative of MetS (P < 0.05). There was a significant positive correlation between anti-HSP70 and WC, blood pressure and HOMA-IR, and between CRP and WC, blood pressure, glucose, HOMA-IR, and triglycerides (P <0.05). In postmenopausal women, serum HSP60 and anti-HSP70 concentrations increased with accumulating features of the metabolic syndrome. These results suggest a greater immune activation that is associated with cardiovascular risk in postmenopausal women with metabolic syndrome.

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Relationship of C-reactive protein with components of the metabolic syndrome in a Tunisian population

Cited by 19 publications

References 47 publications

Leptin, Insulin and Lipid Profiles in Obese Subjects with and without Metabolic Syndrome in the Region of Cap-Bon: Tunisia

Leptin, Insulin and Lipid Profiles in Obese Subjects with and without Metabolic Syndrome in the Region of Cap-Bon: Tunisia

Moroccan Obese Patients with or without Metabolic Syndrome: Dietary Pattern and Risk of Cardiovascular Disease

The 60- and 70-kDa heat-shock proteins and their correlation with cardiovascular risk factors in postmenopausal women with metabolic syndrome

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