Relationship of Calcium, Magnesium, Zinc and CopperConcentrations in the Arterial Wall and Serum in Atherosclerosis Obliterans and Aneurysm

Iskra, Maria; Patelski, J; Majewski, Wacław

doi:10.1016/s0946-672x(97)80020-x

Cited by 35 publications

(18 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Notably, atheromatous plaques and surrounding tissues are reportedly enriched in copper content [254,255] with a preferential metal accumulation in the nuclei [256]. Moreover, increased serum copper levels have been reported in atherosclerotic subjects with respect to healthy subjects (20-25 vs. 17-20 μ M ) [255,257]. …”

Section: Copper and Angiogenic Diseasesmentioning

confidence: 99%

Behind the Link between Copper and Angiogenesis: Established Mechanisms and an Overview on the Role of Vascular Copper Transport Systems

Urso

Maffia²

2015

J Vasc Res

129

View full text Add to dashboard Cite

Angiogenesis critically sustains the progression of both physiological and pathological processes. Copper behaves as an obligatory co-factor throughout the angiogenic signalling cascades, so much so that a deficiency causes neovascularization to abate. Moreover, the progress of several angiogenic pathologies (e.g. diabetes, cardiac hypertrophy and ischaemia) can be tracked by measuring serum copper levels, which are being increasingly investigated as a useful prognostic marker. Accordingly, the therapeutic modulation of body copper has been proven effective in rescuing the pathological angiogenic dysfunctions underlying several disease states. Vascular copper transport systems profoundly influence the activation and execution of angiogenesis, acting as multi-functional regulators of apparently discrete pro-angiogenic pathways. This review concerns the complex relationship among copper-dependent angiogenic factors, copper transporters and common pathological conditions, with an unusual accent on the multi-faceted involvement of the proteins handling vascular copper. Functions regulated by the major copper transport proteins (CTR1 importer, ATP7A efflux pump and metallo-chaperones) include the modulation of endothelial migration and vascular superoxide, known to activate angiogenesis within a narrow concentration range. The potential contribution of prion protein, a controversial regulator of copper homeostasis, is discussed, even though its angiogenic involvement seems to be mainly associated with the modulation of endothelial motility and permeability.

show abstract

Section: Copper and Angiogenic Diseasesmentioning

confidence: 99%

Behind the Link between Copper and Angiogenesis: Established Mechanisms and an Overview on the Role of Vascular Copper Transport Systems

Urso

Maffia²

2015

J Vasc Res

129

View full text Add to dashboard Cite

show abstract

“…In subjects greater than 75 years of age, there are increases in serum Cu and decreases in Zn [28]. This is consistent with the bulk of the literature that reports that aging is characterized by elevated plasma Cu levels [29][30][31][32][33][34] and decreased plasma Zn concentrations [29,[35][36][37][38][39]. These changes may be associated with concomitant alterations in the levels of metal ions within the human brain, possibly reflected in an age-related increase in ceruloplasmin in the superior temporal gyrus of normal individuals [40].…”

Section: Aging and Metalssupporting

confidence: 84%

Metal Complexing Agents for the Treatment of Alzheimer's Disease

White

Bush

Topics in Medicinal Chemistry

View full text Add to dashboard Cite

“…Comparison of the concentration of trace elements of blood serum and arterial wall in the studied groups as well as in different parts of the arterial wall in the AO groups indicates the dislocation of those elements from serum to the wall and accumulation in its inner layer (intima) and atherosclerosis plaque in case of it forming [26]. …”

Section: Resultsmentioning

confidence: 99%

Application of spectroscopic techniques: ICP-OES, LA-ICP-MS and chemometric methods for studying the relationships between trace elements in clinical samples from patients with atherosclerosis obliterans

et al. 2011

Self Cite

View full text Add to dashboard Cite

The study was aimed to evaluate the influence of the vascular disease, atherosclerotic obliterans (AO), on the location and concentration of elements in the arterial wall and serum. Use of a modern method for studying element’s concentration and distribution in samples of clinical material, i.e. laser ablation inductively coupled plasma mass spectrometry, is presented. Elements are not equally distributed between the inner (intima) and the outer (media + adventitia) layer of the arterial wall. Among the studied elements, calcium was found to have an unquestionable role in the calcification of the wall. Increased concentration of calcium found in the inner part of the atherosclerotic arterial wall and in the plaque, as compared to the control arterial wall samples, demonstrates the unquestionable role of this element in the calcification of the wall observed in AO. Applied chemometric methods were useful for demonstrating the differences in the element’s concentration in blood serum and the arterial wall samples between AO and the control group.FigureImage of the ruptured atherosclerotic plaque done while surgery

show abstract

Relationship of Calcium, Magnesium, Zinc and CopperConcentrations in the Arterial Wall and Serum in Atherosclerosis Obliterans and Aneurysm

Cited by 35 publications

References 13 publications

Behind the Link between Copper and Angiogenesis: Established Mechanisms and an Overview on the Role of Vascular Copper Transport Systems

Behind the Link between Copper and Angiogenesis: Established Mechanisms and an Overview on the Role of Vascular Copper Transport Systems

Metal Complexing Agents for the Treatment of Alzheimer's Disease

Application of spectroscopic techniques: ICP-OES, LA-ICP-MS and chemometric methods for studying the relationships between trace elements in clinical samples from patients with atherosclerosis obliterans

Contact Info

Product

Resources

About