Relationship of carotenoid and vitamins A and E with the acute inflammatory response in acute pancreatitis

Curran, Finlay; Sattar, Naveed; Talwar, Dinesh; Baxter, J. N.; Imrie, C. W.

doi:10.1046/j.1365-2168.2000.01375.x

Cited by 66 publications

(44 citation statements)

References 22 publications

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“…Among patients with type II diabetes mellitus, vitamin E supplementation of 800 U/day resulted in decreases of C-reactive protein concentrations (Upritchard et al, 2000). Inverse relations between C-reactive protein concentrations and concentrations of retinol, vitamin C, tocopherol, and lutein have been noted among patients with lung cancer and acute pancreatitis (Curran et al, 2000) and among those undergoing orthopedic surgery (Louw et al, 1992). Furthermore, vitamins A, C, and E decrease transiently during the course of an acute myocardial infarction (Labadarios et al, 1987).…”

Section: Discussionmentioning

confidence: 99%

“…However, little is known about how nutritional status is associated with concentrations of inflammatory markers. A number of studies, which generally included either small numbers of participants or were conducted in special populations, have described inverse relationships between C-reactive protein concentration and circulating concentrations of antioxidants (Labadarios et al, 1987;Louw et al, 1992;Boosalis et al, 1996;Sattar et al, 1997;Talwar et al, 1997;Root et al, 1999;Curran et al, 2000;McMillan et al, 2000;Upritchard et al, 2000). In addition, inverse associations were shown between C-reactive protein concentration and concentrations of carotenoids and serum retinol using NHANES III data (Kritchevsky et al, 2000;Stephensen & Gildengorin, 2000;Erlinger et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

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C-reactive protein concentration and concentrations of blood vitamins, carotenoids, and selenium among United States adults

et al. 2003

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Objective: To examine the relationships between circulating concentrations of C-reactive protein and concentrations of retinol, retinyl esters, vitamin C, vitamin E, carotenoids, and selenium. Design: Cross-sectional study using National Health and Nutrition Examination Survey III (1988 data. Setting: United States population. Subjects: Up to 14 519 US noninstitutionalized civilian men and women aged Z20 y. Results: C-reactive protein concentration (dichotomized at the sex-specific 85th percentile) was inversely and significantly associated with concentrations of retinol, retinyl esters, vitamin C, a-carotene, b-carotene, cryptoxanthin, lutein/zeaxanthin, lycopene, and selenium after adjustment for age, sex, race or ethnicity, education, cotinine concentration, body mass index, leisure-time physical activity, and aspirin use. Conclusions: These results suggest that the inflammatory process, through the production of reactive oxygen species, may deplete stores of antioxidants. Whether increased consumption of foods rich in antioxidants or supplementation with antioxidants can provide health benefits to people characterized by elevated C-reactive protein concentrations may be worthy of further study.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

C-reactive protein concentration and concentrations of blood vitamins, carotenoids, and selenium among United States adults

et al. 2003

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“…Additionally, given the characteristics of the sample, it is possible that the observed inverse association of serum b-carotene with AL was heavily influenced by its known strong association with obesity (38,42) and CRP (39,43) . Previous studies suggest that the inflammatory environment (58)(59)(60)70,71) and obesity-linked oxidation of the lipoprotein carriers of b-carotene, specifically LDL (72,73) , may be related to low serum b-carotene levels.…”

Section: Discussionmentioning

confidence: 99%

Relationship of serum carotenoid concentrations with allostatic load as a measure of chronic stress among middle-aged adults in the USA

Rosenberg

Park

Eldeirawi

2014

Public Health Nutr.

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Objective: Chronic stress and repeated physiological attempts at stress adaptation may result in 'fatigue' and suboptimal performance of multiple physiological systems, i.e. allostatic load (AL). Although carotenoids have been linked with individual cardiovascular, metabolic and inflammatory biomarkers, little is known about the relationship of carotenoids with the multi-system biomarker measure of stress, AL. The present study examined the association of serum concentrations of carotenoids with AL among middle-aged adults. Design: Cross-sectional. AL score was calculated based on nine risk-rated indicators (systolic and diastolic blood pressure, pulse rate, total and HDL-cholesterol, glycosylated Hb, sex-specific waist-to-hip ratio, albumin and C-reactive protein). Subjects: Middle-aged (45-64 years, n 3387) men and women participants in the Third National Health and Nutrition Examination Survey, NHANES III (1988-1994. Results: Serum b-carotene concentration was inversely associated with high AL after adjusting for age, education, race/ethnicity, serum cotinine, alcohol consumption, physical activity and other carotenoids (a-carotene, b-cryptoxanthin, lycopene, lutein/zeaxanthin). Females in the lowest b-carotene quartile were 2?94 (95 % CI 1?74, 4?94) times and males 2?90 (95 % CI 1?43, 5?89) times as likely to have high AL, compared with peers in the highest quartile (P for linear trend 0?001 and 0?018 for females and males, respectively). Mean serum b-carotene concentrations were also inversely associated with the number of 'high-risk' AL components (P for linear trend ,0?001 and 0?004 for females and males, respectively). Conclusions: Our study adds to evidence linking low b-carotene levels with unfavourable health outcomes.

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“…Oxidative stress is one of the main processes during acute pancreatitis 28 and the higher concentrations of reactive oxygen species in the hypothermic group suggest that it plays a role in the pathophysiology of the damage process in induced AP. How hypothermia increases the oxidative stress is still an open question.…”

Section: Discussionmentioning

confidence: 99%

“…15,16 The ischemia and reperfusion injury has been also treated with hypothermia, and many authors have found an amelioration of the lesions in experimental studies. [17][18][19][20][21] Several studies have suggested that oxygen radicals play a role in a very early phase of AP, [22][23][24][25][26][27][28] and that the elevation of the pancreas oxidative status is related to the severity of the disease. 26,27 Exacerbated production of free oxygen radicals is related to the alteration of blood flow and to the ischemia/reperfusion phenomena.…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress Is Enhanced by Hypothermia Imposed on Cerulein-Induced Pancreatitis in Rats

Andraus

Jukemura

Dutra

et al. 2007

Clinics

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MC. Oxidative stress is enhanced by hypothermia imposed on cerulein-induced pancreatitis in rats. Clinics. 2007;62(4): 483-90. BACKGROUND:Hypothermia is a frequent event in severe acute pancreatitis (AP) and its real effects on the normal pancreas have not been well demonstrated. Moreover, neither have its effects on the outcome of acute pancreatitis been fully investigated. One hypothesis is that oxidative stress may be implicated in lesions caused or treated by hypothermia. Aim of the study: To investigate the effect of hypothermia in cerulein-induced acute pancreatitis (CIAP) in rats and the role played by oxidative stress in this process. METHODS: Male Wistar rats were divided into hypothermic and normothermic groups. Hypothermia was induced with a cold mattress and rectal temperature was kept at 30 o C for one hour. Acute pancreatitis was induced with 2 doses of cerulein (20 ìg/kg) administered at a one-hour interval. Serum amylase, pancreas vascular permeability by Evan's blue method, pancreas wet-to-dry weight ratio and histopathology were analyzed in each group. RESULTS: When compared with normothermic rats, hypothermic animals, with cerulein-induced acute pancreatitis, showed higher levels of pancreatic vascular permeability (P < 0.05), pancreas wet-to-dry weight ratio (P = 0.03), and histologically verified edema (P < 0.05), but similar serum amylase levels. The hypothermic group showed a higher oxidized-reduced glutathione ratio than the normothermic group. CONCLUSION: Moderate hypothermia produced a greater inflammatory response in established acute pancreatitis induced by cerulein in rats. Moreover, this study suggests that oxidative stress may be one of the mechanisms responsible for the worse outcome in hypothermic rats with cerulein-induced acute pancreatitis.

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Relationship of carotenoid and vitamins A and E with the acute inflammatory response in acute pancreatitis

Abstract: In acute pancreatitis, circulating concentrations of vitamin antioxidants are reduced and are inversely related to the rise in CRP level.

Cited by 66 publications

References 22 publications

C-reactive protein concentration and concentrations of blood vitamins, carotenoids, and selenium among United States adults

C-reactive protein concentration and concentrations of blood vitamins, carotenoids, and selenium among United States adults

Relationship of serum carotenoid concentrations with allostatic load as a measure of chronic stress among middle-aged adults in the USA

Oxidative Stress Is Enhanced by Hypothermia Imposed on Cerulein-Induced Pancreatitis in Rats

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