Relationship of chest computed tomography score with disease severity and laboratory values in children with <scp>COVID</scp>‐19

Çetin, Ceren; Karaaslan, Ayşe; Akın, Yasemin; Arifoğlu, Meral; Rona, Günay; Demirhan, Recep

doi:10.1111/jpc.15839

Cited by 7 publications

(4 citation statements)

References 22 publications

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“…Another metaanalysis by Nino et al also reported ground glass opacity as the most common pattern in children, which aligns with our study [38]. Consistent with our study, an abnormal chest CT scan in a study conducted in Istanbul showed a statistically signifcant relationship with the severity of the disease of COVID-19, which was associated with a relative increase in the risk of mortality [39].…”

Section: Dyspnea and Low Oxygen Saturation Raised The Risk Of Death A...supporting

confidence: 92%

Which Groups of Children Are at More Risk of Fatality during COVID-19 Pandemic? A Case-Control Study in Yazd, Iran

Shafaei,

Nafei,

Karimi

et al. 2023

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Introduction. The study aims to investigate the characteristics, comorbidities, laboratory findings, and clinical manifestations of under 18-year-old patients who died with the diagnosis of COVID-19 and determination of the most prevalent risk factors. Method. This case-control study was performed at a referral hospital in Yazd from March 2020 to August 2021. All patients under 18 years who were diagnosed through real-time RT-PCR, chest computed tomography, and the World Health Organization definition were divided into deceased and survived groups. The characteristics (age and sex), disease severity, comorbidities, laboratory findings, and clinical manifestations of the two groups were compared and analyzed using SPSS, version 18 (SPSS Inc., Chicago, III., USA). Results. A total of 24 patients in the deceased group and 167 patients in the survived group were compared. The highest mortality rate was observed in the age group of 1 month to 5 years, although no statistically significant relationship was found between age groups and the risk of mortality. Disease severity, dyspnea, low oxygen saturation on admission, length of hospital stays, and hospitalization history before the last admission were significantly correlated with mortality ( P < 0.05). Lymphopenia increased the probability of mortality by more than two times (OR: 2.568; 95% CI (0.962–6.852)), but this was not the case for D-dimer and C-reactive protein. Furthermore, 27.5% of survived patients had normal chest CT scans, which was a statistically significant difference compared to the deceased patients ( P : 0.031). Conclusion. Based on the findings of this study, dyspnea, low oxygen saturation, and lymphopenia are critical indicators for identifying high-risk children with COVID-19 and triaging them for better care and treatment.

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Section: Dyspnea and Low Oxygen Saturation Raised The Risk Of Death A...supporting

confidence: 92%

Which Groups of Children Are at More Risk of Fatality during COVID-19 Pandemic? A Case-Control Study in Yazd, Iran

Shafaei,

Nafei,

Karimi

et al. 2023

Canadian Journal of Infectious Diseases and Medical Microbiolog

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“…Thus, it has been demonstrated that in children with mild forms of SARS-CoV-2 infection, a higher ultrasound score persists than in children who have not had this infection, unlike children who have had an asymptomatic form, have the same ultrasound score as the children who have not contracted SARS-CoV-2 infection [15]. Some studies report correlations between the tomographic image of the lung in SARS-CoV-2 infection and the elevated alanine aminotransferase, D-dimer and leukocyte values [18].…”

mentioning

confidence: 99%

COVID-19 in Infants and Children under 2 Years—Could Lung Ultrasound Score Be Correlated with Biomarkers and Symptoms?

Stoicescu,

Lovrenski,

Iacob

et al. 2023

Biomedicines

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Introduction: It is already well known that infants and children infected with COVID-19 develop mild to moderate forms of the disease, with fever and oropharyngeal congestion being the most common symptoms. However, there are instances when patients claim to be experiencing respiratory symptoms. Because of the repeated lung examinations required in these situations, non-irradiating imaging techniques are preferred. This study’s objective is to ascertain the value of lung ultrasonography (LUS) in the medical management of these specific cases. Methods: Infants and children under two years old with SARS-CoV-2 infection were evaluated using LUS. Patients with other respiratory pathologies were excluded by using specific tests. The LUS score (LUSS) was correlated with biomarkers and clinical findings using the Mann–Whitney U test and Spearman’s rank correlation rho. Results: The LUSS for each patient varied from 1 to 8 points out of a maximum of 36 points. The arithmetic mean was 4.47 ± 2.36 (S.D), while the 95% CI for the arithmetic mean was 3.33 to 5.61. Sparse B-lines were present in all enrolled infants and children (100%), while only 36.84% developed alveolar syndrome (confluent B-lines). The lung changes were correlated with their biomarkers, specifically inflammatory markers. The correlation between LUSS and LDH, D-dimers, and IL-6 was a strongly positive one with rho = 0.55 (p = 0.001, 95% CI 0.13 to 0.80) between the LUSS and D-dimer levels and rho = 0.60 (p = 0.03, 95% CI 0.04 to 0.87) between LUSS and D-dimer levels at symptomatic infants and children (with respiratory involvement). Conclusions: Infants and children under the age of two are prone to develop mild forms of COVID-19 disease with a B-line pattern on LUS, although inflammatory markers have elevated blood levels. Despite the small sample, D-dimer levels and O2 saturation were correlated with LUSS in patients with respiratory involvement, while similar results were also found in the entire lot.

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“…It has been documented that not the entirety of children with COVID-19 has chest CT alterations [5].…”

mentioning

confidence: 99%

“…Moreover, because a significant association between chest CT COVID-19 severity and laboratory results has been observed, CT has been suggested as a tool for assessing the severity of the disease [5].…”

mentioning

confidence: 99%

Potentials of post-mortem CT (PMCT) in paediatric cases related to SARS-CoV-2 infection

Filograna

Manenti

O’Donnell

et al. 2023

Forensic Sci Med Pathol

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We read the paper by Khairwa and Jat [1] with great interest. The authors demonstrated that the lungs are predominantly affected by COVID-19, with diffuse alveolar damage (DAD) as the most frequent histological pattern (78.3%), likewise to adults.To this regard, we would like to discuss the promising role of post-mortem computed tomography (PMCT) in paediatric deaths related to SARS-CoV-2 infection.Recently, post-mortem imaging has been proposed as a useful investigative method alongside classical, invasive autopsy, particularly in paediatrics, because of ethical and religious reasons [2,3].PMCT studies on paediatric deaths related to SARS-CoV-2 infections have never been reported in the literature. Conversely, the value of PMCT in the study of adult cadavers with SARS-CoV-2 infection has been well acknowledged [4].The literature on PMCT imaging in adults with SARS-CoV-2 showed that the lungs are the most affected organ. The most common findings are bilateral, mixed pattern of ground glass opacities, and/or consolidations, in a diffuse or a peripheral distribution [4], the most severe cases with prevalence of diffuse consolidations, resembling the histopathological pathway of severe DAD [4].PMCT in adult SARS-CoV-2-positive cases has been pro-

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Relationship of chest computed tomography score with disease severity and laboratory values in children with COVID‐19

Cited by 7 publications

References 22 publications

Which Groups of Children Are at More Risk of Fatality during COVID-19 Pandemic? A Case-Control Study in Yazd, Iran

Which Groups of Children Are at More Risk of Fatality during COVID-19 Pandemic? A Case-Control Study in Yazd, Iran

COVID-19 in Infants and Children under 2 Years—Could Lung Ultrasound Score Be Correlated with Biomarkers and Symptoms?

Potentials of post-mortem CT (PMCT) in paediatric cases related to SARS-CoV-2 infection

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