Relationship of childhood adversity and neighborhood violence to a proinflammatory phenotype in emerging adult African American men: An epigenetic link

Janusek, Linda Witek; Tell, Dina; Gaylord‐Harden, Noni K.; Mathews, Herbert L.

doi:10.1016/j.bbi.2016.10.006

Cited by 110 publications

(99 citation statements)

References 79 publications

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“…Coincidently, these two inflammatory indicators were elevated in different types of life stress. For instance, severe levels of childhood abuse were associated with a more elevated acute stress-induced IL-6 response, possibly due to reduced methylation of the IL-6 promoter (Janusek et al, 2017). Adults who had greater childhood adversity was reported to have more depressive symptoms and elevated concentrations of CRP (Janusek et al, 2017).…”

Section: Stress Inflammation and Diseasesmentioning

confidence: 99%

“…For instance, severe levels of childhood abuse were associated with a more elevated acute stress-induced IL-6 response, possibly due to reduced methylation of the IL-6 promoter (Janusek et al, 2017). Adults who had greater childhood adversity was reported to have more depressive symptoms and elevated concentrations of CRP (Janusek et al, 2017). Recent studies have suggested that CRP and IL-6 are mechanisms by which early adversity may contribute to CVD (Ridker et al, 2002; Albert et al, 2006; Graham et al, 2006).…”

Section: Stress Inflammation and Diseasesmentioning

confidence: 99%

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Inflammation: The Common Pathway of Stress-Related Diseases

Liu

Wang

Jiang

2017

Front. Hum. Neurosci.

566

333

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While modernization has dramatically increased lifespan, it has also witnessed that the nature of stress has changed dramatically. Chronic stress result failures of homeostasis thus lead to various diseases such as atherosclerosis, non-alcoholic fatty liver disease (NAFLD) and depression. However, while 75%–90% of human diseases is related to the activation of stress system, the common pathways between stress exposure and pathophysiological processes underlying disease is still debatable. Chronic inflammation is an essential component of chronic diseases. Additionally, accumulating evidence suggested that excessive inflammation plays critical roles in the pathophysiology of the stress-related diseases, yet the basis for this connection is not fully understood. Here we discuss the role of inflammation in stress-induced diseases and suggest a common pathway for stress-related diseases that is based on chronic mild inflammation. This framework highlights the fundamental impact of inflammation mechanisms and provides a new perspective on the prevention and treatment of stress-related diseases.

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Section: Stress Inflammation and Diseasesmentioning

confidence: 99%

Section: Stress Inflammation and Diseasesmentioning

confidence: 99%

Inflammation: The Common Pathway of Stress-Related Diseases

Liu

Wang

Jiang

2017

Front. Hum. Neurosci.

566

333

View full text Add to dashboard Cite

show abstract

“…Furthermore, evidence suggests that childhood adversity, particularly severe physical and sexual abuse, confers risk for cardiovascular events, particularly among women (Garad et al 2017). Similarly, among adults with greater childhood adversity/trauma, elevated risk for depressive symptoms, higher serum CRP, reduced methylation of the IL-6 promoter, and higher serum IL-6 have been observed (Janusek et al 2017). These results shed light on potential epigenetic mechanisms that could link childhood adversity to disproportionally elevated risks of inflammatory disease in adulthood.…”

Section: Stress and Cardiovascular Diseasementioning

confidence: 99%

The Impact of Everyday Stressors on the Immune System and Health

Seiler

Fagundes

Christian

2019

Stress Challenges and Immunity in Space

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“…To our knowledge, only a handful of studies to date have examined this. In these studies, early adversity, depressive symptoms, and clinical depression were related to heightened inflammatory reactivity to an acute stressor among healthy adults (Carpenter et al, 2010; Fagundes et al, 2013; Janusek et al, 2017; Pace et al, 2006). The dearth of studies focusing on inflammatory reactivity to psychosocial threat is particularly surprising in light of past theoretical work suggesting that early adversity and depression may increase biological and psychological sensitivity to stress, and that repeated exaggerated inflammatory reactivity to stress over time contributes to low-grade chronic inflammation and increases risk for poor health-related outcomes (Brydon and Steptoe, 2005; Chiang et al, 2015b; Danese and Lewis, 2017; Fagundes and Way, 2014; McEwen and Seeman, 1999; Nusslock and Miller, 2016; O’Hara et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Adiposity moderates links from early adversity and depressive symptoms to inflammatory reactivity to acute stress during late adolescence

Chiang

Bower

Irwin

et al. 2017

Brain, Behavior, and Immunity

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Both early adversity and depression are associated with heightened inflammation. However, few studies have focused on inflammatory reactivity to psychosocial stress and examined adiposity as a potential moderator. Yet, repeated heightened inflammatory reactivity over time is thought to contribute to low-grade chronic inflammation and adipose tissue is a key source of pro-inflammatory cytokines. The purpose of the present study was to examine whether early adversity and depressive symptoms were related to stress-induced inflammation and whether these associations varied by total body and abdominal adiposity as measured by body mass index (BMI) and waist circumference (WC) in a sample of late adolescents. Participants reported on their early family environment and current depressive symptoms, had their height, weight, and WC assessed for adiposity markers, and provided blood samples for IL-6 assessment before and after a standardized laboratory stress task. No main effect of early adversity on IL-6 reactivity to acute stress was observed. However, significant interactions between early adversity and BMI and WC emerged. Greater exposure to early adversity was associated with greater IL-6 responses only among adolescents with higher BMI or WC. The same pattern of findings was observed for depressive symptoms. Additionally, moderated mediation analyses indicated that among adolescents with greater adiposity, early adversity indirectly influenced IL-6 reactivity via current depressive symptoms. These findings contribute to our understanding of vulnerability factors that may amplify the associations between early adversity and depressive symptoms and inflammation during relatively early stages of life.

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Relationship of childhood adversity and neighborhood violence to a proinflammatory phenotype in emerging adult African American men: An epigenetic link

Cited by 110 publications

References 79 publications

Inflammation: The Common Pathway of Stress-Related Diseases

Inflammation: The Common Pathway of Stress-Related Diseases

The Impact of Everyday Stressors on the Immune System and Health

Adiposity moderates links from early adversity and depressive symptoms to inflammatory reactivity to acute stress during late adolescence

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