Relationship of cigarette smoking and snuff dipping to plasma fibrinogen, fibrinolytic variables and serum insulin. The Northern Sweden MONICA study

Eliasson, Mats; Asplund, Kjell; Evrin, Per-Eric; Lundblad, Dan

doi:10.1016/0021-9150(94)05425-i

Cited by 129 publications

(118 citation statements)

References 37 publications

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“…The reasons are unclear, but some degree of selection bias towards ablative treatment may exist, as smoking has been seen as a poor prognostic factor among endocrinologists. Smoking status at the time of diagnosis cannot be verified but we have shown in a study from the same area that self-reported tobacco habits, both among smokers and ex-smokers, were highly reliable when validated by plasma nicotine and cotinine (28). The effect of smoking on TAO is dosedependent (29) and the mean numbers of cigarettes smoked in Sweden has declined for many years.…”

Section: Discussionmentioning

confidence: 91%

“…The effect of smoking on TAO is dosedependent (29) and the mean numbers of cigarettes smoked in Sweden has declined for many years. In 2010, the average Swedish smoker now smokes only ten cigarettes per day compared with the average in Europe (14) and in Southern Europe (28). Thus a lack of relationship between smoking and TAO may be due to the low exposure in Swedes.…”

Section: Discussionmentioning

confidence: 99%

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Long-term prognosis after medical treatment of Graves' disease in a northern Swedish population 2000–2010

Mohlin

Nyström

Eliasson

2014

European Journal of Endocrinology

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Objective: To investigate the long-term prognosis of patients with Graves' disease (GD) after antithyroid drug (ATD) treatment and follow-up outside of highly specialised care. Design and methods: Medical records of all patients diagnosed with first-time GD in 2000-2010 with at least 6 months ATD treatment at a central hospital and follow-up in primary health care in the county of Norrbotten in northern Sweden were retrospectively reviewed. Patients were followed for relapse until 31st December 2012. We included 219 patients (mean age 46 years, 82.5% women) with follow-up of maximum 10 years and 829 observed patient years. Data were analysed using Kaplan-Meier estimates and log-rank test. Results: During the observation period, 43.5% of the patients had relapsed into active GD. The cumulative relapse rates were 22.6, 30.2, 36.9 and 41.5% after 6 months, 1, 3 and 5 years respectively. The presence of goitre (PZ0.014) predicted relapse. Previous smoking was protective against relapse (PZ0.003). The levels of free thyroxine or free tri-iodothyronine, age, gender, current smoking and ophthalmopathy did not predict relapse. Agranulocytosis was found in 1.7% (95% CI 0.7-4.0%). Conclusion: A long-term remission of 56.5%, in an iodine-sufficient area where ATD is offered to most patients in the real world of central and district hospitals, is higher than in most studies. Relapse was most common during the first year, and prognosis was excellent after 4 years without relapse. The protective effect of previous smoking merits further research.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Long-term prognosis after medical treatment of Graves' disease in a northern Swedish population 2000–2010

Mohlin

Nyström

Eliasson

2014

European Journal of Endocrinology

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“…Since the levels of the selected markers are increased in smokers (Eliasson et al, 1995;de Maat et al, 1996, Miller et al, 1998Margaglione et al, 1998), we hypothesized that reduction of the oxidative stress by tea polyphenols may normalize the increased levels.…”

Section: Introductionmentioning

confidence: 97%

Consumption of black and green tea has no effect on inflammation, haemostasis and endothelial markers in smoking healthy individuals

Maat¹,

Pijl

Kluft³

et al. 2000

Eur J Clin Nutr

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Obejective: Firstly, to study the effect of tea and tea polyphenols on cardiovascular risk indicators of the in¯ammatory system (IL6, IL1b and TNF-a, CRP), and on haemostasis and endothelial proteins with an acute phase behaviour (®brinogen, vWF, PAI-1, FVIIa and u-PA). Secondly, to study the relationship between plasma levels of antioxidants (a-tocopherol, b-carotene and vitamin C) and these acute-phase, cardiovascular risk indicators. Design: Randomized study. Subjects: Sixty-four smoking healthy volunteers were recruited by newspaper advertisements; there were ®ve dropouts. Intervention: Four-week administration of black tea, green tea, green tea polyphenol isolate and mineral water (13 ± 16 per group). Measures: Plasma levels of the in¯ammatory markers IL6, IL1b, TNF-a, CRP, ®brinogen, vWF, PAI-1, FVIIa and u-PA and of the antioxidants a-tocopherol, b-carotene and vitamin C. Results: Different dosages of tea polyphenols had no effect on in¯ammation, haemostasis and endothelial markers. There was a signi®cant negative correlation between the levels of the antioxidant b-carotene and the in¯ammation markers IL6 and ®brinogen (r 70.35 and r 70.37, respectively, P`0.01) in this group of smokers. Remarkably, there was a signi®cant positive correlation between the levels of the antioxidant atocopherol and the in¯ammation marker IL6 (r 0.28, P`0.05). Conclusions: Tea drinking had no effect on the levels of the in¯ammation, haemostasis and endothelial cardiovascular risk factors measured. We did observe a relationship between the antioxidant variables atocopherol and b-carotene and in¯ammation markers in this group of healthy smoking subjects. Sponsorship: This work was supported in part by

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“…it suggested an action of both risk factors on similar aspects of the pathogenic process (5,8). Some evidence implicates smoking directly in the pathogenesis of thromboembolic states in the less platelet-dependent venous side of circulation (6,14). Potential procoagulant mechanisms that might be associated with smoking are: increased fibrinogen level from increased interleukin-6, increased catecholamine release, increased tissue factor level, impaired fibrinolysis, impaired platelet activation (3,6,18).…”

Section: Resultsmentioning

confidence: 99%

Impact of Oral Contraceptives and Smoking on Arterial and Deep Venous Thrombosis: A Retrospective Case-Control Study

Петров

2010

Biotechnology & Biotechnological Equipment

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Relationship of cigarette smoking and snuff dipping to plasma fibrinogen, fibrinolytic variables and serum insulin. The Northern Sweden MONICA study

Cited by 129 publications

References 37 publications

Long-term prognosis after medical treatment of Graves' disease in a northern Swedish population 2000–2010

Long-term prognosis after medical treatment of Graves' disease in a northern Swedish population 2000–2010

Consumption of black and green tea has no effect on inflammation, haemostasis and endothelial markers in smoking healthy individuals

Impact of Oral Contraceptives and Smoking on Arterial and Deep Venous Thrombosis: A Retrospective Case-Control Study

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