Relationship of Early Vitamin D Concentrations and Gestational Diabetes Mellitus in Indian Pregnant Women

Dwarkanath, Pratibha; Vinotha, Ponnusamy; Thomas, Tinku; Joseph, Siji; Thomas, Annie; Shirley, George; Sheela, C. N.; Mehta, Saurabh; Kurpad, Anura V

doi:10.3389/fnut.2019.00116

Cited by 20 publications

(24 citation statements)

References 42 publications

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“…This is in line with findings of a recent large case‐control study among a cohort (116 GDM cases and 303 controls) of pregnant women in neighboring Saudi Arabia, which reported that women with vitamin D deficiency in early pregnancy had a 2.87 higher risk of subsequent GDM 11 . As mentioned above, several studies showed a significant association between GDM and vitamin D deficiency/vitamin D level 7–11 . Moreover, a recent meta‐analysis of 20 studies including 9209 participants reported that pregnant women who had vitamin D deficiency had a significantly increased risk for GDM 19 .…”

Section: Discussionsupporting

confidence: 88%

“…Published evidence on the relationship between vitamin D level and the occurrence of GDM is not yet conclusive. Many studies have shown a significant association between GDM and vitamin D level, 7–11 but other studies have shown no significant difference in this level between women with GDM and a control group of women 12–15 . Moreover, there are no published data on the association between vitamin D levels and GDM in Africa (including Sudan).…”

Section: Introductionmentioning

confidence: 99%

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Maternal early pregnancy serum level of 25‐Hydroxyvitamin D and risk of gestational diabetes mellitus

Al-Shafei

Rayis

Mohieldein

et al. 2020

Intl J Gynecology & Obste

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Objective To assess if early pregnancy (≤14 weeks of gestation) 25‐hydroxyvitamin D (25(OH)D) level is associated with risk of gestational diabetes mellitus (GDM). Methods A nested case‐control study (60 women in each arm) was conducted at Saad Abualila Hospital (Khartoum, Sudan) during the period of January to November 2017. Clinical and obstetrical data were gathered, 25(OH)D concentration was measured at the first prenatal visit, and a 75‐g oral glucose tolerance test was performed at 24–28 weeks of gestation. Results Compared with women without GDM, in women with GDM, the median of the 25(OH)D level was significantly lower (7.3 [interquartile range 5.7–8.8] ng/mL versus 8.4 [interquartile range 6.6–11.9] ng/mL, P=0.001). All women in the study (with and without GDM) had vitamin D deficiency (25(OH)D<20 ng/mL). The results of the logistic regression showed that a low 25(OH)D level was the only factor associated with GDM (odds ratio [OR] 0.83, 95% confidence interval [CI] 0.73–0.95, P=0.010). Women with 25(OH)D less than 6.0 ng/mL were at a higher risk of GDM (OR 3.2, 95% CI 1.29–8.12, P=0.012). Conclusion A low 25(OH)D level in early pregnancy was associated with increased risk of GDM. This finding might be useful in predicting GDM.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Maternal early pregnancy serum level of 25‐Hydroxyvitamin D and risk of gestational diabetes mellitus

Al-Shafei

Rayis

Mohieldein

et al. 2020

Intl J Gynecology & Obste

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“…Our ndings are similar to some previous studies that investigated vitamin D status and the GDM risk [20][21][22][23], and the nding from three separate meta-analyses of published studies [24][25][26], which reported 38-61% higher risk of GDM among women with vitamin D deciency [18,19,26]. Recently, Pratibha Dwarkanath et al have reported that lower vitamin D concentrations in early pregnancy may be associated with a higher risk of developing GDM [21]. Furthermore, a study conducted in Saudi Arabia has concluded the development of GDM among pregnant women having decient vitamin D status [22].…”

Section: Discussionsupporting

confidence: 91%

Early Pregnancy Maternal Vitamin D Deficiency and Risk of Gestational Diabetes Mellitus in Libyan Pregnant Women

Getlawi¹,

Hawda³

et al. 2020

IJAR

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Background Vitamin D deficiency is a common occurrence, which affects maternal health during pregnancy. Evidence is accumulating for a role of a low level of vitamin D during the early pregnancy as a risk factor for the development of gestational diabetes mellitus (GDM). Our objectives are to describe the patterns of vitamin D levels in early pregnancy in mothers attending main antenatal services in Ajdabiya city, during the first quarter of the year 2017 and to examine the relationship between vitamin D levels and glucose metabolic derangements in pregnant women among the above-described population. Methods A cohort study was conducted in healthy pregnant women attending routine antenatal care in Ajdabiya city in 2017. All mothers were screened for serum 25 (OH) D level and glycated hemoglobin (HbA1c) and anthropometric by the time of booking during the first trimester (gestational age "GA" 7-15th week of pregnancy). All women with low 25 (OH) D level were screened for GDM with non-fasting post-challenge blood glucose and confirmed by OGTT according to the American Diabetes Association (ADA) classification of GDM criteria in their 2nd trimester. Data was analyzed by using SPSS, IBM 20.0. Results All mothers in the study population were Libyan, their ages ranged from 18-43 years. Parity ranged from nulliparous to P10. More than 60% of mothers were housewives while others were either working or students and considered as having an outdoor lifestyle. In the first trimester, we detected 412 mothers had serum vitamin D3 below normal, the majority of cases had deficient serum 25 (OH) D (391, 94.9%) while 21 (5.1%) women had an insufficient serum 25 (OH) D. Serum 25 (OH) D ranged from 5.9-30.0 ng/ml. In the 2nd trimester, we confirmed 43 (10.43%) pregnant women with GDM out of 391 women with deficient serum 25 (OH) D level. 25 (OH) D deficiency was statistically significant (p = 0.035, OR = 0.963, 95% CI = 0.881-0.996) and associated with all GDM cases. Conclusion We conclude that 25 (OH) D deficiency was significantly correlated with GDM, as a consequence, the deficiency of 25 (OH) D could act as a risk factor for GDM. This result implies the necessity of focusing on vitamin D3 supplementation for women of childbearing age.

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“…Globally, vitamin D deficiency has been identified during pregnancy, but it is not clear whether or not this is physiological [28][29][30][31][32]. Some studies proved that low plasma vitamin D rates in the first 28 weeks of amenorrhea may be correlated to a higher risk of developing diabetes after the second trimester of pregnancy [33]. In everyday practice 25-[OH]D is tested, which is a free fraction that during pregnancy reaches the cells and is transformed into an activated hormone through a placenta receptor by placenta 1-alpha-hydroxylase enzyme [34].…”

Section: Resultsmentioning

confidence: 99%

Is There a Relation Between 25-Hydroxyvitamin D Deficiency and Gestational Diabetess

Petroaie¹,

Popovici²,

Cosmescu³

et al. 2020

Rev. Chim.

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One of the essential roles of vitamin D is to maintain a good state of health, its actions being extremely complex. In the past years, the role and involvement of vitamin D have been intensively discussed in a variety of physiological or pathological conditions. To be effective, vitamin D requires binding to specific nuclear receptors (VDRs) that are found in multiple tissues. Therefore, there is a great interest in studies focused on vitamin D in order to evaluate the potential functions and relations with gestational diabetes mellitus (GDM). This disease is defined by glucose intolerance with onset or first recognition during pregnancy. It presents an increased risk of later progression to type 2 diabetes. Now, gestational diabetes represents a global public health problem due to its increasing incidence and possible severe complications of pregnancy. This article centralizes recent studies focused on a possible link between vitamin D deficiency and gestational diabetes, knowing that in pregnant women the insufficiency or deficiency of that vitamin is a common thing.

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Relationship of Early Vitamin D Concentrations and Gestational Diabetes Mellitus in Indian Pregnant Women

Cited by 20 publications

References 42 publications

Maternal early pregnancy serum level of 25‐Hydroxyvitamin D and risk of gestational diabetes mellitus

Maternal early pregnancy serum level of 25‐Hydroxyvitamin D and risk of gestational diabetes mellitus

Early Pregnancy Maternal Vitamin D Deficiency and Risk of Gestational Diabetes Mellitus in Libyan Pregnant Women

Is There a Relation Between 25-Hydroxyvitamin D Deficiency and Gestational Diabetess

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