Relationship of EGFR DNA methylation with the severity of non-small cell lung cancer

Li, J; Jing, Xue; Liu, J; Liu, J J; Zhao, Hanxi

doi:10.4238/2015.october.5.5

Cited by 7 publications

(5 citation statements)

References 20 publications

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“…Thus, Li et al. discovered the importance of EGFR gene methylation, which was associated with malignancy of this type of cancer . In other study, patients with phospho‐EGFR‐positive tumors demonstrated a longer survival .…”

Section: Introductionmentioning

confidence: 98%

Epidermal growth factor receptor and notch signaling in non‐small‐cell lung cancer

Pancewicz-Wojtkiewicz

2016

Cancer Medicine

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Lung cancer is the most common reason of cancer deaths and about 85% of these are non‐small‐cell lung cancer. Currently, lung cancer therapy is mainly based on the tumor node metastasis (TNM) disease staging and tumor histological classification. Despite therapeutic innovations, the prognosis for lung cancer patients has not significantly changed in the last years. Therefore, a proper understanding of cell signaling pathways involved in cancer pathogenesis seems to be essential for improvement in cancer therapy field. The knowledge of crosstalk between epidermal growth factor receptor (EGFR) and Notch pathway can lead to enhanced screening for the expression of these genes allowing patients to optimize treatment options and predict potential treatment resistance. This review focuses on recent advances related to the mechanisms of EGFR and Notch signaling in non‐small‐cell lung cancer and the effectiveness of current Notch‐ and EGFR‐targeted therapies.

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Section: Introductionmentioning

confidence: 98%

Epidermal growth factor receptor and notch signaling in non‐small‐cell lung cancer

Pancewicz-Wojtkiewicz

2016

Cancer Medicine

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“…2020;24(9) NSCLC with low expression of EGFR (Pan, 2015). Moreover, higher DNA methylation level of EGFR indicates the stage of malignancy in these patients (Li, 2015)…”

Section: Non-small Cell Lung Cancermentioning

confidence: 99%

EGFR (Epidermal Growth Factor Receptor)

Hatil¹,

Çiçek²,

Oyken³

et al. 2020

Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ERBB family member epidermal receptor tyrosine kinase (EGFR) is composed of 28 exons and 27 introns. EGFR codes for 11 transcripts and 8 of them are protein coding. EGFR is a transmembrane glycoprotein that can be activated by several different ligands such as epidermal growth factor (EGF), transforming growth factor-alpha (TGFA), heparin-binding EGF-like growth factor (HBEGF), betacellulin (BTC), amphiregulin (AREG), epiregulin (EREG), and epigen (EPGN) (Singh, 2016). Ligand binding induces the dimerization of EGFR and autophosphorylation followed by a cascade of downstream phosphorylation events (Capuani et al., 2015). EGFR activation plays a key role in cell survival, proliferation, migration and differentiation (Purba, 2017).

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“…EGFR gene methylation was found to not be influenced by age, gender or smoking status of the patient, but rather found to increase with later stages. EGFR methylation may, therefore, be used as an indicator for the stage of cancer tissue malignancy [ 176 ].…”

Section: Dna Methylation As Prognostic Markermentioning

confidence: 99%

The Relevance of Gender in Tumor-Influencing Epigenetic Traits

et al. 2019

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Tumorigenesis as well as the molecular orchestration of cancer progression are very complex mechanisms that comprise numerous elements of influence and regulation. Today, many of the major concepts are well described and a basic understanding of a tumor's fine-tuning is given. Throughout the last decade epigenetics has been featured in cancer research and it is now clear that the underlying mechanisms, especially DNA and histone modifications, are important regulators of carcinogenesis and tumor progression. Another key regulator, which is well known but has been neglected in scientific approaches as well as molecular diagnostics and, consequently, treatment conceptualization for a long time, is the subtle influence patient gender has on molecular processes. Naturally, this is greatly based on hormonal differences, but from an epigenetic point of view, the diverse susceptibility to stress and environmental influences is of prime interest. In this review we present the current view on which and how epigenetic modifications, emphasizing DNA methylation, regulate various tumor diseases. It is our aim to elucidate gender and epigenetics and their interconnectedness, which will contribute to understanding of the prospect molecular orchestration of cancer in individual tumors.

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Relationship of EGFR DNA methylation with the severity of non-small cell lung cancer

Cited by 7 publications

References 20 publications

Epidermal growth factor receptor and notch signaling in non‐small‐cell lung cancer

Epidermal growth factor receptor and notch signaling in non‐small‐cell lung cancer

EGFR (Epidermal Growth Factor Receptor)

The Relevance of Gender in Tumor-Influencing Epigenetic Traits

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