Relationship of Endothelial Cell–Specific Molecule 1 Level in Stress Hyperglycemia Patients With Acute ST-Segment Elevation Myocardial Infarction

Abstract

Endothelial cell-specific molecule 1 ([ESM-1], endocan) is a new biomarker of endothelial dysfunction, which may be involved in the pathogenesis of atherosclerosis and stress hyperglycemia in patients with acute ST-segment elevation myocardial infarction (STEMI). Therefore, we investigated serum ESM-1 levels in patients with stress hyperglycemia having STEMI; 105 patients with STEMI and 33 individuals as a control group were included in the study. The patients were followed up for 3 months and major adverse cardiac events (MACEs) were recorded. Serum ESM-1 level was significantly higher in patients with stress hyperglycemia patients having STEMI (P < .05). In these patients, serum ESM-1 levels correlated positively with glucose levels (r = .21, P < .05). Multiple factor logistic regression analysis showed that serum ESM-1 levels >1.01 ng/mL (odds ratio 3.01, 95% confidence interval 1.05-8.64, P < .05) were an independent predictor of MACEs. Our findings suggest that ESM-1 is a novel biomarker overexpressed in patients with stress hyperglycemia having STEMI, admission glucose levels are associated with ESM-1 levels, and ESM-1 is an independent predictor of MACEs. An ESM-1 level >1.01 ng/mL is likely to predict a greater risk of MACEs.

The Relationship Between the Level of Serum ESM‐1 and Lp‐PLA2 in Patients With Acute ST‐Segment Elevation Myocardial Infarction

“…ESM‐1 was recognized as an important endothelial marker 11 . Our previous research indicated that ESM‐1 levels > 1.01 ng/mL were an independent indicator of major adverse cardiac events in patients with stress hyperglycemia having STEMI 12 . The correlation between EMS‐1 and high‐sensitivity C‐reactive protein levels and the neutrophil to lymphocyte ratio was also revealed in our investigation 13 .…”

“…In recent years, endothelial cell‐specific molecule 1 (ESM‐1) was recognized as an important endothelial marker, 11 which may be involved in the pathogenesis of atherosclerosis and lead to endothelial dysfunction 12 . The serum ESM‐1 level was suggested to be a novel biomarker for the diagnosis, evaluation, 12,13 or even staging 14 of acute STEMI. However, Aparci et al 15 .…”

Serum Endothelial Cell–Specific Molecule 1 (Endocan) Levels in Patients With Acute Myocardial Infarction and Its Clinical Significance

“…29 Elevated ESM-1 level may be associated with CVD. [30][31][32][33] Balta et al measured serum ESM-1 levels in 18 newly diagnosed patients with untreated essential hypertension (HT) and 23 control participants; serum ESM-1 levels were significantly higher in the HT group. 7 They also applied receiver-operating characteristic curves to predict the activity of HT and determine the cutoff value.…”

Relation of Carotid Artery Plaque to Coronary Heart Disease and Stroke in Chinese Patients: Does Hyperglycemia Status Matter?

“…Endothelial cell-specific molecule 1 (ESM-1) is a new biomarker of endothelial dysfunction, which is involved in the pathogenesis of atherosclerosis and stress induced hyperglycemia in patients. Admission glucose levels are associated with ESM-1 levels, and ESM-1 is an independent predictor of major adverse cardiac events [33]. Abnormal glycemic status is associated with carotid atherosclerosis, from early signs as demonstrated by the IMT presence of carotid plaques, to advance atherosclerosis [34].…”