Relationship of Epidermal Melanocytes and Langerhans Cells with Epidermal Cambial Cells

Abstract

Studies of mouse ear epidermis showed that proliferative activity of basal epidermal cells has two active and two passive phases throughout 24 h. Active phases consist of two subphases: long (proliferation of cambial cell descendants) and very short (cambial cell proliferation). Cambial cells proliferate at the boundary between active and passive phases; this results in an increase in the counts of epidermal melanocytes and Langerhans cells resultant from division of epidermal cambial cells. The count of Langerhans cells almost 2-fold surpasses melanocyte count, because melanocytes gradually transform into epidermal basal cells.

Agminated Spitzoid Naevi after Remission of Langerhans Cell Histiocytosis: First Italian Case and Literature Review

“…Thus, in predisposed patients, the specific trigger factor for the development of eruptive naevi could be frequent and localized friction (6). Considering the hypothesis of a common origin of epidermal melanocytes and Langerhans cells from epidermal cam-bial cells, we searched for the B-RAF mutation in both neoplastic Langerhans cells and naevocytic melanocytes (13). Indeed, B-RAF V600E mutant protein is considered a driver mutation in a proportion (≈55%) of LCH patients with activation of the MAPKinase RAS-RAF-MEK-ERK cell signalling pathway.…”

Epithelial tissue response to pathological effects in various age groups. Participation of morphofunctional zones and Src-kinase in this process

“…Thus, in the epithelial layer there are two flows of proliferating cells, the 1st stream -these are cambial cells and their earliest descendants (daughter, oval cells, the latter of which ultimately form reserve cells); The 2nd stream is the reserve cells and their derivatives: transitional and elongated, maturing in consequence into round and final cells. Cambial cells, compared to other cells, have a very short mitotic cycle, so their number in the population is judged by the content of daughter cells obtained during their division [6,7] . With aging, in norm a decrease in the proliferative activity of epithelial cells is observed.…”

Participation of an Inactive and Active Src-kinase in Formation of a Cytoskeleton and Melanogenesis in Hep2 Cells

“…The last directly enter into mitosis and further mature to final cells. Interestingly, that at the moment of the daughter cell stretching in the electric field there is not only cytoskeleton formation, but also an activization of tyrosinase activity of a cell occurs (Yavisheva et al, 2012). Therefore, the Srckinase participates simultaneously in cytoskeleton construction and activization of daughter cell tyrosinase.…”