Relationship of exercise and other risk factors to depression of Alzheimer's disease: the LASER‐AD study

Regan, Ciaran; Katona, Cornelius; Walker, Zuzana; Livingston, Gill

doi:10.1002/gps.1278

Cited by 51 publications

(33 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The present results support the notion that cerebrovascular and AD lesions represent additive or synergistic factors in the development of cognitive impairment associated with AD [Regan et al, 2005;Snowdon et al, 1997;Zekry et al, 2002]. Along this vein, it has been previously demonstrated [Snowdon et al, 1997] that patients of the ''Nun'' study with typical AD pathological markers at autopsy (neurite plaques and neurofibrillary tangles in the neocortex) had poorer cognitive function and higher prevalence of dementia when they had concomitant cerebrovascular lesions (lacunar infarcts in the basal ganglia, thalamus, or deep white matter); moreover, fewer neuropathologic lesions of AD were found in subjects with lacunar infarcts in the basal ganglia, thalamus, or deep white matter than in those without infarcts.…”

Section: Relationships Between White-matter Vascular Lesion and Frontsupporting

confidence: 89%

White matter vascular lesions are related to parietal‐to‐frontal coupling of EEG rhythms in mild cognitive impairment

Babiloni¹,

Frisoni²,

Pievani³

et al. 2007

Human Brain Mapping

View full text Add to dashboard Cite

Do cerebrovascular and Alzheimer's disease (AD) lesions represent additive factors in the development of mild cognitive impairment (MCI) as a putative preclinical stage of AD? Here we tested the hypothesis that directionality of fronto-parietal functional coupling of electroencephalographic (EEG) rhythms is relatively preserved in amnesic MCI subjects in whom the cognitive decline is mainly explained by white-matter vascular load. Resting EEG was recorded in 40 healthy elderly (Nold) and 78 amnesic MCI. In the MCI subjects, white-matter vascular load was quantified based on magnetic resonance images (0-30 visual rating scale). EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha1 (8-10.5 Hz), alpha2 (10.5-13 Hz), beta1 (13-20 Hz), and beta2 (20-30 Hz). Directionality of fronto-parietal functional coupling of EEG rhythms was estimated by directed transfer function software. As main results, (i) fronto-parietal functional coupling of EEG rhythms was higher in magnitude in the Nold than in the MCI subjects; (ii) more interestingly, that coupling was higher at theta, alpha1, alpha2, and beta1 in MCI V+ (high vascular load; N = 42; MMSE = 26) than in MCI V- group (low vascular load; N = 36; MMSE= 26.7). These results are interpreted as supporting the additive model according to which MCI state would result from the combination of cerebrovascular and neurodegenerative lesions.

show abstract

Section: Relationships Between White-matter Vascular Lesion and Frontsupporting

confidence: 89%

White matter vascular lesions are related to parietal‐to‐frontal coupling of EEG rhythms in mild cognitive impairment

Babiloni¹,

Frisoni²,

Pievani³

et al. 2007

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…Studies examining the effects of exercise in PWD showed improvements in depression [23][24][25] and lower rates of depression in exercisers compared with nonexercisers, although sample sizes have tended to be small, <30/group. 26 The type of tested exercise form varied, with home-based aerobic/ endurance activities, strength training, balance and flexibility training being most common.…”

Section: Background Effects Of Exercise On Cognitive Physical and Bmentioning

confidence: 99%

The Effects of a Multimodal Intervention on Outcomes of Persons With Early-Stage Dementia

Burgener

Yang

Gilbert³

et al. 2008

Am J Alzheimers Dis Other Demen

149

219

View full text Add to dashboard Cite

Theories supporting the existence of a use-dependent neuroplasticity in the older brain were used to guide this pilot study. A repeated-measures randomized design was used to test the effectiveness of a multimodal (Taiji exercises, cognitive-behavioral therapies, support group) intervention on cognitive functioning, physical functioning, and behavioral outcomes in persons with dementia. The treatment group (n = 24 persons with dementia) participated in a 40-week intervention, with outcomes assessed at 20 and 40 weeks to assess optimal treatment length. Control group subjects (n = 19 persons with dementia) received attention-control educational programs. At 20 weeks, differences between groups were found for mental ability and self-esteem, with gains in balance being evident. Also, stability in depression and physical health were evident at 20 and 40 weeks for treatment group subjects. Continued improvement in outcomes was not observed at 40 weeks. However, findings support further testing of the intervention along with potential for achieving positive outcomes in early-stage dementia.Keywords multimodal intervention; Taiji exercises; randomized design; cognition; balance Persons with dementia (PWD) experience progressive loss of cognitive, physical, and functional ability beyond that accounted for by normal aging processes. 1 Nonpharmacological interventions initiated early in the disease have the potential to improve outcomes, including cognition and functional ability. Functional status could be improved with exercise, but exercise interventions are rarely recommended for PWD, despite a large body of evidence showing the efficacy of exercise. 2 Studies supporting the effects of exercise on cognitive function have been conducted primarily in institutional settings and with persons at later disease stages. [2][3][4][5] Cognitive therapies have also been tested extensively in PWD with consistent improvements in cognitive outcomes that are comparable to drug trials. 6,7 Support programs, such as support groups, have been used with PWD for over a decade, although systematic studies of the benefits of support programs are lacking. Few studies, however, have tested multimodal interventions that combine exercise, cognitive therapies, and support programs for persons in the early to early-middle stages of NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript dementia. 8 The purpose of this pilot study was to test the feasibility and the effects of a multimodal intervention (Taiji exercise, cognitive therapies, and support group) on cognitive functioning, physical functioning, and behavioral outcomes of PWD. The research questions guiding this pilot study included 1. What are the effects of a multimodal intervention (Taiji exercise, cognitivebehavioral therapies [CBT], and support group) on cognitive functioning, physical functioning, and behavioral outcomes of PWD compared with PWD not receiving the intervention? It was hypothesized that the treatment group would show improved cognitive fun...

show abstract

“…This is part of a larger naturalistic study of people with Alzheimer's disease and their caregivers (London and South-East Region Alzheimer's disease Study, LASER-AD; Livingston et al, 2004;Hoe et al, 2005;Regan et al, 2005;Mahoney et al, in press). Participants were chosen to be epidemiologically representative of the wider community of people with AD in terms of gender, severity of illness and living settings.…”

Section: Methodsmentioning

confidence: 99%

The TE4D-Cog: a new test for detecting early dementia in English-speaking populations

Mahoney

Johnston

Maxmin

et al. 2005

Int. J. Geriat. Psychiatry

Self Cite

View full text Add to dashboard Cite

show abstract

Relationship of exercise and other risk factors to depression of Alzheimer's disease: the LASER‐AD study

Abstract: None of the traditional risk factors for depression in older people were associated with depression in AD. Taking regular exercise may protect against depression in AD.

Cited by 51 publications

References 59 publications

White matter vascular lesions are related to parietal‐to‐frontal coupling of EEG rhythms in mild cognitive impairment

White matter vascular lesions are related to parietal‐to‐frontal coupling of EEG rhythms in mild cognitive impairment

The Effects of a Multimodal Intervention on Outcomes of Persons With Early-Stage Dementia

The TE4D-Cog: a new test for detecting early dementia in English-speaking populations

Contact Info

Product

Resources

About