Relationship of follicle number, serum estradiol level, and other factors to clinical pregnancy rate in gonadotropin-induced intrauterine insemination cycles

Özçakır, Hasan Tayfun; Göker, Ege Nazan Tavmergen; Terek, Mustafa Coşan; Adakan, Şaban; Ulukuş, Murat; Levi, Rafael; Tavmergen, Erol

doi:10.1007/pl00007493

Cited by 15 publications

(10 citation statements)

References 7 publications

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“…Estrogen increases endometrial proliferation and uterine perfusion which improves the chance of pregnancy. E2 may disrupt the implantation process through endometrial damage which is responsible for the negative effect of E2 on IVF-ICSI outcome [9]. Despite the well-designed structure, the present study possesses some limitations, as follows (i) the number of included subjects was small (ii) no follow-up of patients for clinical pregnancy and live birth rate.…”

Section: Discussionmentioning

confidence: 94%

“…Kyrou [7] have reported a lack of association in antagonist cycles and basal FSH [7]. Ozcakir et al [9] have evaluated this association after use of clomiphene citrate and HMG followed by intrauterine insemination of 180 patients and reported that there is no correlation between E2 level and clinical pregnancy [9]. Also, Mitwally et al [8] have investigated the association of E2 level during COH and peak E2 pregnancy outcome in 270 patients and reported the positive correlation between estradiol during COH and pregnancy outcome, but not between E2 on hCG administration day and pregnancy outcome.…”

Section: Discussionmentioning

confidence: 98%

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Association Between Serum Estradiol Level on the Day of hCG Administration and IVF–ICSI Outcome

Foroozanfard

Moraveji

Taghavi

et al. 2015

J Obstet Gynecol India

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Background Controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF) is essential in improving the pregnancy rate, but supraphysiologic levels of estradiol (E2), which are attained during COH and which affect the outcome of IVF, have remained unclear. The aim of this study was to evaluate the association of E2 levels on the day of hCG with embryo quality and pregnancy rates in long protocol in IVF. Materials and Methods We retrospectively reviewed 128 IVF cycles. All the patients were stimulated with long protocol. The patients were categorized into three groups according to the serum E2 levels on hCG administration day (group 1; \1500 pg/ml, group 2; 1500-3500 pg/ml, group 3; [3500 pg/ml). Results Of the 128 cycles, 23 (18 %) cycles resulted in pregnancy. There were no statistically significant differences between mean age, duration of infertility, BMI and FSH on cycle day 3 in three groups. The number of the retrieved oocytes, the number of obtained embryos, the number of transferred embryos, and pregnancy rates were gradually increased from group 1 to 3 as estradiol levels increased, and these values were statistically significant (P \ 0.05). In addition, the correlation between age and IVF outcome was found. Mean age in patients with positive

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 98%

Association Between Serum Estradiol Level on the Day of hCG Administration and IVF–ICSI Outcome

Foroozanfard

Moraveji

Taghavi

et al. 2015

J Obstet Gynecol India

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“…Low total motile sperm count might not have been affected significantly in the second attempt. The outcome of COH-IUI cycles may be effected by many parameters such as, age, duration of infertility, dose of medication and the number of mature follicles 9,10 . In our study, there was no significant difference between the groups regarding these variables.…”

Section: Discussionmentioning

confidence: 99%

“…Controlled ovarian hyperstimulation (COH) combined with IUI may improve cycle fecundity rate compared with timed intercourse presumably due to increased number of oocytes available for fertilization 7,8 . Some factors such as sperm I count 9 and number of follicles developed have been positively related to pregnancy rate, whereas advanced female age and high cycle number have been negatively associated 10 .…”

Section: Introductionmentioning

confidence: 99%

Single Versus Double Intrauterine Insemination in Controlled Ovarian Stimulation Cycles for Subfertile Males

Alwaeely¹

2012

Basrah Journal of Surgery

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This study aimed to compare the efficacy of single intrauterine insemination (IUI) with double IUI in controlled ovarian hyperstimulation (COH) and IUI cycles for subfertile males. This is a prospective, nonrandomized study in hospital based outpatient infertility center. The subfertile males were diagnosed by at least two sperm analyses. The study included ovulatory women having patent tubes and undergoing COH cycles with either single or double IUI. Controlled ovarian hyperstimulation was induced by either clomiphene citrate (CC) with gonadotropins or only gonadotropins. Intrauterine insemination of husband's sperm was performed 36 hours after hCG administration in single IUI group. In the double IUI group, first IUI was performed 12-18 hours and second IUI 36 hours after hCG administration. The decision as to which intervention group a patient was placed in was determined by the day of hCG administration. Ovarian response to hyperstimulation was the only factor influencing the day of hCG administration. Statistical analyses was carried out by using the student's t test and chisquared test. The main outcome measure is Clinical Pregnancy rate (CPR). Pregnancy was determined ultrasonographically by the presence of fetal cardiac activity. A total of 191 couples underwent 216 COH-IUI cycles; 110 couples underwent 124 cycles with single IUI and 81 couples underwent 92 cycles with double IUIs. Cycle pregnancy rates were 9.2% (12/124) in the single IUI group and 8.2% (9/92) in the double IUI group, respectively (p=0.782). It is concluded that a single IUI may be as effective as double IUI for couples undergoing COH/IUI for subfertile males.

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“…Peak estradiol should be a true reflection of the entire developing follicular cohort, both large- and intermediate-sized follicles. Some authors [8, 9] have found a correlation between peak estradiol and the number of follicles while others have not [11]. Adding to the confusion are significant differences between studies in terms of which follicle sizes they have considered “large” and whether they have used mean or largest diameter.…”

Section: Introductionmentioning

confidence: 99%

Multiple Pregnancy after Gonadotropin-Intrauterine Insemination: An Unavoidable Event?

Fong

Palta

et al. 2011

ISRN Obstetrics and Gynecology

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Objective. Determine which factors predict multiple pregnancy in gonadotropin-intrauterine insemination cycles so that cancellation criteria might be developed. Study Design. Retrospective chart review of all patients undergoing gonadotropin-intrauterine insemination over a continuous 36 month period. Results. No factors examined were able to predict the occurrence of multiple pregnancy. Conclusion. Multiple pregnancy is an unavoidable complication of gonadotropin-intrauterine insemination treatment.

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Relationship of follicle number, serum estradiol level, and other factors to clinical pregnancy rate in gonadotropin-induced intrauterine insemination cycles

Cited by 15 publications

References 7 publications

Association Between Serum Estradiol Level on the Day of hCG Administration and IVF–ICSI Outcome

Association Between Serum Estradiol Level on the Day of hCG Administration and IVF–ICSI Outcome

Single Versus Double Intrauterine Insemination in Controlled Ovarian Stimulation Cycles for Subfertile Males

Multiple Pregnancy after Gonadotropin-Intrauterine Insemination: An Unavoidable Event?

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