Objective: To analyze the capability of cone-beam computed tomography (CBCT) to accurately identify low bone mass density in women.Methods: A systematic search of Medline, Embase, Scopus, Google Scholar, Cochrane Library, and Science Direct was conducted to identify the relevant articles. A detailed inclusion and exclusion criterion was developed and implemented to screen the abstracts. Full texts of the selected studies were then evaluated to establish their inclusion or exclusion in our review. Cochrane risk of bias criterion was used to determine the methodological quality of the included studies. All relevant data were extracted, and the results were summarized narratively.Results: Ten studies met out inclusion-exclusion criteria and were included in this systematic review. All of the included studies assessed primary research on the capacity of CBCT to accurately diagnose insufficient bone mineral density. The results indicated that CBCT has good sensitivity and specificity, and high accuracy in predicting osteoporosis. Four of the included studies measured qualitative values while others concentrated on quantitative values and found lower values in osteoporosis patients compared to osteopenic and healthy patients. All of these studies compared CBCT grayscale values with DEXA scores which strengthened our confidence in the accuracy of CBCT diagnostic capability.Conclusion: Given the common use of CBCT in dental practices and the high prevalence of osteoporosis in postmenopausal women, the evidence on the capacity of CBCT to predict osteoporosis is somewhat finite. Although this systematic review provides good evidence regarding the ability of CBCT for predicting osteoporosis, further research is needed to confirm the evidence and enhance its generalisability.