Relationship of histopathologic features to survival and relapse in nodular sclerosing Hodgkin's disease. A study of 1659 patients

Abstract

ODULAR SCLEROSIS (NS) is a distinctive pathologicN subtype of Hodgkin's disease (HD) that is characterized by a nodular growth pattern, intranodal collagen band formation, and the presence of lacunar cells.'-4 NS does not coexist with or transform into other pathologic subtypes of HD.'-' This has led to the proposition that "the classification of NS takes precedence over other histological types which appear to be present in the same section."' NS is the most commonly recognized histopathologic subtype of HD in many studies.'-I3 In the clinical trials of HD conducted by the British National Lymphoma Investigation (BNLI),I4 75% of the cases were classified as NS. The cellular nodules of NS may show a wide variety of cytologic appearances which range from a predominance of lymphocytes to lymphocyte depletion with numerous Hodgkin's cells.8 Since the first publication by Cross,'' there have been several reports attempting to correlate pathologic features with prognosis in NS.'6-24 The results have been generally inconclusive, largely due to the relatively small number of cases included. This prompted us to undertake a histologic review of the diagnostic lymph node biopsy spec-

The Ratio of the Absolute Lymphocyte Count to the Absolute Monocyte Count Is Associated with Prognosis in Hodgkin's Lymphoma: Correlation with Tumor-Associated Macrophages

“…However, BNLI grade was not prognostic for the OS outcome (data not shown), which is consistent with results from another Asian study [31]. Previous studies on BNLI grading have yielded contradictory results [32][33][34][35][36][37][38][39].…”

Epstein–Barr virus expression in Hodgkin’s disease in relation to patient characteristics, serum factors and blood lymphocyte function

“…The histopathology and the immunophenotyping of all biopsies were reviewed (AP) and, when necessary, complementary immunostainings for CD15, CD30, CD20 and, in addition, LN-1, CD79a, CD3, UCHL-1 and EMA were performed to confirm the diagnosis. The REAL classification (Harris, 1995) was applied including the division of nodular sclerosis (NS) according to the British National Lymphoma Investigation (MacLennan et al, 1989). There were 59 patients with NS and 33 patients with mixed cellularity (MC).…”

Anaplastic large cell lymphoma: pathology, genetics, and clinical aspects

“…37 However, after ALK immunostaining was developed, some cases thought to be HL-ALCL were shown to be negative for ALK and were subsequently reclassified as variants of CHL rich in tumor cells. Conversely, some histologically aggressive, prognostically poor subgroups of CHL, 38 including NSCHL grade II or lymphocyte-depleted CHL, were found to be within the morphological spectrum of ALCL if ALK expression was identified. Now that ALCL is recognized as a T/null-cell neoplasm with ALK translocation, whereas CHL is a B-cell neoplasm without ALK translocation, the identification of ALK expression/translocation is the most definitive criterion distinguishing ALCL from CHL.…”