Relationship of Histopathology Grading with Molecular Subtypes of Breast Cancer Patients in Haji Adam Malik General Hospital 2016-2018

Furqan, Muhammad; Pohan, Pimpin Utama

doi:10.32734/scripta.v2i1.3364

Cited by 5 publications

(5 citation statements)

References 18 publications

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“…29 Di Indonesia, tipe luminal A terbanyak ditemukan di RS Sarjito Yogyakarta, RS Hasan Sadikin Bandung, dan RS Adam Malik Medan. 28,30,31 Di RS Sanglah Denpasar frekuensi tipe luminal A sama banyak dengan triple negative. 13 Tidak seperti pada pasien dengan tipe Luminal A yang mempunyai gambaran faktor risiko seperti usia lebih tua untuk kehamilan pertama, indeks masa tubuh lebih tinggi, paritas lebih rendah, kurang menyusui dengan frekuensi yang lebih sering, 32 pada tipe luminal B, modifikasi gaya hidup seperti aktivitas fisik maupun faktor reproduksi kurang berhubungan dengan risiko terjadi kanker payudara tipe luminal B 33 .…”

Section: Pembahasanunclassified

Subtipe Molekuler Kanker Payudara di RSUD Madiun dan Hubungannya dengan Grading Histopatologi

Subiyanto

Kadi²,

Ismaiyah³

et al. 2021

mpk

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Breast cancer is a complex disease with variable molecular characteristics and shows different tumor behavior, therapeutic response, and prognosis. The regional general hospital Madiun has begun to improve services for breast cancer patients since 2015 with the availability of immunohistochemical examinations. This effort was made because breast cancer therapy is currently guided by these examinations. This study aimed to determine the distribution of various molecular subtypes of breast cancer in Madiun Hospital and also the relationship between molecular subtypes and histopathological grading. This study was a retrospective study with a cross-sectional design taken from the Anatomical Pathology Laboratory of Madiun Hospital data from 2015 to 2018. A total of 281 breast cancer cases were examined for immunohistochemical of estrogen receptor (ER), progesterone receptor (PR), and human epidermal receptor 2 (HER2), and a total of 91 breast cancer patients plus Ki-67 examination were then classified into luminal A, luminal B, HER2 and triple-negative (TN). The statistical test used was the Chi-Square test with a 95% confidence level. The most common molecular subtypes of breast cancer in Madiun Hospital were luminal B (28,5%) followed by TN (27,5%), luminal A (22%), and HER2 (22%). The mean age of breast cancer patients was 52.8 ± 10.57. The most common histological types and grades of breast cancer were invasive ductal carcinoma (85.1%) and tumor grade 1 (58.71%). There was a correlation between the immunohistochemical features of ER, PR, HER2, and Ki67 withhistopathological grading. Positive ER and PR were more well differentiated but e HER2 positive andKi67 were more poorly differented. Abstrak Kanker payudara merupakan penyakit kompleks dengan gambaran molekuler bervariasi dan menunjukkan perilaku tumor, respon terapi, dan prognosis yang berbeda. Rumah Sakit Umum Daerah (RSUD) Madiun mulai meningkatkan layanan untuk pasien kanker payudara sejak tahun 2015 dengan tersedianya pemeriksaan imunohistokimia. Upaya ini dilakukan karena terapi kanker payudara saat ini berpedoman atas pemeriksaan tersebut. Penelitian ini bertujuan untuk mengetahui distribusi berbagai subtipe molekuler kanker payudara di RSUD Madiun dan juga hubungan antar subtipe molekuler dengan grading histopatologi. Penelitian ini adalah studi retrospektif dengan desain cross sectional yang diambil dari data Laboratorium Patologi Anatomi RS Madiun selama tahun 2015 sampai 2018. Total 281 kasus kanker payudara dilakukan pemeriksaan imunohistokimia estrogen receptor (ER), progesteron receptor (PR) dan human epidermal epidermal receptor 2 (HER2) dan total 91 pasien kanker payudara ditambah pemeriksaan Ki-67 kemudian diklasifikasikan menjadi luminal A, luminal B, HER2, dan triple negative (TN). Uji statistik yang digunakan adalah uji Chi Square dengan taraf kepercayaan 95%. Subtipe molekuler kanker payudara di RS Madiun yang paling banyak adalah luminal B (28,5%) diikuti TN (27,5%), luminal A (22%), dan HER2 (22%). Rata-rata umur pasien kanker payudara adalah 52,8 ±10,57. Tipe histologi dan grade kanker payudara terbanyak adalah karsinoma duktal invasif (85,1%) dan grade tumor 1 (58,71%). Terdapat hubungan gambaran imunohistokimia baik ER, PR, HER2 dan Ki67 dengan grading histopatologi. ER dan PR positif lebih banyak mengalami diferensiasi baik namun HER2 positif dan KI67 positif lebih banyak mengalami diferensiasi buruk.

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Section: Pembahasanunclassified

Subtipe Molekuler Kanker Payudara di RSUD Madiun dan Hubungannya dengan Grading Histopatologi

Subiyanto

Kadi²,

Ismaiyah³

et al. 2021

mpk

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show abstract

“…To exemplify the benefit of this study in issuing the imbalance of trial-patient rate, the US National Library of Medicine only recorded a single-active trial of TNBC in Indonesia; though Indonesia is placing the fourth in total population (2023 report by the Worldometer, 49.7% is female; approximately ± 135 million individuals) [6,61]. We also estimated that 17.8% of the BC diagnosis in Indonesia is triple-negative on IHC [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. Supported by the GLOBOCAN 2020 country-specific report, at least there was 65,858 total BC cases (in which 11,000 -12,000 of the patients are estimated to be TNBC on testing) [1].…”

Section: Discussionmentioning

confidence: 99%

Intercontinental Comparison of Immunohistochemical Subtypes Among Individuals With Breast Cancer in South-East Asia and South America: A Scoping Systematic Review and Meta-Analysis of Observational Studies

Hermansyah,

Firsty,

Siagian

et al. 2024

World J Oncol

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Background Breast cancer (BC) remains a significant global concern, particularly among developing countries in South-East Asia (SEA) and South America (SA). The socioeconomic burdens of oncologic care in those countries were often originated from limited accessibility on attainable therapeutic options and reliability on identifying essential information of cancer cells, i.e., immunohistochemical (IHC) subtyping to determine suitable approaches. The triple-negative breast cancer (TNBC) is among the most aggressive category in breast malignancy, therefore, requiring more specific molecular pathway blocking to exhaust the cells. However, large-scale epidemiological investigation on its rate among BC remains unavailable to date. This study aimed to describe the prevalence of TNBC in the SEA and SA continents since it may guide the future direction of oncologic research and trials. Methods This review focuses on observational studies from the SEA and SA continents from the last decade. Each study represents its country or cities, period of observation, population size, and the TNBC-BC rate as the main outcomes. Therefore, we may also limit the reporting bias originated from same-patient data on the specific occasions. The analysis will be derived to SEA-SA comparison, plus SEA/SA-specific session as processed in Comprehensive Meta-Analysis (CMA) version 3.0. The statistical analysis will be performed in random effects model (REM) within 95% confidence interval (CI). Results From 46 studies included in the final analysis with a total enlisted population of 34,346 unique individuals with BC, the TNBC rate was higher in the SEA compared to the SA region (19.3% vs. 15.7%; P < 0.05 in 95% CI), with the highest prevalence observed in Vietnam (22.4%) and Peru (17.8%), if it was restricted on countries with two or more studies. Interestingly, both Laos and Argentina possessed significant differences compared to other countries within their respective continents, with the highest and lowest TNBC rates (P < 0.05). Conclusions The IHC characteristics in SEA differ from those in the SA continent as mainly represented by TNBC prevalence, possibly shaping the course of future trials in the respective region based on IHC expressivity status.

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“…These findings are consistent with several other studies which show that breast carcinoma with triple negative and HER2 positive molecular subtypes mostly has a high histopathological grading. 20,21 Mutations of p53, deregulation of Rb and integrin, overexpression of EGFR and decreased expression of PTEN, have important roles in increasing the histopathological grade of breast carcinoma, which is associated with poor prognosis and increases the aggressiveness of breast carcinoma. 22…”

Section: Discussionmentioning

confidence: 99%

Comparison of MMP-9 Density Between Triple Negative and HER2 Enriched Breast Carcinoma Subtypes

Putra Pratama,

Dewi,

Aspitriani

et al. 2023

MPI

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Background Matrix metalloproteinase-9 (MMP-9) is a protease that plays an important role in various biological processes of breast cancer. This marker may be useful in determining the prognosis and become a promising therapy, especially in breast carcinoma with an aggressive subtype including HER2 enriched and triple negative. Both subtypes have high MMP-9 expression, but it is necessary to differentiate them because they have different biological and molecular aspects. This study aims to compare the density of MMP-9 between triple negative and HER2 enriched breast carcinoma subtypes and their relationship with clinicopathological characteristics. Methods This is a cross sectional study using 32 samples of paraffin blocks and slides of breast carcinoma patients with triple negative and HER2 Enriched subtypes at the Department of Anatomical Pathology Faculty of Medicine Sriwijaya University/Dr. Mohammad Hoesin Hospital Palembang for the period January 1, 2016 to December 31, 2019. Each sample was stained with MMP-9 antibodies immunohistochemistry (polyclonal, Abcam). Comparative analysis of MMP-9 density between the two subtypes was carried out using the median value based on the Mann-Whitney analysis. MMP-9 density was categorized as high and low based on the ROC curve and analyzed by using chi-square test to assess its association with clinicopathological characteristics. Results Mann-Whitney test showed that the MMP-9 density was higher in the HER2 enriched subtype (median 12.0) than triple negative (median 8.8) with a p value of 0.632. The relationship distribution of high MMP-9 density was found in the category of age group >40 years old (60.0%), positive lymphovascular invasion (86.7%) and histological grade III (80.0%) with p values of 0.798, 0.402 and 0.691. Conclusion MMP-9 density in HER2 enriched subtype was higher than triple negative subtype, but statistically not significant.

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Relationship of Histopathology Grading with Molecular Subtypes of Breast Cancer Patients in Haji Adam Malik General Hospital 2016-2018

Cited by 5 publications

References 18 publications

Subtipe Molekuler Kanker Payudara di RSUD Madiun dan Hubungannya dengan Grading Histopatologi

Subtipe Molekuler Kanker Payudara di RSUD Madiun dan Hubungannya dengan Grading Histopatologi

Intercontinental Comparison of Immunohistochemical Subtypes Among Individuals With Breast Cancer in South-East Asia and South America: A Scoping Systematic Review and Meta-Analysis of Observational Studies

Comparison of MMP-9 Density Between Triple Negative and HER2 Enriched Breast Carcinoma Subtypes

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