Relationship of <i>Porphyromonas gingivalis</i> with glycemic level in patients with type 2 diabetes following periodontal treatment

Makiura, N.; Ojima, Miki; Kou, Yurong; Furuta, Nobumichi; Okahashi, Nobuo; Shizukuishi, Satoshi; Amano, Atsuo

doi:10.1111/j.1399-302x.2007.00426.x

Cited by 118 publications

(95 citation statements)

References 24 publications

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“…It was observed that post-treatment, P. gingivalis was detected more frequently in those who had increased HbA1c values compared to those with decreased values relative to baseline, and more specifically, P. gingivalis with type II fimbriae was detected only in patients with an increase in HbA1c. The authors postulated that glycaemic control in patients with periodontitis and diabetes is potentially influenced by the persistence of P. gingivalis, particularly clones with type II fimbriae, following treatment (Makiura et al 2008). It has also been reported in in vitro studies that cytokine induction (specifically IL-1b, IL-8, IL-12 and TNF-a) by P. gingivalis with type II fimbriae is greater than that induced by P. gingivalis with type I fimbriae (Sugano et al 2004), and in animal studies that P. gingivalis inoculation can lead to elevated serum levels of TNF-a and IL-6 (Nishihara et al 2009).…”

Section: Microbial Factorsmentioning

confidence: 99%

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A review of the evidence for pathogenic mechanisms that may link periodontitis and diabetes

Taylor

Preshaw

Lalla

2013

Journal of Periodontology

218

258

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A review of the evidence for pathogenic mechanisms that may link periodontitis and diabetes Taylor JJ, Preshaw PM, Lalla E. A review of the evidence for pathogenic mechanisms that may link periodontitis and diabetes.Abstract Aims: To review the evidence for the molecular and cellular processes that may potentially link periodontal disease and diabetes. The pathogenic roles of cytokines and metabolic molecules (e.g. glucose, lipids) are explored and the role of periodontal bacteria is also addressed. Paradigms for bidirectional relationships between periodontitis and diabetes are discussed and opportunities for elaborating these models are considered. Methods: Database searches were performed using MeSH terms, keywords, and title words. Studies were evaluated and summarized in a narrative review. Results: Periodontal microbiota appears unaltered by diabetes and there is little evidence that it may influence glycaemic control. Small-scale clinical studies and experiments in animal models suggest that IL-1b, TNF-a, IL-6, OPG and RANKL may mediate periodontitis in diabetes. The AGE-RAGE axis is likely an important pathway of tissue destruction and impaired repair in diabetesassociated periodontitis. A role for locally activated pro-inflammatory factors in the periodontium, which subsequently impact on diabetes, remains speculative. Conclusion: There is substantial information on potential mechanistic pathways which support a close association between diabetes and periodontitis, but there is a real need for longitudinal clinical studies using larger patient groups, integrated with studies of animal models and cells/tissues in vitro.

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Section: Microbial Factorsmentioning

confidence: 99%

“…One study of 30 Japanese adults with chronic periodontitis and type 2 diabetes considered this issue (Makiura et al 2008). All patients received non-surgical periodontal therapy, and subgingival plaque samples were collected at baseline and up to 12 months following therapy.…”

Section: Microbial Factorsmentioning

confidence: 99%

A review of the evidence for pathogenic mechanisms that may link periodontitis and diabetes

Taylor

Preshaw

Lalla

2013

Journal of Periodontology

218

258

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“…Furthermore, P. gingivalis organisms with type II fimbriae were detected only in subjects with elevated HbA1c, while improvements in HbA1c levels were observed only in subjects without type II clones. These results suggest that glycemic level in diabetes mellitus is affected by the persistence of P. gingivalis in periodontal pockets, especially clones with type II fimbriae (18). Serum advanced glycation end products (AGEs) were also shown to be significantly associated with deterioration caused by periodontitis (15) and may be a useful biomarker to assess periodontitis associated with diabetes mellitus.…”

Section: Diabetes Mellitusmentioning

confidence: 86%

Roles of Oral Bacteria in Cardiovascular Diseases — From Molecular Mechanisms to Clinical Cases: Implication of Periodontal Diseases in Development of Systemic Diseases

Inaba

Amano

2010

J Pharmacol Sci

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Abstract. Periodontal diseases, some of the most common infectious diseases seen in humans, are characterized by gingival inflammation, as well as loss of connective tissue and bone from around the roots of the teeth, which leads to eventual tooth exfoliation. In the past decade, the association of periodontal diseases with the development of systemic diseases has received increasing attention. Although a number of studies have presented evidence of close relationships between periodontal and systemic diseases, the majority of findings are limited to epidemiological studies, while the etiological details remain unclear. Nevertheless, a variety of recent hypothesis driven investigations have compiled various results showing that periodontal infection and subsequent direct oral-hematogenous spread of bacteria are implicated in the development of various systemic diseases. Herein, we present current understanding in regard to the relationship between periodontal and systemic diseases, including cardiovascular diseases, preterm delivery of low birth weight, diabetes mellitus, respiratory diseases, and osteoporosis.

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“…As periodontal disease develops, a shift occurs in the relative abundance of specific species. Elevated numbers of Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola, which form the red-microbial complex, correlate with gingivitis, chronic periodontitis, acute necrotizing ulcerative gingivitis, endodontic lesions, and have been associated with cardiovascular disease, stroke, endometriosis, preterm delivery of low-birthweight infants, and diabetes mellitus (Socransky et al, 1998;Yuan et al, 2001;Kshirsagar et al, 2007;Chen et al, 2008;Makiura et al, 2008;Kavoussi et al, 2009;Inaba and Amano, 2010). While oral Treponemes constitute a low percentage of the bacterial population in gingival crevicular fluid of healthy individuals, they are abundant in periodontal pockets Ellen and Galimanas, 2005).…”

Section: Introductionmentioning

confidence: 99%

Molecular Signaling Mechanisms of the Periopathogen, Treponema denticola

et al. 2011

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In the healthy subgingiva, oral treponemes account for a small percentage of the total bacteria. However, in diseased periodontal pockets, treponemes thrive and become a dominant component of the bacterial population. Oral treponemes are uniquely adept at capitalizing on the environmental conditions that develop with periodontal disease. The molecular basis of adaptive responses of oral treponemes is just beginning to be investigated and defined. The completion of several treponeme genome sequences and the characterization of global regulatory systems provide an important starting point in the analysis of signaling and adaptive responses. In this review, we discuss existing literature focused on the genetic regulatory mechanisms of Treponema denticola and present an overview of the possible roles of regulatory proteins identified through genome analyses. This information provides insight into the possible molecular mechanisms utilized by oral spirochetes to survive in the periodontal pocket and transition from a minor to a dominant organism.

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Relationship of Porphyromonas gingivalis with glycemic level in patients with type 2 diabetes following periodontal treatment

Abstract: These results suggest that glycemic level in diabetes is affected by the persistence of P. gingivalis, especially clones with type II fimbriae, in periodontal pockets.

Cited by 118 publications

References 24 publications

A review of the evidence for pathogenic mechanisms that may link periodontitis and diabetes

A review of the evidence for pathogenic mechanisms that may link periodontitis and diabetes

Roles of Oral Bacteria in Cardiovascular Diseases — From Molecular Mechanisms to Clinical Cases: Implication of Periodontal Diseases in Development of Systemic Diseases

Molecular Signaling Mechanisms of the Periopathogen, Treponema denticola

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