Relationship of IL-6 gene polymorphisms and IL-6 expression level with the burn-induced sepsis susceptibility in Al Diwaniyah

Breast cancer is the most prevalent form of cancer in women and is the leading cause of global cancer-related mortality. The study aimed to assess the changes in some serum biomarkers linked to immunity responses in Iraqi breast cancer patients and understand their multifaceted role in the disease's progression. The current investigation comprised a cohort of 55 women diagnosed with breast cancer and a control group of 45 healthy participants. The levels of interleukin-6 (IL-6), interleukin-10 (IL-10), and C-reactive protein (CRP) were estimated in the serum of breast cancer patients. The results showed that patients with breast cancer had a significant increase (p<0.05) in IL-6, IL-10, and CRP serum concentrations as compared to healthy women. These findings give support to the evidence suggesting that these markers may play an essential role in the progression of breast cancer.

Section: Resultsmentioning

confidence: 99%

Evaluation of the Serum Levels of Interleukin-6, Interleukin-10, and C-Reactive Protein in Iraqi Women with Breast Cancer

Ibraheem Muhesin,

Abbas Hadi

2023

The role of IL-4 −590 (C>T) Gene as diagnostic biomarker of Hashimoto thyroiditis disease patients in AL-Najaf provenance /Iraq

AL-Huchaimi,

AL-Ammar,

AL-Fatlawi

2023

The study of IL-4 genotyping in Hashimoto patients is considered one of the challenges of sustainable development .Hashimoto disease is an autoimmune disease that causes the immune system to attack the cells of the thyroid gland, causing the death of the cells that produce thyroid hormones, and thus leads to chronic hypothyroidism. The aim of current study is to determine the genotyping of IL-4 -590C>T in the DNA of Hashimoto patients and compared with healthy subjects .A 54 blood samples were collected from people with Hashimoto's disease and 25 samples from healthy people during period from March to September of the year 2022 , DNA was extracted from blood using Favorprep Kit, then, using a specific primers for the C and T alleles of interleukin 4-590 C/T, then doubled using Arms PCR. Then, they were transported in agarose gel with the ethidium bromide dye and detected by the gel documentation system , ultraviolet rays use to determine the type of alleles present in each sample and compared with control group. The current study, which includes 50/54 female and 4/54 male with Hashimoto thyroiditis with ages ranged from 20-59 years old, the results show up that the age group 40-49 years were the most affected, Also the body mass index was had increases among patients. CT genotype present in 74% of Hashimoto patients while 16% of control. C allele was found as high rate in both patients and control with percentage 100% and 96% respectively. in conclusion: The Hashimoto patients have more frequency of CT genotyping of IL-4 -590 C>T than control ,while C Allele was high in both Hashimoto patients and controls. The -590 CC genotype in the IL4 gene may consider to be a strong predictive factor for the development of hypothyroidism in HD.

The Role Of MicoRNA 146-A (Rs2910164) In Otitis Media Patients In AL-Najaf Provenance/Iraq

Mohammed Hadi Al-fatlawi,

Alammar,

Lafta Al Mansoori

2023

The current study aims to shows the relationship between gene polymorphisms (SNP( of miRNA 146-a of patients infected with otitis media. This finding included 50 samples collected from healthy subject and 100 samples from a patienst suffering from otitis media who attended Al-Sadr Medical City (ENT Department) in Al-Najaf Governorate during the period from February 2022 to June 2022. The samples had an average age ranging from 5 to 70 years. Genotyping of miRNA 146-a revealed the presence of three genotypes: GG, CG, and CC, representing (16%, 47%, and 37%) respectively in patients with otitis media, while it was (27%, 18%, and 55%) respectively in healthy subjects. CG was common in patients while GG was more common in healthy subjects. MiRNA as potential biomarker of patients infected with otitis media.