Relationship of intercapillary area with visual acuity in diabetes mellitus: an optical coherence tomography angiography study

Tang, Florence; Sun, Zihan; Wong, Raymond Siu Ming; Lok, Jerry; Lam, Alexander; Tham, Clement C.; Chan, Carmen K. M.; Mohamed, Shaheeda; Lam, Thomas Y.; Szeto, Simon; Ng, David C.; Cheung, Carol Y.

doi:10.1136/bjophthalmol-2018-312010

Cited by 22 publications

(11 citation statements)

References 28 publications

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“…However, pre-treatment mean ICA was significantly associated with baseline BCVA. Our results are similar to Tang et al, 28 who confirmed the relationship between ICA and BCVA and DR severity in their cross sectional study over 477 eyes.…”

Section: Discussionsupporting

confidence: 93%

Mean macular intercapillary area in eyes with diabetic macular oedema after anti‐vascular endothelial growth factor therapy and its association with treatment response

Sorour

Elsheikh

Chen

et al. 2021

Clinical Exper Ophthalmology

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Background: To evaluate the changes in the mean macular intercapillary area (ICA) from sequential enface optical coherence tomography angiography (OCTA) images following intravitreal anti-vascular endothelial growth factor (VEGF) therapy in initially treatment-naïve eyes with diabetic macular oedema (DME). Methods: In this multicentre retrospective study, 6 Â 6 and 3 Â 3 mm customised, total retinal projection enface OCTA images were collected and processed for quantitative assessment of ICA by a customised MATLAB software. Measurements were done in concentric regions centred on the fovea-with the exclusion of foveal avascular zone (FAZ)-in 0.5 mm diameter increments as well as within the intervening rings.Results: In this study, 6 Â 6 mm OCTA images from 46 eyes of 29 patients, and 3 Â 3 mm OCTA images from 23 eyes of 15 patients were included. There was no significant change in mean ICA after treatment in either scan size or in any measurement regions (all p > 0.05). Multivariate analysis revealed that baseline BCVA was significantly correlated with the visual outcome (p = 0.039). Additionally, after correction for age, baseline central retinal thickness (CRT), baseline BCVA, and retinopathy severity, mean ICA in the 1.5 mm An abstract for the initial results of this study was presented at the virtual 38th annual meeting of American Society of retinal specialists on July 2020.

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Section: Discussionsupporting

confidence: 93%

Mean macular intercapillary area in eyes with diabetic macular oedema after anti‐vascular endothelial growth factor therapy and its association with treatment response

Sorour

Elsheikh

Chen

et al. 2021

Clinical Exper Ophthalmology

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“…Enlargement of FAZ due to capillary nonperfusion is associated with significant visual loss in patients with diabetic retinopathy [14][15][16], and has shown to be a prognostic indicator of disease severity [7,24,47]. Previous histopathological studies of diabetic retina have reported that the frequency of diabetic vascular lesions was significantly higher in the temporal retina than in the nasal retina [48,49].…”

Section: Within-subject Faz Area Enlargementsmentioning

confidence: 99%

“…A number of studies using intravenous fluorescein angiography (IVFA) or optical coherence tomography (OCT) angiography have utilized the detection of retinal vascular abnormalities and foveal avascular zone (FAZ) enlargement to assess the severity of diabetic retinopathy [5][6][7][8][9][10][11][12][13]. Altered configuration and enlargement of the FAZ has shown strong correlation with poorer visual outcomes and diabetic retinopathy progression [14][15][16], making quantification of FAZ dimensions increasingly important for assessment of clinical severity and predicting prognosis in diabetic retinopathy.…”

Section: Introductionmentioning

confidence: 99%

Within-subject assessment of foveal avascular zone enlargement in different stages of diabetic retinopathy using en face OCT reflectance and OCT angiography

Lynch¹,

Romo²,

Linderman³

et al. 2018

Biomed. Opt. Express

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Enlargement of the foveal avascular zone (FAZ) due to progressive capillary nonperfusion is associated with visual deterioration in patients with diabetic retinopathy. The FAZ area has long been considered an important clinical marker of advancing retinopathy. However, a large body of literature shows that the FAZ area varies considerably in healthy eyes, resulting in substantial overlap between controls and diabetics, thus reducing its discriminatory value. In this study, within-subject FAZ area enlargement was obtained by the comparison of the structural FAZ area to the functional FAZ area using simultaneouslyacquired, corresponding en face OCT reflectance and OCT angiography images. Our study suggests that en face OCT reflectance images provide useful anatomic baselines of structural FAZ morphology prior to the onset of disease. Measurements of within-subject FAZ area enlargement appear to be a more sensitive method for identifying the onset of diabetic retinopathy as compared to using OCT angiographic measurements of FAZ alone.

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“…Reconstruction of multiple macular B-scans by powerful computer processors can, therefore, provide us with noninvasive en-face OCT scans of retinal and choroidal layers of various depths, which can help in the understanding of various retinal conditions. 7–10…”

Section: Introductionmentioning

confidence: 99%

En-face choroidal vascularity in central serous chorioretinopathy

Wong

Singh

Rasheed

et al. 2020

European Journal of Ophthalmology

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Purpose: To evaluate the choroidal vascularity index of eyes for acute and chronic central serous chorioretinopathy patients using swept-source optical coherence tomography generated en-face scans. Methods: This was a retrospective study, in which slabs of en-face optical coherence tomography scans, at 5 μm intervals, spanning from the retina to choroid, were binarized using a validated algorithm to calculate choroidal vascularity index. The choroidal vascularity index was defined as the ratio between the choroidal vascular luminal area and the total choroidal area. Choroidal vascularity index was calculated for all the slabs of every subject in both the groups. Results: A total of 30 eyes for each acute and chronic central serous chorioretinopathy groups were recruited. The mean choroidal vascularity index of the acute group was 45.21% ± 2.25% at the choriocapillaris, which increased to the maximal value of 48.35% ± 2.06% at 75% depth of the choroidal thickness and 45.31% ± 3.27% at the choroidoscleral interface; whereas for the chronic group, the mean choroidal vascularity index was 44.76% ± 2.60% at the choriocapillaris, which maximized at 50% choroidal depth (48.70% ± 1.32%) and then returned to 45.41% ± 6.02% at the choroidoscleral interface. Conclusion: For both groups, the choroidal vascularity index increased from choriocapillaris to maximum values at mid-choroid and returned to almost the choriocapillaris value at the choroidoscleral interface.

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Relationship of intercapillary area with visual acuity in diabetes mellitus: an optical coherence tomography angiography study

Cited by 22 publications

References 28 publications

Mean macular intercapillary area in eyes with diabetic macular oedema after anti‐vascular endothelial growth factor therapy and its association with treatment response

Mean macular intercapillary area in eyes with diabetic macular oedema after anti‐vascular endothelial growth factor therapy and its association with treatment response

Within-subject assessment of foveal avascular zone enlargement in different stages of diabetic retinopathy using en face OCT reflectance and OCT angiography

En-face choroidal vascularity in central serous chorioretinopathy

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