Relationship of Isolated Single Umbilical Artery to Fetal Growth, Aneuploidy, and Perinatal Mortality

Abstract

The umbilical cord normally contains 2 arteries and a single vein. When an umbilical artery is absent, the condition is called single umbilical artery (SUA). The reported prevalence of SUA varies from 0.5% at the second-trimester prenatal Fetal Diagnosis and Therapy 193 ABSTRACT Among the countries in the Organization for Economic Cooperation and Development, the United States ranks first in health care spending but 25th in spending on social services. High spending on health care may result from low spending on social services. Safe housing, healthful food, and opportunities for education and employment have critical impacts on health. Lack of investment in social determinants of health probably contributes to the high spending on medical care in the United States, which is well behind other countries on basic indicators of population health. This is especially true for homelessness and housing.If homeless people can be provided supportive housing, that is, affordable housing coupled with supportive services, such as on-site case management and referrals to community-based services, health can be improved, hospital use can be Ethics, Medicolegal Issues, and Public Policy

Congenital heart disease and adverse perinatal outcome in fetuses with confirmed isolated single functioning umbilical artery

“…However, Predanic et al (2005) did not fi nd any statistical diff erence between fetuses with SUA and fetuses with a 3-vessel umbilical cord for the incidence of small-for-gestational age newborns. In a recent systematic review and meta-analysis, Voskamp et al (2013) did not fi nd any association between isolated SUA and FGR/perinatal mortality.…”

“…However, Predanic et al (2005) have not found any diff erence in the incidence of smallfor-gestational age newborns between fetuses with isolated SUA and those with a 3-vessel umbilical cord. In a recent systematic review and meta-analysis, Voskamp et al (2013) did not fi nd statistical diff erences between fetuses with isolated SUA and fetuses with a 3-vessel umbilical cord in relation to outcome measures for small-for-gestational age, perinatal mortality and aneuploidy.…”

Prenatal evaluation of chromosomal abnormalities and copy number variations in fetuses with single umbilical artery

“…This supported the use of the CNV-seq in prenatal genetic diagnosis for isolated SUA and presented the underlying genetic etiology for isolated SUA. Studies have shown that isolated SUA is an independent risk factor for fetal IUGR, SGA, and extreme preterm birth [3,20]. Some have suggested an increased prevalence of renal anomalies among fetuses in whom isolated SUA, it is possible that these anomalies contribute to an increased incidence of children's urinary system infections [4] Therefore, CNV-seq can provide additional clinically relevant information when the karyotype is normal in fetuses with SUA and will able them to decide upon the appropriate reproductive options, providing bene t to both the patients and their families.…”