Relationship of leptin, postprandial glucose level and hemodynamics in hypertensive obese patients

Molchanova, O. V; Bystrova, M. M.; Britov, A. N.

doi:10.1016/s0895-7061(03)00698-8

Cited by 2 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, after this adjustment, the associations between leptin and SV, CO and C W disappeared, but a negative association with DBP became apparent and the negative association with TPR remained. These results were confirmed by means of multiple regression analyses (Table 3 What is known about leptin and cardiovascular function (a) Leptin correlates with body fat mass and is invariably elevated in obese compared to lean subjects 6 (b) Leptin has been found to be positively associated with blood pressure in various population groups [8][9][10][11][12][13] (c) Leptin is independently associated with systolic blood pressure, pulse pressure and arterial compliance in obese hypertensive African women 21 (d) Leptin has pressor effects by: K Decreasing vascular function 14 Leptin is independently associated with intima media thickness of the common carotid artery 15 and decreased arterial distensibility, decreasing arterial compliance 14 This is possible since leptin receptors are situated on the endothelium 35 and vascular smooth muscle cells 36 K Increasing renal sympathetic activity:…”

Section: Discussionmentioning

confidence: 73%

“…5 Since the adipocyte derived hormone, leptin, is invariably elevated in the obese, 6 studies have suggested the involvement of leptin in obesityrelated hypertension. 7 Rightly so, leptin has pressor actions and has been associated with blood pressure [8][9][10][11][12][13] as well as decreased vascular function, 14,15 lowering C W and increasing TPR. Furthermore, leptin also activates the sympathetic nervous system.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Leptin is favourably associated with vascular function in obese Caucasians, but not in obese Africans

et al. 2005

View full text Add to dashboard Cite

The comparison of the associations between chronically elevated leptin levels and cardiovascular function in obese Africans and Caucasians has not yet been determined. Therefore, the aim of this study was to compare leptin's associations with cardiovascular function in obese African and obese Caucasian women to determine whether leptin's associations differ between these two groups. This study consisted of two casecase control studies. The first study included a sample of 102 apparently healthy African women and the second, 115 apparently healthy Caucasian women. All lean and obese subjects were selected from each study. The Finometer apparatus was used to obtain a more elaborate cardiovascular profile. Serum leptin levels, insulin levels and the lipid profile were determined. Stroke volume (SV) and cardiac output (CO) were significantly (Pp0.01) elevated in both obese African and Caucasian groups compared to their lean controls.Total peripheral resistance (TPR) was significantly decreased and arterial compliance (C W ) significantly increased in both obese African and Caucasian groups. In the obese Caucasian group, diastolic blood pressure (DBP) was significantly (Pp0.01) lower, SV and C W significantly higher (Pp0.01) and TPR significantly lower compared to the age, body mass index (BMI), and leptin-matched obese African group. After adjusting for age and BMI, leptin correlated negatively with DBP (Pp0.05; r ¼ À0.33) and TPR (Pp0.05; r ¼ À0.36) in the obese Caucasian group, but not in the obese African group. Even though leptin levels were similar in obese African and Caucasian women, leptin is favourably associated with vascular function in obese Caucasians, but not in obese Africans.

show abstract

Section: Discussionmentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Leptin is favourably associated with vascular function in obese Caucasians, but not in obese Africans

et al. 2005

View full text Add to dashboard Cite

show abstract

“…Leptin levels have been reported to be higher in patients with hypertension compared to normotensive controls 11,43 and have been positively associated with blood pressure in various nonAfrican population groups. [10][11][12][13][14][15]43 El-Gharbawy et al 8 failed to obtain a direct positive association between leptin and blood pressure in obese hypertensive African-American women with leptin levels that were significantly higher in relation to a obese normotensive African-American female group. Since leptin is independently associated with intima-media thickness, 17 decreased arterial distensibility 16 (decreasing arterial compliance) and blood pressure [10][11][12][13][14][15]43 in non-African population groups, the findings by El-Gharbawy et al 8 seems surprising since the group under study was hyperleptinaemic and hypertensive.…”

Section: Discussionmentioning

confidence: 99%

“…8 Evidence suggests that elevated leptin levels may play an important role in the pathogenesis of obesity-related hypertension 9 and accordingly has been associated with increased blood pressure. [10][11][12][13][14][15] The mechanisms associating leptin with blood pressure in obesityrelated hypertension are multiple. One mechanism has been the involvement of leptin in decreasing vascular function.…”

Section: Introductionmentioning

confidence: 99%

Leptin is independently associated with systolic blood pressure, pulse pressure and arterial compliance in hypertensive African women with increased adiposity: the POWIRS study

et al. 2005

View full text Add to dashboard Cite

High leptin levels are often observed in human obesity and are implicated in obesity-related hypertension. Leptin levels have been found to be higher in hypertensive obese African-American women compared to normotensive African-American women, but a direct association between leptin and blood pressure could not be obtained. Additionally, increased adiposity has been associated with higher aortic stiffness in obese African-American women, but leptin was not included in the study. The effects of leptin on cardiovascular function in African women have not yet been determined. We hypothesised that leptin is directly associated with blood pressure and decreased arterial compliance and that leptin levels are significantly higher in hypertensive overweight/obese African women compared to normotensive overweight/obese African women. A case-case control study was performed which included 98 African women. The subjects were divided into lean normotensive (lean NT), overweight/obese normotensive (OW/OB NT) and overweight/obese hypertensive (OW/OB HT). The Finometer apparatus was used to obtain a more elaborate cardiovascular profile. Serum leptin and insulin levels as well as the HOMA-IR index were determined. Various anthropometric measures were obtained. Leptin levels were elevated (Pp0.05) in the OW/OB NT and HT groups compared to the lean NT group, but were similar in the OW/OB NT and HT groups. After adjusting for obesity, insulin resistance, hyperinsulinaemia and age, a direct positive correlation was obtained between leptin and systolic blood pressure (SBP) (Pp0.05; r ¼ 0.68) in the OW/OB HT group. Additionally, leptin also correlated negatively with arterial compliance (Pp0.05; r ¼ À0.76) and positively with pulse pressure (Pp0.05; r ¼ 0.71) in the OW/OB HT group. In conclusion, even though leptin levels were the same in OW/OB HT and NT African women, leptin was directly and positively associated with SBP and pulse pressure and negatively with C W only in OW/OB HT African women, independent of obesity, insulin-resistance, hyperinsulinaemia and age.

show abstract

Relationship of leptin, postprandial glucose level and hemodynamics in hypertensive obese patients

Cited by 2 publications

References 0 publications

Leptin is favourably associated with vascular function in obese Caucasians, but not in obese Africans

Leptin is favourably associated with vascular function in obese Caucasians, but not in obese Africans

Leptin is independently associated with systolic blood pressure, pulse pressure and arterial compliance in hypertensive African women with increased adiposity: the POWIRS study

Contact Info

Product

Resources

About