Relationship of lifestyle, exercise, and nutrition with glaucoma

Pérez, Carolina Alejandra; Singh, Kuldev; Lin, Shan

doi:10.1097/icu.0000000000000553

Cited by 60 publications

(47 citation statements)

References 57 publications

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“…In summary, the results from our in vivo investigations revealed that oral intake of GTE is safe and can ameliorate ischemia-induced RGC degeneration and suppress RGC function impairment in rats through the alleviation of cell apoptosis, oxidative stress, and inflammation. Since GTE shows a better protective effect than EGCG in our previous retinal degeneration model [14] and green tea catechins can be found within hours after GTE oral administration [15], this study further supports that GTE can serve as a potent therapeutic agent to RGC degeneration and support the report that tea consumption could possibly be protective against glaucoma development [29].…”

Section: Discussionsupporting

confidence: 83%

Green Tea Extract Ameliorates Ischemia-Induced Retinal Ganglion Cell Degeneration in Rats

Yang

Chen

et al. 2019

Oxidative Medicine and Cellular Longevity

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Purpose. Oxidative stress induced by reduced blood circulation is a critical pathological damage to retinal ganglion cells (RGCs) in glaucoma. We previously showed that green tea extract (GTE) and its catechin constituents alleviate sodium iodate-induced retinal degeneration in rats. Here, we investigated the therapeutic effect of GTE on ischemia-induced RGC degeneration in rats. Methods. RGC degeneration was induced by ischemic reperfusion in adult Fischer F344 rats. Green tea extract (Theaphenon E) was intragastrically administered 4 times within 48 hours after ischemia. RGC survival, pupillary light reflex, expressions of cell apoptosis, oxidative stress, and inflammation-related proteins were studied. Results. Ischemic reperfusion significantly induced apoptotic RGCs, RGC loss, and larger constricted pupil area compared to the untreated normal rats. Expressions of activated caspase-3 and caspase-8, Sod2, and inflammation-related proteins as well as p38 phosphorylation were significantly upregulated in the ischemia-injured rats. Compared to the saline-fed ischemic rats, significantly higher number of surviving RGCs, less apoptotic RGCs, and smaller constricted pupil area were observed in the GTE-fed ischemic rats. GTE also reduced the increased protein expressions caused by ischemic injury but enhanced the Jak phosphorylation in the retina. Notably, green tea extract did not affect the survival of RGCs in the uninjured normal rats. Conclusions. In summary, GTE offers neuroprotection to RGCs under ischemic challenge, suggesting a potential therapeutic strategy for glaucoma and optic neuropathies.

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Section: Discussionsupporting

confidence: 83%

Green Tea Extract Ameliorates Ischemia-Induced Retinal Ganglion Cell Degeneration in Rats

Yang

Chen

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…There are several approaches for preventing the risk of PM 2.5 via reduction of outdoor and indoor exposure, using air cleaners and air filtration masks [56]. Regular physical exercises, eating more vegetables, improvement in the quality of life, and upregulation of the connection of the nervous system all reduce the risk of glaucoma [57].…”

Section: Discussionmentioning

confidence: 99%

Association Between PM2.5 Exposure Level and Primary Open-Angle Glaucoma in Taiwanese Adults: A Nested Case–control Study

Sun

Luo

Chiang

et al. 2021

IJERPH

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Primary open-angle glaucoma (POAG) is the most common type of glaucoma. However, little is known about POAG in adults and exposure to air pollution. The current study aims to investigate whether exposure to particulate matter with a mass median aerodynamic diameter of ≤2.5 μm (PM2.5) is associated with POAG diagnosis. Patient data were obtained from the Longitudinal Health Insurance Database 2010 (LHID2010) of Taiwan for the 2008–2013 period. PM2.5 concentration data, collected from the Ambient Air Quality Monitoring Network established by the Environmental Protection Administration of Taiwan, were categorized into four groups according to World Health Organization (WHO) exposure standards for PM2.5. We estimated the odds ratios (ORs) and 95% CIs for risk factors for POAG with logistic regression. The OR of per WHO standard level increase was 1.193 (95% CI 1.050–1.356). Compared with the normal level, the OR of WHO 2.0 level was 1.668 (95% CI 1.045–2.663, P < 0.05). After excluding confounding risk factors for POAG in this study, we determined that increased PM2.5 exposure is related to POAG risk (ORs > 1, P < 0.05). In this study, PM2.5 was an independent factor associated with open-angle glaucoma. Further research is required to better understand the mechanisms connecting PM2.5 and open-angle glaucoma.

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“…Previous studies have suggested that some local factors, such as resistance of the trabecular meshwork and juxtacanalicular connective tissues, are the major determinants of IOP [3,4]. However, the exogenous effects on the glaucoma [5,6] or IOP [7] by various systemic factors, lifestyle, and diet also have been suggested recently to be contributors.…”

Section: Introductionmentioning

confidence: 99%

Systemic factors associated with intraocular pressure among subjects in a health examination program in Japan

et al. 2020

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Background To elucidate the possible effect of various systemic factors on intraocular pressure (IOP) using a dataset from a health examination program database in Japan. Methods This cross-sectional study included 1569 subjects selected from the 2287 subjects who comprised the database. Various systemic parameters including age, sex, height, body weight, waist circumference, percent body fat, blood pressure (BP), pulse rate, body mass index, 28 blood examination values, intimal medial thicknesses of both carotid arteries, and intraocular pressure (IOP) values measured by non-contact tonometry in both eyes were collected. The possible correlation between the IOP and other parameters was assessed initially by univariate analyses followed by multivariate analyses. Results Stepwise multivariate analyses, which included all parameters extracted by the univariate analyses (p<0.1) and sex, identified the same six parameters as indicators of the IOP values for each right and left IOP model. Among the parameters, age (r =-0.05 and-0.04/year for right and left IOPs, respectively) was associated negatively and the percent body fat (r = 0.06 and 0.05/%), systolic BP (r = 0.02 and 0.03/mmHg), pulse rate (r = 0.03 and 0.03/ counts/minutes), albumin (r = 1.12 and 1.00/g/dL), and hemoglobin A1c (r = 0.38 and 0.44/ %) were associated positively with the IOP in each eye. Conclusions Older age was associated with low IOP, while factors reflecting the metabolic syndrome were associated with high IOP in our study population.

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Relationship of lifestyle, exercise, and nutrition with glaucoma

Cited by 60 publications

References 57 publications

Green Tea Extract Ameliorates Ischemia-Induced Retinal Ganglion Cell Degeneration in Rats

Green Tea Extract Ameliorates Ischemia-Induced Retinal Ganglion Cell Degeneration in Rats

Association Between PM2.5 Exposure Level and Primary Open-Angle Glaucoma in Taiwanese Adults: A Nested Case–control Study

Systemic factors associated with intraocular pressure among subjects in a health examination program in Japan

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