Relationship of lipoprotein-associated phospholipase A2(Lp-PLA2) and periprocedural myocardial injury in patients undergoing elective percutaneous coronary intervention

Yin, Yun-jie; Chen, Yan-Chun; Xu, Lei; Zhao, Xianxian; Yang, Song

doi:10.1016/j.ijcha.2020.100541

Cited by 4 publications

(1 citation statement)

References 23 publications

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“…It has been shown to be an independent risk marker for coronary artery disease after adjusting for lipid, inflammatory and hemostatic parameters (29). More recently, it was demonstrated that preprocedural levels of Lp-PLA2 in patients undergoing elective PCI independently predicted periprocedural myocardial injury (30). Shah et al have recently demonstrated in their prospective study of >4000 patients (all-comers) that baseline WBC remains an independent predictor of MACE and importantly target lesion revascularisation (TLR) as well, in the modern era of DES and pharmacotherapy.…”

Section: Drug Eluting Stents (Des)mentioning

confidence: 99%

The role of inflammation in percutaneous coronary intervention, from balloon angioplasty to drug eluting stents

Merinopoulos¹,

Gunawardena²,

Corballis³

et al. 2023

Minerva Cardiol Angiol

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The role of inflammation in percutaneous coronary intervention (PCI) has been investigated in numerous studies. Both pre-PCI and post-PCI inflammatory status have been demonstrated to be linked with patient outcomes. C-reactive protein (CRP) continues to be the most studied inflammatory biomarker, while a growing number of additional biomarkers, including cytokines and immune cells, are being assessed. As insights are gained into the complexities of the inflammatory response to PCI, it becomes evident that a targeted approach is necessary to ensure optimal patient outcomes. Here, we review the biomarkers that can predict patient outcomes following PCI and specifically how they differ for balloon angioplasty, bare metal stents and drug eluting stents. A specific focus is given to human studies and peri-procedural inflammation rather than inflammation associated with myocardial infarction.

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Section: Drug Eluting Stents (Des)mentioning

confidence: 99%

The role of inflammation in percutaneous coronary intervention, from balloon angioplasty to drug eluting stents

Merinopoulos¹,

Gunawardena²,

Corballis³

et al. 2023

Minerva Cardiol Angiol

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Lipoprotein-associated phospholipase A2 and coronary artery disease

Bari,

Krishnan,

Babu

2023

Phospholipases in Physiology and Pathology

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The Relationship Between Lipoprotein-Associated Phospholipase-A2 and Coronary Artery Aneurysm in Children With Kawasaki Disease

et al. 2022

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BackgroundCoronary artery lesions including aneurysm, as the most severe complications of Kawasaki disease (KD), remain of great concern. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is implicated in the regulation of inflammatory response and lipid metabolism. Since excessive inflammatory response and aberrant lipid metabolism have involved in the development of KD, we in this study sought to investigate the relationship between coronary artery aneurysm (CAA) and Lp-PLA2 and other blood parameters in children with KD.MethodsThe participants included 71 KD patients, 63 healthy controls (HCs) and 51 febrile controls (FCs). KD patients were divided into KD-CAA (KD with CAA) group and KD-NCAA (KD without CAA) group. Serum Lp-PLA2 levels were measured using enzyme-linked immunosorbent assays. Other routine clinical parameters were also detected.ResultsSerum Lp-PLA2 levels in KD group [4.83 μg/mL (3.95–6.77)] were significantly higher than those in HC [1.29 μg/mL (0.95–2.05)] and FC [1.74 μg/mL (1.18–2.74)] groups. KD-CAA group [5.56 μg/mL (4.55–22.01)] presented substantially higher serum Lp-PLA2 levels as compared with KD-NCAA group [4.64 μg/mL (2.60–5.55)]. In KD group, serum Lp-PLA2 level was positively related with erythrocyte sedimentation rate, the levels of leukocytes, platelets, albumin, creatine kinase-MB, and D-dimer, and the Z-scores of left main CA, right CA, left anterior descending CA, and left circumflex CA; and negatively related with mean corpuscular hemoglobin concentration and mean platelet volume. Moreover, receiver operating characteristic curves showed that Lp-PLA2 exhibited superior and moderate diagnostic performance for distinguishing KD patients from HC and FC ones, respectively, and possessed the potential ability to predict the occurrence of CAAs in KD.ConclusionLp-PLA2 may be related to KD and the formation of CAAs, and thus may serve as a potential diagnostic biomarker for KD.

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Relationship of lipoprotein-associated phospholipase A2(Lp-PLA2) and periprocedural myocardial injury in patients undergoing elective percutaneous coronary intervention

Cited by 4 publications

References 23 publications

The role of inflammation in percutaneous coronary intervention, from balloon angioplasty to drug eluting stents

The role of inflammation in percutaneous coronary intervention, from balloon angioplasty to drug eluting stents

Lipoprotein-associated phospholipase A2 and coronary artery disease

The Relationship Between Lipoprotein-Associated Phospholipase-A2 and Coronary Artery Aneurysm in Children With Kawasaki Disease

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