Relationship of Liver Blood Tests and T1 Relaxation Time With Intra-pancreatic Fat Deposition

Shamaitijiang, Xiatiguli; Kimita, Wandia; Ko, Juyeon; Skudder-Hill, Loren; Liu, Yutong; Petrov, Maxim S.

doi:10.1016/j.jceh.2023.101343

Journal of Clinical and Experimental Hepatology

2024

DOI: 10.1016/j.jceh.2023.101343

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Relationship of Liver Blood Tests and T1 Relaxation Time With Intra-pancreatic Fat Deposition

Xiatiguli Shamaitijiang,

Wandia Kimita,

Juyeon Ko

et al.

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2024

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Cited by 2 publications

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The moderating effect of cardiometabolic factors on the association between hepatic and intrapancreatic fat

Skudder‐Hill,

Sequeira‐Bisson,

et al. 2024

Obesity

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ObjectivePrevious studies have investigated the association between hepatic fat and intrapancreatic fat deposition (IPFD); however, results have been inconclusive. The presence of cardiometabolic factors in certain subpopulations could explain this discrepancy. The aim of the present study was to use moderation analyses to determine the conditions under which hepatic fat is associated with IPFD.MethodsAll participants underwent 3T abdominal magnetic resonance imaging (MRI) and spectroscopy. Hepatic fat and IPFD were manually quantified by independent raters. Moderation analyses were performed with adjustment for sex and ethnicity.ResultsThere were 367 participants included. Adjusted analyses of the overall cohort revealed that age, glycated hemoglobin (HbA1c), low‐density lipoprotein cholesterol (LDL‐C), high‐density lipoprotein cholesterol (HDL‐C), and triglycerides were significant moderators (p < 0.05) of the association between hepatic fat and IPFD. Ranges of significance included age < 61 years, HbA1c < 45 mmol/mol, LDL‐C < 157 mg/dL, HDL‐C > 36 mg/dL, and triglycerides < 203 mg/dL.ConclusionsThe association between hepatic fat and IPFD is generally present in young and middle‐aged adults with good cardiometabolic health, whereas the link between the two fat depots becomes uncoupled in older adults or individuals with cardiometabolic risk factors.image

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The moderating effect of cardiometabolic factors on the association between hepatic and intrapancreatic fat

Skudder‐Hill,

Sequeira‐Bisson,

et al. 2024

Obesity

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Relationship of high‐density lipoprotein subfractions and apolipoprotein A‐I with fat in the pancreas

Liu,

Shamaitijiang,

Skudder‐Hill

et al. 2024

Diabetes Obesity Metabolism

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AimTo investigate the associations of high‐density lipoprotein (HDL) subfractions and apolipoprotein A‐I (apo A‐I) with fat in the pancreas.MethodsA total of 170 individuals were studied. All participants underwent magnetic resonance imaging on a single 3.0‐Tesla scanner to determine the presence/absence of fatty pancreas. HDL subfractions were measured using a commercially available lipoprotein subfractions testing system and classed as large, intermediate and small HDL. Both unadjusted and adjusted (accounting for demographics, anthropometrics, insulin resistance and other covariates) logistic regression models were built.ResultsIndividuals with fatty pancreas had significantly lower circulating levels of the large HDL class and apo A‐I. Every unit decrease in the large HDL class was associated with a 93% increase in the likelihood of fatty pancreas in the most adjusted model (P < .001). Every unit decrease in apo A‐I was associated with a 45% increase in the likelihood of fatty pancreas in the most adjusted model (P = .012). The intermediate and small HDL classes were not significantly associated with fatty pancreas.ConclusionsFat in the pancreas is inversely associated with the circulating levels of large HDL particles and apo A‐I. Purposely designed studies are warranted to investigate the potential of fatty pancreas as an indicator of the risk of cardiovascular diseases.

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Relationship of Liver Blood Tests and T1 Relaxation Time With Intra-pancreatic Fat Deposition

Cited by 2 publications

References 64 publications

The moderating effect of cardiometabolic factors on the association between hepatic and intrapancreatic fat

The moderating effect of cardiometabolic factors on the association between hepatic and intrapancreatic fat

Relationship of high‐density lipoprotein subfractions and apolipoprotein A‐I with fat in the pancreas

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