Relationship of lumbar disc degeneration with hemoglobin value and smoking

Kiraz, Murat; Demir, Emre

doi:10.1016/j.neuchi.2020.06.133

Cited by 17 publications

(11 citation statements)

References 41 publications

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“…Smoking is also responsible for a considerable proportion of deaths due to any cause [ 4 ]. Smoking is positively associated with lumbar disc degeneration [ 5 ] and osteoporosis [ 6 ]. Since lumbar disc generation and vertebral fracture, which is strongly related to osteoporosis [ 7 ], are known major risk factors for height loss among adults, smoking could affect height loss in the general population.…”

Section: Introductionmentioning

confidence: 99%

Association between smoking and height loss in Japanese workers: A retrospective study

Shimizu,

Sasaki,

Hayakawa

et al. 2024

PLoS ONE

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Height loss is reported to be an independent risk factor for all-cause and cardiovascular mortality. Smoking, which is responsible for a considerable proportion of deaths due to any cause, is also associated with lumbar disc degeneration, a major risk factor for height loss. Therefore, smoking could be an independent risk factor for height loss. To clarify the association between smoking status and height loss, a retrospective study with 8,984 (5,518 men and 3,466 women) Japanese workers was conducted. The present study population comprised 9,681 workers aged 40–74 years who participated in annual medical examinations between 2011 and 2017 (baseline). Subjects without a height measurement during 2012–2018 (endpoint) were excluded from the analysis (n = 697). Height loss was defined as being in the highest quartile of annul height decrease (1.48 mm/year for men and 1.79 mm/year for women). Independent of known cardiovascular risk factors, smoking was positively associated with height loss among men but not among women. With never smokers as the referent group, the adjusted odds ratio (95% confidence interval) was 1.15 (0.98, 1.35) for former smokers and 1.24 (1.05, 1.46) for current smokers among men, respectively. Among women, the corresponding values were 0.98 (0.79, 1.21) and 0.90 (0.71, 1.16), respectively. Since height loss and smoking are independent risk factors for all-cause and cardiovascular mortality, these results help clarify the mechanisms underlying the association between height loss and mortality risk.

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Section: Introductionmentioning

confidence: 99%

Association between smoking and height loss in Japanese workers: A retrospective study

Shimizu,

Sasaki,

Hayakawa

et al. 2024

PLoS ONE

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“…Regarding smoking, intervertebral disc cells experience disruption to their normal metabolic activities when exposed directly to soluble smoking gene toxin, which can disseminate through the vascular system or vertebral endplate (26). Several studies have shown that smoking is a key factor causing sciatica, LBP, and intervertebral disc degeneration and has a significant dose-dependent relationship with smoking (27)(28)(29)(30). Furthermore, Shady et al also demonstrated two mechanisms of nicotine-induced disc herniation using the finite-element method: nicotine-mediated downregulation of cell proliferation and anabolism and reduction of blood flow of blood vessels around the intervertebral disc due to vasoconstriction (31).…”

Section: Discussionmentioning

confidence: 99%

Risk factors for lumbar disc herniation in adolescents and young adults: A case–control study

Luo

Meng

et al. 2023

Front. Surg.

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BackgroundThere is a limited understanding of the risk factors for lumbar disc herniation (LDH) in younger people, even though the evidence suggests that LDH is more prevalent in this population. This study aimed to comprehensively analyze the risk factors for LDH in adolescents and young adults.MethodsThe medical records of all patients were retrospectively reviewed with inclusion criteria of being younger than 25 years. Magnetic resonance imaging (MRI) was used to confirm LDH from September 2016 to September 2021. Furthermore, 104 healthy people in the same age range were enrolled as the control group from physical examination centers. Gender, BMI, smoking, drinking, genetic history, sitting posture, daily sitting time, traumatic history of the lower back, scoliosis, and daily exercise time were examined for all enrolled people. These factors were statistically analyzed to determine the high-risk factors.ResultsA total of 208 young individuals were enrolled in the present study. The mean age of the study group and the control group was 21.06 ± 3.27 years (range: 11–25 years) and 21.26 ± 2.23 years (range: 15–25 years), respectively. The result of the chi-squared test demonstrated that there was a significant difference in BMI of more than 30 (p < 0.001), genetic history (p = 0.004), sitting posture (p < 0.001), daily sitting time of more than 6 h (p < 0.001), and the history of low back trauma (p = 0.002). Additionally, multivariate logistic regression showed that these were high-risk factors for LDH, particularly the duration of daily sitting time (more than 6 h).ConclusionsBMI of more than 30, genetic history, sitting posture, daily sitting time of more than 6 h, and a history of low back trauma are the high-risk factors for adolescents and young adults with LDH. Therefore, providing them with the proper guidance and education, particularly about the protection of the lower back and the reduction of spinal load, could play a key role in preventing and reducing LDH.

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“…IVDD is a common spine disease associated with many risk factors, such as genetic susceptibility ( 7 ), mechanical stress ( 8 ), trauma ( 9 ), heavy workload ( 10 ), smoking ( 11 ), obesity ( 12 ), and aging ( 13 ) that may result in the occurrence of IVDD. Previous studies have suggested that a lot of pathological processes including ECM degradation ( 14 ), systemic inflammation ( 15 ), oxidative stress ( 16 ), mitochondrial dysfunction ( 17 ), telomere shortening ( 18 ) and DNA damage ( 19 ), nutritional deprivation ( 20 ), abnormal mechanical load ( 21 ), and epigenetic changes ( 22 ) may lead to IVDD.…”

Section: Discussionmentioning

confidence: 99%

Identification of a potential novel biomarker in intervertebral disk degeneration by bioinformatics analysis and experimental validation

Yang

Yuan

2023

Front. Immunol.

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BackgroundIntervertebral disk degeneration (IVDD) is a major cause of low back pain and one of the most common health problems all over the world. However, the early diagnosis of IVDD is still restricted. The purpose of this study is to identify and validate the key characteristic gene of IVDD and analyze its correlation with immune cell infiltration.Methods3 IVDD-related gene expression profiles were downloaded from the Gene Expression Omnibus database to screen for differentially expressed genes (DEGs). Gene Ontology (GO) and gene set enrichment analysis (GSEA) were conducted to explore the biological functions. Two machine learning algorithms were used to identify characteristic genes, which were tested to further find the key characteristic gene. The receiver operating characteristic curve was performed to estimate the clinical diagnostic value of the key characteristic gene. The excised human intervertebral disks were obtained, and the normal nucleus pulposus (NP) and degenerative NP were carefully separated and cultured in vitro. The expression of the key characteristic gene was validated by real-time quantitative PCR (qRT-PCR). The related protein expression in NP cells was detected by Western blot. Finally, the correlation was investigated between the key characteristic gene and immune cell infiltration.ResultsA total of 5 DEGs, including 3 upregulated genes and 2 downregulated genes, were screened between IVDD and control samples. GO enrichment analysis showed that DEGs were enriched to 4 items in BP, 6 items in CC, and 13 items in MF. They mainly included the regulation of ion transmembrane transport, transporter complex, and channel activity. GSEA suggested that the cell cycle, DNA replication, graft versus host disease, and nucleotide excision repair were enriched in control samples, while complement and coagulation cascades, Fc γ R–mediated phagocytosis, neuroactive ligand–receptor interaction, the NOD-like receptor signaling pathway, gap junctions, etc., were enriched in IVDD samples. Furthermore, ZNF542P was identified and tested as key characteristic gene in IVDD samples through machine learning algorithms and showed a good diagnostic value. The results of qRT-PCR showed that compared with normal NP cells, the expression of ZNF542P gene was decreased in degenerated NP cells. The results of Western blot suggested that compared with normal NP cells, the expression of NLRP3 and pro Caspase-1 was increased in degenerated NP cells. Finally, we found that the expression of ZNF542P was positively related to the proportions of T cells gamma delta (γδT cells).ConclusionZNF542P is a potential biomarker in the early diagnosis of IVDD and may be associated with the NOD-like receptor signaling pathway and the infiltration of γδT cells.

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Relationship of lumbar disc degeneration with hemoglobin value and smoking

Cited by 17 publications

References 41 publications

Association between smoking and height loss in Japanese workers: A retrospective study

Association between smoking and height loss in Japanese workers: A retrospective study

Risk factors for lumbar disc herniation in adolescents and young adults: A case–control study

Identification of a potential novel biomarker in intervertebral disk degeneration by bioinformatics analysis and experimental validation

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