Relationship of Lutein and Zeaxanthin Levels to Neurocognitive Functioning: An fMRI Study of Older Adults

Lindbergh, Cutter A.; Mewborn, Catherine M; Hammond, Billy R.; Renzi-Hammond, Lisa; Curran‐Celentano, Joanne; Miller, L. Stephen

doi:10.1017/s1355617716000850

Cited by 45 publications

(48 citation statements)

References 82 publications

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“…Many of the recent findings surrounding lutein and neuroefficiency are rooted in studies utilizing the fMRI technique to assess efficiency using blood‐oxygen‐level‐dependent (BOLD) signaling. Colleagues Lindergh et al and Mewborn et al have demonstrated efficiency in the spatial dimension, noting increased efficiency in older adults in tasks of both verbal learning and visual‐spatial processing, respectively . Relying on the BOLD signal allows for unmatched spatial resolution, and provides invaluable information on the regions of the brain recruited to complete a task.…”

Section: Discussionmentioning

confidence: 99%

Macular Xanthophylls and Event‐Related Brain Potentials among Overweight Adults and Those with Obesity

Edwards

Walk

Cannavale

et al. 2019

Molecular Nutrition Food Res

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Scope Macular accumulation of xanthophyll carotenoids (lutein, zeaxanthin) is known to have neuroprotective potential, yet their influence on cognition among overweight adults and those with obesity remains limited. This study examines the impact of macular xanthophylls on attentional resource allocation and information processing speed among adults with BMI ≥ 25 kg m−2. Methods and Results Adults between 25 and 45 years (N = 101) complete heterochromatic flicker photometry to determine macular pigment optical density (MPOD). Event‐related brain potentials are recorded during a visual oddball task. Amplitude and latency of the N2 and P3 indexed attentional resource allocation and information processing speed. Covariates included age, sex, education, intelligence quotient (IQ), %Fat (DXA), and dietary lutein and zeaxanthin (Diet History Questionnaire II). MPOD is inversely related to P3 peak amplitude during standard trials and P3 peak latency during target trials. Therefore, individuals with higher MPOD dedicate fewer attentional resources when attentional demands are low while exhibiting faster information processing speed when attentional demands are increased. Further, MPOD is inversely related to the N2 mean amplitude during targets, signifying greater inhibitory control. Conclusion These findings are the first to link macular xanthophylls to neuroelectric indices of attentional and inhibitory control among adults with overweight and obesity.

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Section: Discussionmentioning

confidence: 99%

Macular Xanthophylls and Event‐Related Brain Potentials among Overweight Adults and Those with Obesity

Edwards

Walk

Cannavale

et al. 2019

Molecular Nutrition Food Res

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“…Their presence in the eye may serve as a protective factor against oxidative damage during early development due to the high metabolic activity of this tissue, abundance of long-chain polyunsaturated fatty acids, and vascularity. Beyond protection, these carotenoids also support neuronal development via stabilizing microtubules [23], enhancing gap junction communication [24], improving vasculature [25], and stabilizing and modifying the permeability of membranes [26].…”

Section: Carotenoidsmentioning

confidence: 99%

“…Nutrients such as fat, including the essential fatty acids, linoleic and alpha-linolenic acids, are an important determinant of energy supply throughout the first year of life and should be well supplied in the diet. Even though a DRI has not been established for carotenoids such as lutein and zeaxanthin, there is a growing body of evidence that these nutrients are important for the development of the visual and neural systems and have a positive impact on health outcomes [20,25].…”

Section: Nutrition For the Growing Child 0-24 Monthsmentioning

confidence: 99%

Nutritional Gaps and Supplementation in the First 1000 Days

Korczak²,

et al. 2019

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Optimized nutrition during the first 1000 days (from conception through the 2nd birthday) is critical for healthy development and a healthy life for the newborn. Pregnancy and the postpartum period are accompanied by physiological changes, increased energy needs, and changing requirements in the nutrients critical for optimal growth and development. Infants and toddlers also experience physiological changes and have specific nutritional needs. Food and nutrition experts can provide women of childbearing age with adequate dietary advice to optimize nutrition, as well as guidance on selecting appropriate dietary supplements. Considering the approaching 2020–2025 Dietary Guidelines for Americans (DGA) will be making specific recommendations for children, it is important to provide accurate scientific information to support health influencers in the field of nutrition. The purpose of this review is to summarize the nutrition and supplementation literature for the first 1000 days; to highlight nutritional and knowledge gaps; and to educate nutrition influencers to provide thoughtful guidance to mothers and families. Optimal nutrition during pregnancy through early childhood is critical for supporting a healthy life. Nutrition influencers, such as dietitians, obstetricians/gynecologists, and other relevant health professionals, should continue guiding supplement and food intake and work closely with expectant families and nutrition gatekeepers.

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“…A number of recent studies have shown that lutein status (i.e., measured in serum/diet and directly in retina, MP) correlates with a number of centrally‐mediated functions including numerous aspects of cognition . In addition, recent imaging studies also suggest a relationship between lutein and CNS functioning …”

Section: Introductionmentioning

confidence: 99%

Dietary Carotenoids Lutein and Zeaxanthin Change Brain Activation in Older Adult Participants: A Randomized, Double‐Masked, Placebo‐Controlled Trial

Ceravolo

Hammond

Oliver

et al. 2019

Molecular Nutrition Food Res

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Scope Steady‐state visual evoked potentials (SSVEP) can be used to test the topological response of cortical neurons. Studies have shown that a lutein (L) preferentially accumulates within cortical tissue. L, zeaxanthin (Z), and their isomers can be measured directly in retina (macular pigment optical density, MPOD), and retinal L+Z correlate highly with L+Z levels in cortical visual processing areas. The purpose of this study was to determine the relation between MPOD and SSVEP signal power, cross‐sectionally and after supplementation with L+Z. Methods and Results SSVEP to three different driving frequencies of stimulation (5, 10, and 16.6 Hz) were obtained for community‐dwelling older adults, at baseline and after 12 months of supplementation with either 12 mg L+Z or placebo. Power was quantified at the driving frequencies. Non‐specific activation was quantified within the 10–15 Hz band. MPOD was measured psychophysically. Subjects with low MPOD had reduced power at 16.6 Hz and reduced non‐specific activation, compared with subjects with high MPOD. Supplementation significantly improved signal power at 5 and 10 Hz. Conclusion Past research suggests that L+Z can improve visual memory, visual processing speeds, etc. One possible mechanism for that improvement may be improving signal‐to‐noise ratio throughout the vision system.

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Relationship of Lutein and Zeaxanthin Levels to Neurocognitive Functioning: An fMRI Study of Older Adults

Cited by 45 publications

References 82 publications

Macular Xanthophylls and Event‐Related Brain Potentials among Overweight Adults and Those with Obesity

Macular Xanthophylls and Event‐Related Brain Potentials among Overweight Adults and Those with Obesity

Nutritional Gaps and Supplementation in the First 1000 Days

Dietary Carotenoids Lutein and Zeaxanthin Change Brain Activation in Older Adult Participants: A Randomized, Double‐Masked, Placebo‐Controlled Trial

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