Relationship of Maternal Folic Acid and Vitamin B12 with birth weight and body proportion of newborn

Ahmed, Abu Saleh; Akhter, Mahbooba; Sharmin, Shafia; Ara, Shamim; Hoque, Mozammel

doi:10.3329/jdnmch.v18i1.12224

Cited by 7 publications

(13 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand Guerra-Shinohara et al [4] found no correlation was detected between birth weight and maternal or neonatal biochemical variables (B12, RBC and serum folate and total homocysteine). In our study we revealed a strong significant positive correlation between maternal antenatal serum vitamin B12 and birth weight which is supported by Ahmed et al, and Frery et al [12] [49]. On the contrary, we also observed a strong negative correlation between maternal serum homocysteine and birth weight, and no correlation found between maternal serum folate and birth weight.…”

Section: Discussionsupporting

confidence: 68%

“…Moreover, maternal serum folic acid level showed insignificant differences between group A and B (9.57 ± 3.63 vs. 9.1 ± 2.73 respectively, P = 0.27), which contradicts other previous studies as [12] [36] [43]. A systematic review done by Fekete et al [44] showed two-fold increase in folate intake in early pregnancy is associated with 2% increase in birth weight, which is a slight but significant increase.…”

Section: Discussioncontrasting

confidence: 55%

“…Low vitamin B12 and folate in pregnant women have an impact on fetal birth weight by influencing placental development [9]. Previous studies explored that there is risk for low birth weight (LBW) infants born to vitamin B12 and folic acid deficient mothers [10] [11] [12].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Impact of Third Trimester Maternal Serum Vitamin B12 and Folate Status on Fetal Birth Weight. Is Maternal Serum Homocysteine a Predictor of Low Birth Weight Infants?

Youssry¹,

Radwan²,

Gebreel³

et al. 2017

OJOG

View full text Add to dashboard Cite

Objective: The aim of this study is to evaluate vitamin B12, folate, and homocysteine status in pregnant women in the third trimester of pregnancy and their relationship to fetal birth weight and their correlation to corresponding neonatal cord blood levels, and in addition, to evaluate the possibility of maternal serum homocysteine level as a predictor of low birth weight infants. Subjects and Methods: In this cross-sectional study, a total of two hundred pregnant women in third trimester (≥28 weeks) were recruited. After a detailed obstetrical and medical history, and clinical assessment, participants were subdivided into two groups: Group (A)-pregnant women who delivered average birth weight (ABW) infants and Group (B) for those who delivered low birth weight (LBW) infants between completed 37 and 42 weeks. Results: Vitamin B12 deficiency was observed in 24.1% of the total cohort. The mean vitamin B12 level was significantly lower in group (B) compared to group (A) (195.2 ± 38.9 vs. 225.9 ± 66.59 respectively P = 0.008). The mean level of homocysteine for women in group (B) was significantly higher than those determined from women in group (A) (9.10 ± 5.9 vs. 7.6 ± 3.83 respectively, P = 0.042). On the other hand, the mean folate levels showed statistically insignificant differences between both groups. The mean cord vitamin B12 level was significantly lower in LBW infants in comparison to ABW infants (277 ± 61.93 vs. 312.03 ± 81.87 respectively, P = 0.015), while the mean level of cord homocysteine for LBW infants was significantly higher than those levels determined from ABW infants (7.9 ± 3.79 vs. 6.6 ± 2.09 respec- deficiency could be significant risk for LBW infants. Hyperhomocysteinemia has been shown to be a predictor for adverse pregnancy outcomes particularly LBW.

show abstract

Section: Discussionsupporting

confidence: 68%

Section: Discussioncontrasting

confidence: 55%

See 1 more Smart Citation

The Impact of Third Trimester Maternal Serum Vitamin B12 and Folate Status on Fetal Birth Weight. Is Maternal Serum Homocysteine a Predictor of Low Birth Weight Infants?

Youssry¹,

Radwan²,

Gebreel³

et al. 2017

OJOG

View full text Add to dashboard Cite

show abstract

“…This result is in accordance with epigenetic dysregulation triggered by environmental cues during these sensitive periods of individual development can persist across the life course leading to altered disease susceptibility and even phenotypic changes. 8 The results of this study support the study of Ahmed et al, 2011 Glucose levels in the group that were treated with iron-folate supplementation were lower compared to control group. this results according to the Pravenec studies in SHR (spontaneously hypertensive rat) which showed that folate deficiency can promote oxidative stress and multiple features of the metabolic syndrome that are associated with increased risk for diabetes and cardiovascular disease.…”

Section: Discussionsupporting

confidence: 84%

Iron-Folate Supplementation during Pregnancy for Prevent Oxidative Stress in Pregnant Rats: Level of MDA, Creatinine, Glucose, Erythrocite, Blood Pressure, Body Weight and Number of Offspring

Wahyuwibowo¹,

Aziz²,

Safitri³

et al. 2020

View full text Add to dashboard Cite

Background: Iron and folic acid deficiency during pregnancy can increase oxidative stress and result in impaired intra-uterine growth, abortion and preeclampsia. Folate is trace nutrient that influent for essential role for epigenetic mechanism cues into changes in gene expression and had impact health development. This study aimed to determine the effect of several doses of iron and folate supplementation on level of: MDA, glucose, creatinine, maternal body weight and number and birth weight of offspring. Methods: This research was conducted in the laboratory of the Center for Food and Nutrition Studies, Gadjah Mada University Yogyakarta. Experimental research with posttest only control group design with a number of samples: 20 pregnant rats, divided randomly into 4 groups. The control group (C) was given standard feed (AIN-93G), KI: added iron 1,8 mg/200gBW and folic acid 0,0023mg/200gBW, KII: added iron 3,6 mg/200gBB and folic acid 0,0045 mg/200gBW, KIII : added iron 5,4mg/200gBW and folic acid 0,0068 mg/200gBW. Duration of treatment 20 days. Measurement of body weight, blood pressure and then taken blood samples at the 21 st day for examination of MDA, glucose, creatinine, erythrocyte level. Sectio caesarean to performed the number and body weight of offspring. Data obtained were analyzed using one way Anova followed by Post hoc LSD. Results: there are significant different (p <0.001). on level of : MDA, glucose, creatinine, maternal body weight, average number and fetal weight of offspring between treatment group compare to control group. Conclusion : Iron and folate suplementation during pregnancy can decreased level of oxidative stress and better pregnant outcome.

show abstract

“…Although the relationship between vitamin B 12 levels and birth weight is controversial, present study revealed significant association of first and second trimesters vitamin B 12 deficiency with LBW. Vitamin B 12 deficiency has been associated with LBW and intrauterine growth restriction (Rogne et al, ; Youssry, Radwan, Gebreel, & Patel, ; Ahmed, Akhter, Sharmin, Ara, & Hoque, ); however, a few studies did not find any association (Oztürk, Keskin, Tas, Akgün, & Avflar, ; Abraham, Mathews, Sebastian, Chacko, & Sam, . There is a need to improve the vitamin B 12 status among pregnant women as impaired status of maternal vitamin B 12 throughout pregnancy is a predictor for a high‐risk vitamin B 12 deficiency in infants (Finkelstein et al, ).…”

Section: Discussionmentioning

confidence: 99%

Trends of folate, vitamin B₁₂, and homocysteine levels in different trimesters of pregnancy and pregnancy outcomes

Mishra

Tomar

Puri

et al. 2020

American J Hum Biol

View full text Add to dashboard Cite

Objective: To evaluate the effect of folate and vitamin B 12 levels on pregnancy progression and outcomes. Methods: The present study is a prospective follow up study of 100 pregnant women. Biochemical investigations (plasma homocysteine, folate, and vitamin B 12 levels) were performed on all pregnant women in first, second, and third trimesters. Nonparametric tests were used to compare the differences in median levels and odds ratio analysis for the assessment of the risk between the selected biomarkers and adverse pregnancy progression and outcomes. Results: The pregnant women at their first antenatal care visit were found to be predominantly folate replete (97%) and vitamin B 12 deficient (60%). Hyperhomocysteinemia in first and second trimesters was found to pose more than 3-fold increased risk for adverse pregnancy outcomes (P = .006 and .0002, respectively). Low birth weight (LBW) was found to be the most common adverse pregnancy outcome (52%), and was significantly associated with vitamin B 12 deficiency in the first and second trimesters (82%, P < .0001; 71.4%, P = .04, respectively). Conclusion: The vitamin B 12 deficiency is more common among Indian pregnant women as compared to folate deficiency. Hyperhomocysteinemia is an independent risk factor for pregnancy complications. Vitamin B 12 deficiency in first and second trimesters is associated with LBW babies.

show abstract

Relationship of Maternal Folic Acid and Vitamin B12 with birth weight and body proportion of newborn

Cited by 7 publications

References 21 publications

The Impact of Third Trimester Maternal Serum Vitamin B12 and Folate Status on Fetal Birth Weight. Is Maternal Serum Homocysteine a Predictor of Low Birth Weight Infants?

The Impact of Third Trimester Maternal Serum Vitamin B12 and Folate Status on Fetal Birth Weight. Is Maternal Serum Homocysteine a Predictor of Low Birth Weight Infants?

Iron-Folate Supplementation during Pregnancy for Prevent Oxidative Stress in Pregnant Rats: Level of MDA, Creatinine, Glucose, Erythrocite, Blood Pressure, Body Weight and Number of Offspring

Trends of folate, vitamin B₁₂, and homocysteine levels in different trimesters of pregnancy and pregnancy outcomes

Contact Info

Product

Resources

About

Relationship of Maternal Folic Acid and Vitamin B12 with birth weight and body proportion of newborn

Cited by 7 publications

References 21 publications

The Impact of Third Trimester Maternal Serum Vitamin B12 and Folate Status on Fetal Birth Weight. Is Maternal Serum Homocysteine a Predictor of Low Birth Weight Infants?

The Impact of Third Trimester Maternal Serum Vitamin B12 and Folate Status on Fetal Birth Weight. Is Maternal Serum Homocysteine a Predictor of Low Birth Weight Infants?

Iron-Folate Supplementation during Pregnancy for Prevent Oxidative Stress in Pregnant Rats: Level of MDA, Creatinine, Glucose, Erythrocite, Blood Pressure, Body Weight and Number of Offspring

Trends of folate, vitamin B12, and homocysteine levels in different trimesters of pregnancy and pregnancy outcomes

Contact Info

Product

Resources

About

Trends of folate, vitamin B₁₂, and homocysteine levels in different trimesters of pregnancy and pregnancy outcomes