Relationship of metabolic syndrome and its components with thyroid dysfunction in Algerian patients

Hamlaoui, Mohamed Larbi; Ayachi, Ammar; Dekaken, Aoulia; Gouri, Adel

doi:10.1016/j.dsx.2017.08.001

Cited by 11 publications

(11 citation statements)

References 27 publications

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“…In line with our results, Kung et al. also found that the levels of TC, LDL-C, and HDL-C in patients with hyperthyroidism were significantly lower than control group ( 14 ); Hamlaoui and other studies also reached a similar conclusion ( 3 , 15 ). Our study analyzed the specific extent of the effect of hyperthyroidism on blood lipids by the regression model, and the results excluded the effect of other confounding factors, which are more convincing.…”

Section: Discussionsupporting

confidence: 92%

Menopausal Impact on the Association Between Thyroid Dysfunction and Lipid Profiles: A Cross-Sectional Study

et al. 2022

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BackgroundBoth dyslipidemia and thyroid dysfunction have a high prevalence rate and are important risk factors for cardiovascular diseases. However, the relationship between blood lipids and thyroid dysfunction is still controversial. This study aims to analyze the blood lipids in people with different thyroid functions.MethodsA total of 80937 adults were included in this population-based cross-sectional TIDE survey, which collected demographic and clinical data on thyroid function, blood lipid levels and other metabolic indicators. After screening, the final analysis included 10,747 participants, who were divided into hypothyroidism (n=311), subclinical hypothyroidism (n=5015), hyperthyroidism (n=203), subclinical hyperthyroidism (n=118) and control (n=5100) groups. The risk of dyslipidemia was analyzed by a logistic regression model and divided into groups of female menopausal.ResultsAfter full adjustment, significant associations were found between hypothyroidism and hypertriglyceridemia. Subclinical hypothyroidism was associated with a significantly higher risk of hypertriglyceridemia and hyper-low density lipoprotein cholesterolemia. Hyperthyroidism was significantly correlated with a reduced risk of hypercholesterolemia and hyper-low density lipoprotein cholesterolemia but positively correlated with the risk of low-high density lipoprotein cholesterolemia. There was no significant association between subclinical hyperthyroidism and blood lipids. Hypothyroidism increased the risk of hypertriglyceridemia in both premenopausal and postmenopausal females. Subclinical hypothyroidism was significantly associated with increased hypertriglyceridemia and low-high density lipoprotein cholesterolemia in premenopausal females. Hyperthyroidism was significantly associated with a reduced risk of hypercholesterolemia and hyper-low density lipoprotein cholesterolemia in premenopausal females and an increased risk of low-high density lipoprotein cholesterolemia in postmenopausal female.ConclusionAbnormal thyroid function has an important effect on blood lipids and is closely related to female menopause.

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Section: Discussionsupporting

confidence: 92%

Menopausal Impact on the Association Between Thyroid Dysfunction and Lipid Profiles: A Cross-Sectional Study

et al. 2022

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“…[3][4][5] Thyroid dysfunction can lead to obesity or obesity-related diseases, such as metabolic syndrome, hypertension, hyperglycemia, and dyslipidemia. [6][7][8] Modest alterations in thyroid hormone levels are common among obese people. 9,10 Associations between thyroid hormones and related components of obesity have been reported in recent studies.…”

Section: Introductionmentioning

confidence: 99%

Effects of thyroid hormone and depression on common components of central obesity

Kuang

Duan

et al. 2019

J Int Med Res

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Objective We investigated the prevalence of abnormal thyroid function and depression in centrally obese participants, and to analyze the relationship of thyroid hormones and depression with components of central obesity. Methods We randomly selected 858 centrally obese participants and 500 non-obese controls in this study. For all participants, we measured serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), body mass index (BMI), waist–hip ratio (WHR), fasting blood glucose and insulin, homeostasis model assessment of insulin resistance (HOMA-IR), lipid concentrations, and blood pressure. Depression was assessed using the Center for Epidemiological Studies-Depression (CES-D) scale. Results Centrally obese participants had a higher prevalence of hypothyroidism and depression than non-obese controls. Serum FT4 levels negatively correlated with BMI and serum TSH levels and positively correlated with BMI, WHR, total triglycerides (TG), total cholesterol (TC), and low density lipoprotein cholesterol (LDL-C). After excluding participants with hypothyroidism and hyperthyroidism, serum FT4 levels showed negative correlation and serum TSH levels showed positive correlation with BMI in the remaining centrally obese participants. CES-D scores positively correlated with BMI. Conclusion We found high prevalences of hypothyroidism and depression among centrally obese participants. FT4 and TSH are important in weight regulation. Depression positively correlated with obesity.

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“…42 Similarly, a study of the relationship of metabolic syndrome and its components with thyroid dysfunction in Algerian patients found that high TSH was associated with a higher incidence of metabolic syndrome, and that TSH concentration positively correlated with the prevalence of metabolic syndrome. 43 Furthermore, a study of 949 euthyroid postmenopausal women found that the prevalence of metabolic syndrome in women in the highest TSH concentration quintile was about 1.95 times higher than that for women in the lowest quintile. 44 A Korean study also showed a significant increase in the prevalence of metabolic syndrome alongside an increase in TSH concentration.…”

Section: Relationships Between the Prevalence Of Metabolic Syndrome Amentioning

confidence: 99%

Epidemiology of metabolic syndrome and its components in Chinese patients with a range of thyroid-stimulating hormone concentrations

et al. 2020

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Objective To investigate the relationship between thyroid stimulating hormone (TSH) concentration and the risks of developing metabolic syndrome and its components. Methods A total of 10,140 residents of the Yunyan district of Guiyang (Guizhou, China) who were ≥40 years old were selected by cluster random sampling between May and August 2011, of whom 5692 were eligible. TSH concentration and indices of metabolic syndrome were documented at baseline and 3 years later. Participants were allocated to a euthyroid (TSH 0.55–4.78 mIU/L) or high TSH concentration (TSH >4.78 mIU/L) group. Patients with overt hypothyroidism or were undergoing treatment for hypothyroidism were excluded. Results The crude and adjusted prevalences of metabolic syndrome were 39.9% and 33.9% in the euthyroid group and 44.3% and 37.5% in the high TSH group, respectively. Binary logistic regression analysis revealed a positive correlation between a high TSH concentration at baseline and the cumulative incidence of metabolic syndrome during follow up. Conclusions High TSH is associated with a higher risk of developing metabolic syndrome or one of its components; therefore, people with a high TSH concentration should be screened regularly to permit the early identification of metabolic syndrome and followed up thoroughly.

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Relationship of metabolic syndrome and its components with thyroid dysfunction in Algerian patients

Cited by 11 publications

References 27 publications

Menopausal Impact on the Association Between Thyroid Dysfunction and Lipid Profiles: A Cross-Sectional Study

Menopausal Impact on the Association Between Thyroid Dysfunction and Lipid Profiles: A Cross-Sectional Study

Effects of thyroid hormone and depression on common components of central obesity

Epidemiology of metabolic syndrome and its components in Chinese patients with a range of thyroid-stimulating hormone concentrations

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