Relationship of Milan Antigen to Abnormal Serum Lipoprotein

History of the Discovery of Hepatitis A Virus

“…Characterization of the antigen revealed it to have a density of only 1.06 gm/cm 3 and electron microscopy (EM) studies revealed disk-like structures of varying size up to 50 nm, suggesting that Milan antigen was likely an abnormal serum lipoprotein often associated with liver disease (Fig. 1) (Taylor et al 1972).…”

“…Figure 1. Milan antigen showing disc-like structures associated with serum lipoproteins(Taylor et al 1972).…”

Viral infections of the liver in childhood

“…The Milan antigen (also referred to in the past as Epidemic-Hepatitis-Associated-Antigen), detected by gel diffusion in the serum of a large proportion of patients during the acute phase of hepatitis A (Del Prete et al, 1970), has since been shown to be a serum lipoprotein, possibly abnormal and lacking specificity for type A hepatitis (Taylor et al, 1972). In other studies, Ferris et al (1970) reported the presence of an antigen in extracts of faeces obtained from about 50% of patients admitted to hospital during the first 3 weeks of hepatitis A infection.…”

Ερευναι Επι Του Αυστραλιανου (Au) Αντιγονου Εις Τα Ουρα Τα Κοπρανα Και Την Χολην

“…"Οσον άφορφ είς το υπό του Del Prete άνακαλυφθέν άντιγόνον Ε. Η.Α.Α., δέν υπάρχουν αδιάψευστοι αποδείξεις οτι όντως τοΰτο σχετίζεται μέ τον ϊόν Α 185 , καίτοι κατ' άλλους έρευνητάς υπάρχουν αρκετά συνηγό ρου ντα στοιχεία 67 .…”