Relationship of mitochondrial energy production with the rate and efficiency of whole body growth in young growing animals

Abstract

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Mitochondrial performance of a continually growing marine bivalve, Mytilus edulis Linnaeus, depends on the body size

“…The link between mitochondrial functioning and growth performance has been reported in several endotherms and ectotherms species. Thus, the rate of mitochondrial energy production in muscle influenced the rate of body growth in pigs from the same genetic strain and in rats (Lutz, 2003). Lower rates of OXPHOS respiration and lower mitochondrial RCR were associated with reduced daily body mass gain in pigs growing from 18 to 28 kg.…”

“…Lower rates of OXPHOS respiration and lower mitochondrial RCR were associated with reduced daily body mass gain in pigs growing from 18 to 28 kg. Furthermore, declines in proton leak-dependent respiration in pigs growing from 8 to 18 kg were associated with improvements in the efficiency of feed utilization (Lutz, 2003). The enhanced mitochondrial performance (and improved growth rates) was associated with higher levels of protein expression of the adenine nucleotide translocase type 1 (ANT1) in the muscles of pigs (Lutz, 2003), suggesting a role of the improved ATP and ADP transport in mitochondrial performance.…”

“…Furthermore, declines in proton leak-dependent respiration in pigs growing from 8 to 18 kg were associated with improvements in the efficiency of feed utilization (Lutz, 2003). The enhanced mitochondrial performance (and improved growth rates) was associated with higher levels of protein expression of the adenine nucleotide translocase type 1 (ANT1) in the muscles of pigs (Lutz, 2003), suggesting a role of the improved ATP and ADP transport in mitochondrial performance. Lower rates of mitochondrial proton leak and elevated RCR in muscle mitochondria were also associated with improved body mass gain to feed ratios in growing rats (Lutz, 2003).…”

“…The enhanced mitochondrial performance (and improved growth rates) was associated with higher levels of protein expression of the adenine nucleotide translocase type 1 (ANT1) in the muscles of pigs (Lutz, 2003), suggesting a role of the improved ATP and ADP transport in mitochondrial performance. Lower rates of mitochondrial proton leak and elevated RCR in muscle mitochondria were also associated with improved body mass gain to feed ratios in growing rats (Lutz, 2003). A study on poultry (broilers) and cattle (steers) showed that growth-efficient animals (with higher mass gain to feed intake ratios) had higher mitochondrial coupling (RCR) than growth-inefficient ones, while oxidative phosphorylation efficiency assessed by the ADP:O ratio did not differ between growth-efficient and -inefficient groups (Bottje and Carstens, 2009).…”

“…Recent research showed a functional link between intraspecific variation in mitochondrial performance and individual growth rates in several species of vertebrates including endotherms such as rats, pigs (Lutz, 2003), chickens and cows (Bottje and Carstens, 2009), and ectotherms such as frogs (Salin et al, 2012a,b). Cross-species comparisons in 12 species of mammals showed that mitochondrial efficiency (measured as ATP:O ratio) was positively correlated with body mass when mitochondria were functioning at close to the basal metabolic rate; however, the efficiency was independent of body mass in mitochondria respiring at the maximum OXPHOS rate (Mélanie et al, 2019).…”