Relationship of Molecular Size of rIn:rCn (Poly I:C) to Induction of Interferon and Host Resistance

Studies on the Toxicity and Antiviral Activity of Various Polynucleotides

“…It is of interest that this nearly constant antiviral activity in tissue culture held at concentrations of inducer (10-5. ug/ml) which were 100-fold lower than those reported in previous studies (10,18). In rabbits and in mice, there was a fairly similar dependence of interferon production upon homopolymer pair size.…”

“…The in vivo interferon production assay is undoubtedly more accurate. (10,13,18). This fact suggests that the structure of their preparations of (poly rI) -(poly rC) differed from that of typical preparations of this compound.…”

“…The effect of molecular weight on the ability of (poly rI) * (poly rC) to produce interferon in vivo and antiviral resistance in tissue culture and in vivo has been studied (10,18). Another study has compared the influence of the molecular weight of this compound on its ability to produce antiviral resistance in tissue culture and to cause toxicity in mice (15).…”

Influence of Molecular Weights of Bacteriophage φ6 Double-Stranded Ribonucleic Acids on Interferon Induction

“…of' Leuven, Belgium. 1971), and Lampson et al (8) in studies with associated synthetic homopolymers poly rI and poly rC. A correlation of' higher antiviral activity to higher molecular weight of' the double-stranded complex was generally observed in their studies.…”

The Effect of Altering the Size of Poly C on the Toxicity and Antigenicity of Poly I:C

“…Previous studies from these laboratories (1,2) recorded that the interferon and resistance-inducing capacities of poly I : C (rIn : rCn) were markedly affected by the size of poly I : C and of its component homopolymers. The present report is an extension of these studies and shows that acute toxicity for mice and antigenicity for rabbits of poly I:C can be markedly reduced by altering the size of the poly C component of the complex without affecting induced antiviral activity.…”