1984
DOI: 10.1002/jps.2600731047
|View full text |Cite
|
Sign up to set email alerts
|

Relationship of Morphine-Induced Miosis to Plasma Concentration in Normal Subjects

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

0
6
0

Year Published

1988
1988
2022
2022

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 13 publications
(6 citation statements)
references
References 11 publications
0
6
0
Order By: Relevance
“…Indeed opioids induce dose-dependent miosis. 13 The exact site within the central nervous system responsible for opioid-induced miosis is unknown, but seems to be dependent on the parasympathetic nervous system in animals. 14 Under desflurane, sevoflurane, isoflurane or propofol, opioids do not significantly decrease pupil size, as the pupil is already maximally constricted.…”
Section: Discussionmentioning
confidence: 99%
“…Indeed opioids induce dose-dependent miosis. 13 The exact site within the central nervous system responsible for opioid-induced miosis is unknown, but seems to be dependent on the parasympathetic nervous system in animals. 14 Under desflurane, sevoflurane, isoflurane or propofol, opioids do not significantly decrease pupil size, as the pupil is already maximally constricted.…”
Section: Discussionmentioning
confidence: 99%
“…One possibility for the differences is that perhaps oral oxycodone has a different psychopharmacological profile than oral morphine. However, only one dose of morphine was tested; furthermore, the 30 mg oxycodone dose (and the 20 mg dose) produced a statistically significantly greater degree of miosis than 40 mg morphine, indicating the dosages were not equipotent on a prototypic physiological response to opioids (e.g., Fedder et al 1984;Martin 1984;Benziger et al 1997). The comparison of 40 mg of morphine to 30 mg of oxycodone was based on a morphine/oxycodone analgesic potency ratio of 1.3:1 reported in a study on cancer-pain patients in severe pain (Kalso and Vainio 1990), but there are other reported analgesic potency ratios (e.g., Foley 1985; Curtis et al 1999).…”
Section: Introductionmentioning
confidence: 99%
“…Thus, because analgesic effects were uncertain to provide a basis to judge the contribution of codeine metabolites other than morphine to its effects and side effects such as sedation or headache often provide a weak data basis for exact quantification of opioid effects, we chose the pupil diameter as the target parameter for this study (for review, see reference 15). Pupil size has been found to be an acceptable surrogate for opioid effects 16 , 17 , 18 , 19 , 20 , 21 , 22 and had the advantage in the present context of an easily repeatable parameter to obtain frequent sensitive measurements of the opioid effect that could provide a suitable data basis for the presently used pharmacokinetic (PK)鈥損harmacodynamic (PD) modeling approach to the contribution of codeine metabolites to its effects.…”
mentioning
confidence: 99%