Relationship of Native Heparin to Clearing of an Alimentary Liepmia.

The effects of in vivo heparin on plasma esterase activity and lipaemia clearing*

“…The role of heparin in this lipaemia-clearing system is not clearly understood since its presence has been reported as being possibly non-essential for the clearing reaction (Levy & Swank, 1953). However, since the methods of heparin assay based on its anticoagulant or metachromatic properties may not detect amounts of blood heparin sufficient to cause clearing, such determinations of blood heparin activity are no absolute criterion for its requirement in the clearing reaction.…”

“…However, since the methods of heparin assay based on its anticoagulant or metachromatic properties may not detect amounts of blood heparin sufficient to cause clearing, such determinations of blood heparin activity are no absolute criterion for its requirement in the clearing reaction. It is known that lipaemic animals which have suffered circulatory shock due to anaphylaxis or to the injection of certain histamine liberators may release enormous amounts of heparin into the blood without evidence of clearing (Levy & Swank, 1953). It seems possible, therefore, that traces of heparin or some heparin substitute are needed for the clearing reaction, and that this reaction may be inhibited by other agents released during shock.…”

The esteratic and chylolytic properties of post‐heparin plasma and their role in lipaemia clearing*

“…Post-heparin plasma samples from different dogs were used in duplicate tests which yielded the same general results as those described in Fig. 10 (Levy & Swank, 1953), the effects of histamine dihydrochloride and the potent histamine-liberator diaminodecane dihydrochloride (DA 10) were studied. These substances in concentrations of 10-2 M caused 20 % inhibition of the esterase activity induced by heparin.…”

“…Several other agents have been examined for their possible influence on the esterase and clearing-factor activities of post-heparin plasma. In line with earlier work (Levy & Swank, 1953), the effects of histamine dihydrochloride and the potent histamine-liberator diaminodecane dihydrochloride (DA 10) were studied. These substances in concentrations of 10-2 M caused 20 % inhibition of the esterase activity induced by heparin.…”

Le Métabolisme Lipidique dans le Syndrome Néphrotique.

“…Ce phénomène ne se produit qu'/« vivo (Hahn, 1943 ;Weld, Swank, 1953). L'héparine modifie profondément le le spectre des lipoprotéines (Graham, Lyon, Gofman, Jones, Yankley, SiMONTON et Write, 1951).…”