1996
DOI: 10.1111/j.1445-5994.1996.tb02908.x
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Relationship of non‐specific airway hyper‐responsiveness (AHR) to measures of peak expiratory flow (PEF) variability

Abstract: These results suggest that while PEF variability may reflect AHR for the purposes of epidemiologic studies, it is unlikely to be useful as a simple 'non-invasive' means of assessing AHR in individual patients. More complex measures of PEF variability do not have an advantage over simpler measures such as mean morning PEF.

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Cited by 5 publications
(3 citation statements)
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“…Peak expiratory flow rate (PEFR) variability may reflect bronchial hyperresponsiveness by means of an independent technique [10]. The level of PEFR variability was low in the present material, which indicates that the asthmatics had a mild form of the disease and a low level of unspecific bronchial hyperresponsiveness.…”
Section: Discussionmentioning
confidence: 53%
See 1 more Smart Citation
“…Peak expiratory flow rate (PEFR) variability may reflect bronchial hyperresponsiveness by means of an independent technique [10]. The level of PEFR variability was low in the present material, which indicates that the asthmatics had a mild form of the disease and a low level of unspecific bronchial hyperresponsiveness.…”
Section: Discussionmentioning
confidence: 53%
“…PEFR variability was calculated from the maximal minus the minimal value divided by the mean for the period. The PEFR variability was used as an independent indicator of bronchial hyperresponsiveness [10]. The study was approved by the local Ethics Research Committee and informed consent was obtained from all subjects before being included in the study.…”
Section: Patientsmentioning
confidence: 99%
“…The clinical diagnosis of asthma is based on characteristic patterns of symptoms, and is supported by evidence of airway hyperresponsiveness, variable airflow limitation or response to treatment [4]. Airway hyperresponsiveness (AHR) is commonly assessed by bronchial provocation with methacholine or histamine [5], while variable airflow limitation is detected by observing spontaneous or treatment-related variability in forced expiratory volume in one second (FEV1) or in peak expiratory flow (PEF), expressed as amplitude per cent mean [6], low per cent best [7], or in other less common ways [8]. However, these objective measures do not always correlate strongly with each other [6] and may-measure different pathophysiological aspects of the disease [7±9].…”
mentioning
confidence: 99%