Relationship of Normal Serum Vitamin B12 and Folate Levels to Cognitive Test Performance in Subtypes of Geriatric Major Depression

Bell, Iris R.; Edman, Joel S.; Miller, Joshua W.; Hebben, Nancy; Linn, Richard T.; Ray, Diane C.; Kayne, Herbert L.

doi:10.1177/089198879000300208

Cited by 32 publications

(10 citation statements)

References 37 publications

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“…The median years of education was 15 (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Twenty-five (75.8%) patients were lacto-vegetarian, seven (21.2%) were infrequent nonvegetarian (less than two times per month), and only one (3.0%) consumed non-vegetarian food more than two times per month.…”

Section: Subjects' Characteristicsmentioning

confidence: 99%

“…Improvement following vitamin B12 therapy has been demonstrated in the patients presenting with cognitive or behavioral abnormalities in comparison with the controls on verbal fluency test, but other investigators have failed to confirm these optimistic results. 10,11 Some authors feel that vitamin B12 treatment may improve frontal lobe and language functions in patients with cognitive impairment but rarely reverses dementia. 12 P3 has been used to document cognitive dysfunction especially to monitor the effect of therapy in Alzheimer's disease, HIV-associated dementia, and encephalitis.…”

Section: Introductionmentioning

confidence: 99%

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A study of neurobehavioral, clinical psychometric, and P3 changes in vitamin B12 deficiency neurological syndrome

Kalita

Agarwal

Chandra

2013

Nutritional Neuroscience

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Section: Subjects' Characteristicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A study of neurobehavioral, clinical psychometric, and P3 changes in vitamin B12 deficiency neurological syndrome

Kalita

Agarwal

Chandra

2013

Nutritional Neuroscience

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“…Although there are a number of published studies which have suggested links with vitamin status and cognitive performance amongst the elderly (for example, see Goodwin et al 1983;Sommer & Wolkowitz, 1988;Bell et al 1990;Riggs et al 1996), these studies have been correlational in nature and have provided no clear hypothesis as to the mechanisms underlying these relationships. One intervention study, however, revealed no effect of supplementation on cognitive performance (Chome et al 1986), although this can possibly be interpreted in terms of the low subject numbers and the relatively short period of supplementation (5 weeks).…”

Section: B-complex Vitamins Folate and Neural Functionmentioning

confidence: 99%

Nutritional influences on cognitive function: mechanisms of susceptibility

Gibson

Green

2002

NRR

121

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The impact of nutritional variation, within populations not overtly malnourished, on cognitive function and arousal is considered. The emphasis is on susceptibility to acute effects of meals and glucose loads, and chronic effects of dieting, on mental performance, and effects of cholesterol and vitamin levels on cognitive impairment. New developments in understanding dietary influences on neurohormonal systems, and their implications for cognition and affect, allow reinterpretation of both earlier and recent findings. Evidence for a detrimental effect of omitting a meal on cognitive performance remains equivocal: from the outset, idiosyncrasy has prevailed. Yet, for young and nutritionally vulnerable children, breakfast is more likely to benefit than hinder performance. For nutrient composition, despite inconsistencies, some cautious predictions can be made. Acutely, carbohydrate-rich-protein-poor meals can be sedating and anxiolytic; by comparison, protein-rich meals may be arousing, improving reaction time but also increasing unfocused vigilance. Fat-rich meals can lead to a decline in alertness, especially where they differ from habitual fat intake. These acute effects may vary with time of day and nutritional status. Chronically, protein-rich diets have been associated with decreased positive and increased negative affect relative to carbohydrate-rich diets. Probable mechanisms include diet-induced changes in monoamine, especially serotoninergic neurotransmitter activity, and functioning of the hypothalamic pituitary adrenal axis. Effects are interpreted in the context of individual traits and susceptibility to challenging, even stressful, tests of performance. Preoccupation with dieting may impair cognition by interfering with working memory capacity, independently of nutritional status. The change in cognitive performance after administration of glucose, and other foods, may depend on the level of sympathetic activation, glucocorticoid secretion, and pancreatic ␤-cell function, rather than simple fuelling

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“…Bell et af. [21] reported an association between low or low-normal concentration of serum cobalamin and blood folate and certain neuropsychiatric disorders in elderly subjects, particularly depression. Therefore in this study we determined plasma homocysteine and its main determinants [22], serum cobalamins, blood folate, and serum creatinine in 741 psychogeriatric patients and compared the findings with those in a reference population (n = 163).…”

Section: Introductionmentioning

confidence: 99%

Hyperhomocysteinaemia—a common finding in a psychogeriatric population

Nilsson¹,

Gustafson²,

Fäldt

et al. 1996

Eur J Clin Investigation

137

122

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Plasma homocysteine concentration is a sensitive marker for cobalamin and folate deficiency. The previously reported high incidence of increased plasma homocysteine in psychogeriatric patients and the association between reduced concentrations of cobalamin, folate and neuropsychiatric symptoms led to the present study on 741 consecutive psychogeriatric patients. The concentrations of plasma homocysteine correlated significantly with blood folate, serum cobalamin and serum creatinine both in demented (n = 295) and in non-demented patients with other psychiatric disorders (n = 215). Plasma homocysteine concentrations were significantly increased in both the demented and the non-demented patients, whereas only the demented patients had lower blood folate and serum creatinine concentrations than 163 control subjects. Almost all of the different diagnostic groups of demented and non-demented patients exhibited significantly increased plasma homocysteine concentrations compared with control subjects. Significantly decreased blood folate concentrations were mainly found in the different diagnosis groups of demented patients. Plasma homocysteine concentrations in both demented and non-demented patients with serum cobalamin and blood folate above the lower 20th percentile of these vitamins in the control subjects were also studied. Despite these vitamin concentrations, both groups of patients still exhibited significantly higher plasma homocysteine concentrations than the control subjects, which may indicate an increased frequency of impaired genetic capacity to metabolize homocysteine in these patients. Patients with either dementia of vascular cause or a history of other occlusive arterial disease had a significantly higher plasma homocysteine concentration than those without a history of vascular disease.

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Relationship of Normal Serum Vitamin B12 and Folate Levels to Cognitive Test Performance in Subtypes of Geriatric Major Depression

Cited by 32 publications

References 37 publications

A study of neurobehavioral, clinical psychometric, and P3 changes in vitamin B12 deficiency neurological syndrome

A study of neurobehavioral, clinical psychometric, and P3 changes in vitamin B12 deficiency neurological syndrome

Nutritional influences on cognitive function: mechanisms of susceptibility

Hyperhomocysteinaemia—a common finding in a psychogeriatric population

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